Faculty Details

Faculty Details

  • Name: Prof. N. Siva Kumar
  • Mail: nsksluohyd.ernet.in
  • Contact: 91-40-23134569
  • Area Of Research:Glycobiology, Cell and Molecular Biology, Nanobiotechnology

Academic appointments

Senior Professor, Department of Biochemistry (February 2019)

Professor, University of Bremen, Germany (DAAD Visiting Professor March to July 2019)

Professor, Department of Biochemistry (November 2004)

Reader, (Associate Professor) Department of Biochemistry (August 1998)

Senior Lecturer, School of Life Sciences (September 1991)

Lecturer, (Assistant Professor) School of Life Sciences (September 1986)


Administrative appointments

Director, Office of International Affairs (2018-2021- 3 years)

Coordinator MHRD SPARC Program, University of Hyderabad (2019-2021)

Coordinator NPTI Program  UoH and U of Goettingen Germany (2019-2023)

Coordinator MHRD, Study in India, (2018 onwards)

Member of the LPPMC (Local Programme Planning and Management) committee of HRDC,

UoH – February 2020 for 2 years.

Member of the Purchase Committee, School of Life Sciences as Senior Most Professor

Coordinator of the DAAD, New Passage to India (2019-2023) University of Goettingen

Coordinator University of Muenster MoU (2017-2022)

Head Biochemistry Department (2014-2017- 3years)

In-charge Dean, School of Life Sciences(Several Weeks,~4-5 months: during 2014-17, to date)

Coordinator of the GIAN Course – Glycoconjugates: Role in Biology and Biomedical Relevance November 2017 Prof. Dr. Dr. h.c. Kurt von Figura, Goettingen, Germany

Coordinator of the UGC-SAP-DRS-1, Department of Biochemistry (2016-2021-5 years)

Coordinator of the DST-FIST Program, Department of Biochemistry (2014-2017)

Coordinator –School level) Centre for Nanotechnology (2010-2017)

Steering Committee Member (Asian Community of Glycoscience and Glycotechnology)

Steering Committee Member, TRendys in Biochemistry (Since 2016)

Coordinator of the NAMASTE (Networking & Mobility Actions for Sustainable Technology Program) of the EU, being coordinated by the University of Goettingen (2013-2017) Project Coordinator of the First International Research Training Group in Molecular and Cellular Glycosciences, (UGC-India and DFG-Germany) 2009-2017.


Board Memberships

Member of the College for Integrated Studies School Board (3 years)

Member of the School Board of Life Sciences (Since 2004)

Member of the Academic Council, University of Hyderabad (since, 2004)

Member of the School Board of Engineering Science and Technology School (2017-2020)

Member of the Department Council (CASEST, School of Physics, 2018-2020)

Member JNU-CCMB Academic Committee (2016-2018-2 years)

Member of the School Board, School of Life Sciences, Pondicherry Central University (2016-2019)

Member, Board of Studies, Biotechnology Department, GITAM University, Visakhapatnam (2018-2021).

Member of the Academic Committee – Bhavan’s Post Graduate College of Science, Secunderabad (2018-2020) 2 years

 

DBT Nominee … Vivimed Labs, Hyderabad,  3 years

DBT - IBSC Nominee …  Yapan Bio Private Limited, Hyderabad


Professional Societies

Life member, Society of Biological Chemists, India

Chair, 6th Asian Community of Glycoscience and Glycotechnology, 2014 December, University of Hyderabad, India)

Steering Committee Member - Asian Community of Glycoscience and Glycotechnology

Convener, TRendys in Biochemistry, India (2016 onwards along with Prof. Anand K. Kondapi)

 

Awards / Fellowships / Honours [including Ph.D. students]

International 

7. DAAD Visiting Professorship by invitation to teach for one semester in an international Program Masters in Biochemistry and Molecular Biology (March to July 2019) in University of Bremen, Germany

6. Three Ph.D. students DAAD-Fellowships (2-Sandwich model -worked in Goettingen, Greifswald,1 short term-Greifswald)

5. Two Ph.D. students best poster awards in International Meetings

4. Recipient of an International Research Grant supported by the Volkswagen research Foundation, Germany (2000-2006 I/78096., I/78193). Only Principal investigator from India Prof. N. Siva Kumar: German collaborators: Prof. Dr. Dr. h. c. K. von Figura,  Goettingen University, Prof. Dr. Regina Pohlmann, University of Muenster, Germany. Total amount (2000-2005) about Rs. 58 lakhs (Completed). (These projects are highly competitive in nature internationally and only the best would get the funding)

3. Visiting Scientist fellowship by Prof. Dr. K. von Figura, University of Goettingen, Goettingen, Germany,  (1995, 1996 and 1997 Summertime 2, 3 months and 2 weeks)

2. The German Academic Exchange Service Fellowship, Reinvitation program, (May-July 1994) European Molecular Biology Laboratories, Heidelberg. Prof. Dr. B. Hoflack

1. The German Academic Exchange Service Fellowship through UGC, Government of India, worked in the laboratories of Prof. Dr. H. Ruediger, (1988 September to May 1989), University of Wuerzburg, Institut fur Pharmazie Und Lebensmettel Chemie, Am Hubland, Wuerzburg, 97074, Germany, and Prof. Dr. K. von Figura, (June 1989-June 1990) Institut fur Biochemie Und Molekulare Zellbiologie, Georg-August Universitaet, Gosslerstrasse 12D, Goettingen, 37073, Germany

 

 

National

10. Kavyashree S.R. Award for Research Proficiency from the Biochemistry Department: Publication in International JOurnal of Biological Macromolecules (2019)

9.  Kavyashree S.R. Award for Research Proficiency from the Biochemistry Department: Publication in International Journal of Biological Macromolecules (2019)

8.   A. Ajith Kumar - Award for Research Proficiency from the Biochemistry Department: Takifugu rubripes cation independent Mannose 6-phosphate receptor : cloning expression and functional characterization of the IGF-II binding domain.  Published in International Journal of Biological Macromolecules: (2018) 


7. Dr. Mohammad Javed Ali (LVPEI, Hyderabad) has worked for his Ph.D. in Biochemistry under my guidance on a research topic, Glycobiology of The Lacrimal Drainage System and obtained his Ph.D. in 2018. He made significant contributions in eye research and was awarded the prestigious Shanti Swarup Bhatnagar Prize for Science and Technology in Medical Sciences for the year 2019.

6. UGC Mid Career Award – 2018

5. Awarded the Andhra Pradesh Scientist Award 2012 in Biological Sciences for the outstanding teaching and research contributions made in the field of Glycobiology

4. Awarded the DBT, Overseas associateship, 2008 to carry out research for 6 months

(March-September, 2009) in the University of Goettingen, Goettingen, Germany. Collaborator – Dr. Bernhard Schmidt.

3. Awarded the Prof. M. Sadhaksharaswamy Endowment Lecture Award 2007, by the Society for Biological Chemists (India) for outstanding contributions in teaching and research in the field of biological chemistry and allied sciences. 

2. Elected Fellow of the Andhra Pradesh Akademi of Sciences, India, March 2006

1. Recipient of Indian National Science Academy Visiting Fellowship (1995-1996) worked in the laboratory of Prof. N. Appaji Rao, at Biochemistry Department, Indian Institute of Science, Bangalore, India


Teaching and Research

Actively involved in teaching for Postgraduate students at the University of Hyderabad courses such as the Carbohydrate and Lipid Metabolism, Protein amino acid and Nucleotide Metabolism. Glycoconjugates: Role in Biology and Biomedical Relevance as an Elective course. Glycobiochemistry (University of Bremen). In addition to teaching courses, lab classes in the subjects concerned were also conducted.

Taken several classes as part of the HRDC Centre in UoH for teachers. Invited to GITAM College, Visakhapatnam to deliver lectures to their Master students in Biotechnology.

Research

Number of Projects completed: 14 (including one International supported by the Volkswagen Research Foundation, Germany 2000-2006).

Ongoing Projects :

1. UGC-BSR Mid-career Award - 10 Lakhs -  2 years (Start date - March 2019)

Quantitative proteomics of Protein Body components (lectins and glycosidases), from the Trichosanthes anguina seeds: elucidation of protein-protein interactions in the protein body biogenesis

2. DST-SERB

Biochemical investigation of endosomal targeting proteins and functional analysis of lysosomal enzymes and their receptors in Hydra - ~58 lakhs – 3 years Start date 4th June 2019).

Number of Ph.D.’s supervised: 20

(Individual students listed under Members)

Postdocs Mentored – 3 - Currently working – 3 (DST-NPDF and UGC Kothari-2019, DST-SERB-Research Associate)

Number of peer-reviewed Research publications – 90 (4 under submission, 2 under revision).

Number of invited talks and Conference presentations (India and Abroad) individual and by students from laboratory – > 75 (since 1986 to date)

Journals where research work is published

 

Google Scholar Citations – 933. Highest citations 54, J.Biol.Chem., H index: 17., i10 index-31

FEBS.LETT (3.5), J.Cell Biol (11.7), J. Biol. Chem (6.3), Comp. Biochem & Physiol(2.0), Development, Genes, and Evolution (2.2), Colloids, Surfaces, and Interfaces B (4.40), Glycoconjugate J (1.9), Glycobiology(3.74), Int. J. Biol. Macromolecules(5.162), Biochimie(3.2), Current Protein and Peptide Science (3.1), Biochim. Biophys. Acta (4.4), Bioscience Reports(2.6),J. Chromatography (3.7), J. Biochemical and Biophysical Meth(1.3), Organic Biomolecular Chem(3.5), Glycobiology (4), Protein Expression & Purification (1.5), Phytochemistry(1.9), Bioscience, Biotechnology, Biochemistry(1.06), Current Science(0.51), Biochemistry Molecular Biology International (0.8), Graefes Arch Clin Exp Ophthalmol (2.249),  Ophthal Plast Reconstr Surg (1.283), IJCMPR (1.6), Developmental Dynamics (3.25).

 

Published papers (90) in specialized areas as listed Nadimpalli Siva Kumar #-Corresponding author [80+]

Under submission [4] Details can be seen in the Publications list on this site.

 

The research publications are mostly in the area of Protein Biochemistry and Glycobiology. Several new methods were developed for the large scale purification of plant and animal lectins and glycosidases. Purified protein structure and functions were elucidated using various biochemical, cell biological, molecular biological, immunological, biophysical, and Mass spectrometric techniques. Crustal structure for a galactose specific lectin purified in our lab was also elucidated.

The lysosomal biogenesis pathway has been established by us to be conserved from fish to mammals, and current studies being focussed on invertebrates has provided new insights into the evolution of the lysosomal biogenesis pathways which involves inter-organellar communications (ER to Golgi - to Endosomes - to Lysosomes).

Nanotechnology-based research involving preparation, characterization of protein and oligosaccharide nanoparticles gave new insights into the usefulness of these as drug delivery systems.

More recent work involving the human lacrimal system and the glycoprotein profiling of the human lacrimal gland has given new inputs on this unexplored tissue and paved way to further expand and extend these studies towards understanding the specific roles of some glycoproteins in the lacrimal gland tissue.

Both with individual projects and by the work of large number of dedicated, motivated, and hard-working students, these different publications were possible. A large number of students who graduated from this lab are actively engaged in research activities in companies, research institutes, research labs, universities both in India and abroad. 


Recent Publications: Last 5 years [20]

Current Research work: (2019-2023)

Current and future work involves, understanding inter organellar communication and protein-protein interactions (UGC-SAP), lysosomal enzyme targeting mechanisms in invertebrates with special emphasis on Hydra Vulgaris (DST-SERB), Proteomics of the protein body components from Trichosanthes anguina seeds (UGC-Mid Career Award), and other non-legume seeds. Further exploring the lysosomal biogenesis in the human lacrimal system (LVPEI collaboration), preparation and characterization and application of plant lectin, phosphorylated mannooligosaccharide nanoparticles towards utilizing them as tools for drug delivery.

 

Internationalization at the UoH, as Director International Affairs


Developed and Coordinated the First International research Training Group in Molecular and Cellular Glycosciences with UoH and University of Muenster, Germany (2009-2017). MoU has been extended second time with the University of Muenster,  and currently coordinator of the same. Coordinating regularly visits of University of Muenster undergraduate students to UoH (SLS and Chemistry School) for 3 month project works.

Actively collaborated with Prof. Hans in Academia Sinica as part of UoH-AS collaborative program with SLS. 

As Director of International Affairs, strenghtened Internationalization in the UoH and has been coordinating several programs of the MHRD at the UoH. Furthermore, also coordinating DAAD supported NAMASTE + Program with University of Goettingen. In the last two years a number of initiatives with international Universities have been formulated at the UoH as MoU's which should in the future facilitate exchange of students and faculties.



No Records Available

Students/Projects Trainees

Name Joined As Mail Contact
Lakshmi Surekha Krishnapati DST-NPDF --- ---
Kowshik K Research Associate in DST-SERB Project --- ---
V Leela Sivaranjani UGC Kothari Postdoctoral Fellow --- ---
Rohit Sai Reddy Konada Project Fellow UGC Mid-Career Award Project --- ---

Former Students/Projects Trainees

Name Joined As Working
Kavyashree SR PhD student DST-INSPIRE Fellow
B.T. Rajasekhar PhD Student
Y. Udaya Lakshmi PhD Student Research Director- Baltimore, USA
Y. Radha PhD Student
K. Suresh PhD Student
V. Suryanarayana Raju PhD Student
V. Lavanyalatha PhD Student
R. Nagender Rao PhD Student
Y. Sivaramakrishna PhD Student
A. Praveen Kumar PhD Student
T. Kiran Kumar PhD Student
Merino Visa PhD Student
Mohammad Mansour Saleh Saif PhD Student
Ashapogu Venugopal PhD Student Patent examiner, Ministry of Commerce, Govt. of India, Chennai
B.S. Gnanesh Kumar PhD Student Scientist at CFTRI, Mysuru
Ismail Khan PhD student
Ajith Kumar A PhD Student DBT Postdoctoral fellow, IISc Bengaluru
Poorna Manasa B PhD Student Research scientist, Dubai
Dr. Mohammad Javed Ali PhD Student Head Dacryology, LVPEI, Hyderabad
Rohit Sai Reddy Konada PhD Student
Mohammad Ahmad Moidduin Fellow - UPE Project
N. Pavan Kumar Reddy UGC Kothari-Postdoc Postdoctoral fellow in Academia Sinica, Taiwan
95 Konada, Rohit Sai Reddy., Krishnapati, Lakshmi Surekha., Ashapogu, Venugopal., Lin, Chung-Hung., Nadimpalli, Siva Kumar., (2020) , Comparative analysis of β-hexosaminidase and acid phosphatase from Hydra vulgaris Ind-Pune, H. vulgaris Naukuchiatal and H. magnipapillata sf-1: Localization studies of acid phosphatase and β-hexosaminidase from H. vulgaris Ind-Pune , Comparative Biochemistry and Physiology Part B: Biochemistry and Molecular Biology, Pergamon,239,,110365.
94 Venugopal, Ashapogu., Mondal, Saradamoni., Ranganatha, Kavyashree Sakharayapatna., Datta, Debparna., Kumar, Nadimpalli Siva., Swamy, Musti J., (2020) , Purification and biochemical/biophysical characterization of two hexosaminidases from the fresh water mussel, Lamellidens corrianus , International Journal of Biological Macromolecules, Elsevier,149,,754-766.
93 Konada, Rohit Sai Reddy., Venugopal, A., Nadimpalli, Siva Kumar., (2020) , Purification, biochemical and biophysical characterization of lysosomal β-D-glucuronidase from an edible freshwater mussel, Lamellidens corrianus , International Journal of Biological Macromolecules, Elsevier,152,,465-472.
92 Krishnapati Lakshmi Surekha1,2*, Samiksha Khade1, Diptee Trimbake1, Rohan Patwardhan1, Siva Kumar Nadimpalli2, Surendra Ghaskadbi1* (2020) , Differential expression of BMP inhibitors gremlin and noggin in Hydra suggests distinct roles during budding and patterning of tentacles , Developmental Dynamics, Wiley,DOI10.1002/dvdy.238,,IF - 3.25.
91 Krishnapati, LS., Khade, S., Trimbake, D., Patwardhan, R., Nadimpalli, SK., Ghaskadbi, S., (2019) , Differential expression of BMP antagonists, gremlin and noggin in hydra: antagonism between Wnt and BMP pathways , , ,,,.
90 Sakharayapatna Ranganatha, Kavyashree., Venugopal, Ashapogu., Nadimpalli, Siva Kumar., (2019) , Class II α-mannosidase from Trichosanthes anguina (Snake Gourd) seeds: Purification and biochemical characterization , , ,,,.
89 Ranganatha, Kavyashree Sakharayapatna., Sahoo, Lipsa., Venugopal, Ashapogu., Nadimpalli, Siva Kumar., (2019) , Purification, biochemical and biophysical characterization of a zinc dependent α-mannosidase isoform III from Custard Apple (Annona squamosa) seeds , International journal of biological macromolecules, Elsevier,138,,1044-1055.
88 Surekha, Krishnapati Lakshmi., Khade, Samiksha., Trimbake, Diptee., Patwardhan, Rohan., Nadimpalli, Siva Kumar., Ghaskadbi, Surendra., (2019) , Differential expression of BMP antagonists, gremlin and noggin in hydra: antagonism between Wnt and BMP pathways , bioRxiv, Cold Spring Harbor Laboratory,,,510602.
87 Kumar, Ajith., Nadimpalli, Siva Kumar., (2018) , Takifugu rubripes cation independent mannose 6-phosphate receptor: Cloning, expression and functional characterization of the IGF-II binding domain , International journal of biological macromolecules, Elsevier,113,,59-65.
86 Bhamidimarri, Poorna Manasa., Krishnapati, Lakshmi Surekha., Ghaskadbi, Surendra., Nadimpalli, Siva Kumar., (2018) , Mannose 6‐phosphate‐dependent lysosomal enzyme targeting in hydra: a biochemical, immunological and structural elucidation , Febs Letters, ,592,8,1366-1377.
85 Ali, Mohammad Javed., Schicht, Martin., Heichel, Jens., Nadimpalli, Siva Kumar., Paulsen, Friedrich., (2018) , Electron microscopic features of the lacrimal sac mucopeptide concretions , Graefe\'s Archive for Clinical and Experimental Ophthalmology, Springer Berlin Heidelberg,256,7,1313-1318.
84 Kumar, Aravindakshan Ajith., Kumar, Nadimpalli Siva., (2018) , Biochemical Characterization of a Lysosomal α-Mannosidase from the Starfish Asterias rubens , The protein journal, Springer US,37,4,361-368.
83 Ali, MJ, Venugopal, A., Kavyashree and Siva Kumar, N., (2018) , Lysosomal enzymatic assays and M6P receptors of the human lacrimal sacs , Indian Journal of Opthalmology, AIOS,,,.
82 Ali MJ, Kumar NS, Brauer L, Paulsen F and Schicht M., (2018) , Expression of Surfactant Proteins in the Human Canaliculus: Evidence and Potential Insights into the Tear Flow Dynamics , Ophthal Plast Reconstr Surg, Wolters Kluwer,,,.
81 Ismail Khan, Ashapogu Venugopal and Nadimpalli Siva Kumar., (2018) , Development of oligosaccharide/sugar coupled Fe3O4 nanoparticle matrices-Potential use in the purification of lectins and glycoproteins , International Journal of Current Medical and Pharmaceutical Research, MCI,4,6,3398-3404.
80 Ali, MJ, Venugopal, A, Kavyashree, S.R, Jagannadham, M.V., and Siva Kumar, N., (2018) , Soluble Glycoproteins of the Lacrimal Sac: Role in Defense with special Reference to Prolactin Inducible Protein (PIP) , ORBIT, Taylor and Frances,,,.
79 Ali, Mohammad Javed., Venugopal, Ashapogu., Ranganath, Kavyashree Sakharayapatna., Kumar, Nadimpalli Siva., (2018) , Lysosomal enzymes and mannose 6-phosphate receptors in the lacrimal drainage system: Evidence and its potential implications , Indian journal of ophthalmology, Wolters Kluwer--Medknow Publications,66,11,1595.
78 Aravindakshan, Ajith Kumar., Nareddy, Pavan Kumar., Kumar, Nadimpalli Siva., (2017) , Affinity Purification of a New Lactose Specific Lectin from Asterias rubens and its Specific Interaction with Cation Independent Mannose 6-phosphate Receptor. , Trends in Carbohydrate Research, ,9,2,.
77 Venugopal, A., Kumar, C Sudheer., Kumar, Nadimpalli Siva., Swamy, Musti J., (2017) , Kinetic and biophysical characterization of a lysosomal α-L-fucosidase from the fresh water mussel, Lamellidens corrianus , International Journal of Biological Macromolecules, Elsevier,104,,432-441.
76 Reddy, Konada RS., Kumar, Vinay., Prasad, Majeti NV., Kumar, Nadimpalli S., (2017) , Moringa oleifera (drumstick tree) seed coagulant protein (MoCP) binds cadmium-preparation and characterization of nanoparticles , The EuroBiotech Journal, Sciendo,1,4,285-292.
75 Venugopal, Ashapogu., Gnanesh Kumar, Belur Shivappa., Ahamad Mohiddon, Mahamad., Ghanashyam Krishna, Mamidipudi., Siva Kumar, Nadimpalli., (2016) , Facile synthesis of biodegradable affinity-purified lectin nanoparticles , Cogent Chemistry, Taylor & Francis,2,1,1230951.
74 Siva Kumar, N, Venugopal, A and Poorna Manasa, B., (2016) , Lysosomal Biogenesis in invertebrates , Science Spectrum, ,1,3,331-338.
73 Siva Kumar, Nadimpalli., M Bhamidimarri, Poorna., (2015) , Lysosomal enzymes and their receptors in invertebrates: an evolutionary perspective , Current Protein and Peptide Science, Bentham Science Publishers,16,1,49-65.
72 Thoele, C., Koenig, S., Kumar, NS., Hensel, A., (2015) , Glycosylated compounds from immature okra fruits inhibit the adhesion of Helicobacter pylori to gastric cells , Planta Medica, ,81,16,SL2B_02.
71 Venugopal, Ashapogu., Kumar, Nadimpalli Siva., (2014) , Biochemical characterization of cathepsin D from the mussel Lamellidens corrianus , Comparative Biochemistry and Physiology Part B: Biochemistry and Molecular Biology, Elsevier,169,,25-30.
70 Tejavath, Kiran Kumar., Nadimpalli, Siva Kumar., (2014) , Purification and characterization of a class II α-Mannosidase from Moringa oleifera seed kernels , Glycoconjugate journal, Springer,31,6-7,485-496.
69 Gnanesh Kumar, BS., Pohlentz, Gottfried., Schulte, Mona., Mormann, Michael., Siva Kumar, Nadimpalli., (2014) , Jack bean α-mannosidase: amino acid sequencing and N-glycosylation analysis of a valuable glycomics tool , Glycobiology, Oxford University Press,24,3,252-261.
68 Kumar, Gnanesh., Pohlentz, Gottfried., Schulte, Mona., Mormann, Michael., Nadimpalli, Siva Kumar., (2014) , N-glycan analysis of mannose/glucose specific lectin from Dolichos lablab seeds , International journal of biological macromolecules, Elsevier,69,,400-407.
67 Saif, Mohammad Mansour Saleh., Khan, Ismail., Prasad, MNV., Kumar, N Siva., (2014) , Preparation and Characterization of Strychnos potatorum L. seed polysaccharide nanoparticles and affinity matrices: relevance to biological applications , Advanced Science, Engineering and Medicine, American Scientific Publishers,6,3,318-325.
66 Mohammad Mansour Saleh Saif, Siva Kumar, N and Prasad, M N V., (2014) , Plant based excipients - The case of Strychnos potatorum seed polysaccharide nanoparticles , Pharma Bio World, ,,,44-48.
65 Sarvamangala, D, Kantipriya, K, Murthy, U S N, Narasinga Rao, B and Siva Kumar, N., (2014) , Green synthesis of silver NPs using Alternantheras Sessilis leaf extract (A natural source for Ocular Therapy) , International Journal of Innovative Research in Science, Engineering and Technology, ,7,3,15000-15010.
64 Venugopal, Ashapogu., Sivakumar, Nadimpalli., (2013) , Isolation, purification, and biochemical characterization of two forms of lysosomal β-N-acetylhexosaminidase from the invertebrate unio , Bioscience, biotechnology, and biochemistry, Japan Society for Bioscience, Biotechnology, and Agrochemistry,,,120707.
63 Shetty, Kartika N., Latha, Vakada Lavanya., Rao, Rameshwaram Nagender., Nadimpalli, Siva Kumar., Suguna, Kaza., (2013) , Affinity of a galactose‐specific legume lectin from Dolichos lablab to adenine revealed by X‐ray cystallography , IUBMB life, ,65,7,633-644.
62 Tejavath, Kiran Kumar., Nadimpalli, Siva Kumar., (2013) , Purification and biochemical characterization of an acidic α-galactosidase from the Moringa oleifera seeds. , Trends in Carbohydrate Research, ,5,2,.
61 Kumar, BS Gnanesh., Pohlentz, G., Mormann, M., Kumar, N Siva., (2013) , Characterization of α-mannosidase from Dolichos lablab seeds: partial amino acid sequencing and N-glycan analysis , Protein expression and purification, Academic Press,89,1,7-15.
60 Visa, Merino., Hammer, Elke., Völker, Uwe., Koliwer-Brandl, Hendrik., Kelm, Sørge., Nadimpalli, Siva Kumar., (2012) , Purification and biochemical characterization of a lysosomal α-fucosidase from the deuterostomia Asterias rubens , Biochimie, Elsevier,94,5,1199-1205.
59 Merino, Visa., Kumar, Nadimpalli Siva., (2012) , Isolation, affinity purification and biochemical characterization of a lysosomal cathepsin D from the deuterostome Asterias rubens , Comparative Biochemistry and Physiology Part B: Biochemistry and Molecular Biology, Elsevier,161,3,240-246.
58 Vegiraju, Suryanarayanaraju., Koduru, Suresh., Nadimpalli, Siva Kumar., (2012) , Lysosomal Enzyme Sorting Receptors—Where Did They First Appear in the Animal Kingdom? , Biochemical Roles of Eukaryotic Cell Surface Macromolecules, Springer,,,67-82.
57 Saif, Mohammad Mansour Saleh., Kumar, N Siva., Prasad, MNV., (2012) , Binding of cadmium to Strychnos potatorum seed proteins in aqueous solution: adsorption kinetics and relevance to water purification , Colloids and Surfaces B: Biointerfaces, Elsevier,94,,73-79.
56 Renke, J., Deters, A., Kumar, NS., (2012) , Isolation and characterization of an arabinose-specific lectin from the ascomycete Xylaria hypoxylon , Planta Medica, ,78,11,PI457.
55 Mohammad Mansour Saleh Saif, Siva Kumar, N and Prasad, M N V., (2012) , Biosorption of cadmium by Strychnos potatorum seed proteins adsorption kinetics Protein nanoparticles for enhancing Cadmium removal and relevance to waste water treatment , Libyan Agriculture Research Centre Journal International, ,3,6,269-278.
54 Khan, Ismail., Kumar, N Siva., (2011) , Mannose 6-Phosphate Containing Nanoparticles: Preparation, Characterization and Interaction with Cation Independent Mannose 6-Phosphate/IGF-II Receptor (MPR300) , Journal of Bionanoscience, American Scientific Publishers,5,2,113-121.
53 Tabosa-Vaz, Sacha., Kumar, Ajit., Permaul, Kugen., Singh, Suren., (2011) , Purification and biochemical characterization of a xylanase purified from a crude enzyme extract for the determination of active site residues , African Journal of Biochemistry Research, Academic Journals,5,2,43-56.
52 Yadavalli, Sivaramakrishna., Nadimpalli, Siva Kumar., (2010) , Role of cation independent mannose 6-phosphate receptor protein in sorting and intracellular trafficking of lysosomal enzymes in chicken embryonic fibroblast (CEF) cells , Glycoconjugate journal, Springer,27,1,39-48.
51 Nadimpalli, SK., Amancha, PK., (2010) , Evolution of mannose 6-phosphate receptors (MPR300 and 46): lysosomal enzyme sorting proteins , Current Protein and Peptide Science, Bentham Science Publishers,11,1,68-90.
50 Kiran Kumar, T and Siva Kumar, N., (2010) , Understanding the roles of proteins in plant seeds with gel electrophoresis , Separation Science, ,2,2,20-26.
49 Kiran Kumar, T Sampurna, A and Siva Kumar, N., (2010) , A new method for the isolation of a galactose specific lectin from Moringa oliefera seeds - Affinity purification and characterization , Separation Science, ,3,6,1-6.
48 Sivaramakrishna, Yadavalli., kumar Amancha, Praveen., Kumar, Nadimpalli Siva., (2009) , Reptilian MPR 300 is also the IGF-IIR: Cloning, sequencing and functional characterization of the IGF-II binding domain , International journal of biological macromolecules, Elsevier,44,5,435-440.
47 Kumar, Amit., Singhal, Nitin K., Ramanujam, Balaji., Mitra, Atanu., Rameshwaram, Nagender R., Nadimpalli, Siva K., Rao, Chebrolu P., (2009) , C 1-/C 2-aromatic-imino-glyco-conjugates: experimental and computational studies of binding, inhibition and docking aspects towards glycosidases isolated from soybean and jack bean , Glycoconjugate journal, Springer,26,4,495-510.
46 Amancha, Praveen Kumar., Dissous, Colette., Nadimpalli, Siva Kumar., (2009) , Characterization of the mannose 6-phosphate receptor (Mr 300 kDa) protein dependent pathway of lysosomal enzyme targeting in Biomphalaria glabrata mollusc cells , Biochimie, Elsevier,91,8,982-988.
45 Rameshwaram, Nagender Rao., Karanam, Narasimha Kumar., Scharf, Christian., Völker, Uwe., Nadimpalli, Siva Kumar., (2009) , Complete primary structure of a newly characterized galactose-specific lectin from the seeds of Dolichos lablab , Glycoconjugate journal, Springer,26,2,161.
44 Rameshwaram, Nagender Rao., Nadimpalli, Siva Kumar., (2008) , An efficient method for the purification and quantification of a galactose-specific lectin from vegetative tissues of Dolichos lablab , Journal of Chromatography B, Elsevier,861,2,209-217.
43 Yadavalli, Sivaramakrishna., Nadimpalli, Siva Kumar., (2008) , Mannose-6-phosphate receptors (MPR 300 and 46) from the highly evolved invertebrate Asterias rubens (Echinodermate): biochemical and functional characterization of MPR 46 protein , Glycoconjugate journal, Springer,25,9,889-901.
42 Amancha, Praveen Kumar., Nadimpalli, Siva Kumar., (2008) , Molecular cloning, expression and functional characterization of the chicken cation dependent mannose 6-phosphate receptor protein , International journal of biological macromolecules, Elsevier,43,3,300-306.
41 RAMESHWARAM, Nagender Rao., NADIMPALLI, Siva Kumar., (2008) , Acta Crystallogr. Sect. F: Struct. Biol. Cryst. Commun. Acta Crystallogr. Sect. F: Struct. Biol. Cryst. Commun. 62, 163, 2006 , Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, ,861,2,209-217.
40 Amancha, Praveen Kumar., Koduru, Suresh., Nadimpalli, Siva Kumar., (2007) , Biochemical and functional characterization of cation dependent (Mr 46,000) goat mannose 6-phosphate receptor , Glycoconjugate journal, Springer,24,4-5,221-229.
39 Koduru, Suresh., Vegiraju, Suryanarayana Raju., Nadimpalli, Siva Kumar., von Figura, Kurt., Pohlmann, Regina., Dennes, André., (2006) , The early vertebrate Danio rerio Mr 46000 mannose-6-phosphate receptor: biochemical and functional characterisation , Development genes and evolution, Springer,216,3,133-143.
38 Latha, Vakada Lavanya., Rao, Rameshwaram Nagender., Nadimpalli, Siva Kumar., (2006) , Affinity purification, physicochemical and immunological characterization of a galactose-specific lectin from the seeds of Dolichos lablab (Indian lablab beans) , Protein Expression and Purification, Academic Press,45,2,296-306.
37 Sultan, Nabil Ali Mohammed., Rao, Rameshwaram Nagender., Nadimpalli, Siva Kumar., Swamy, Musti J., (2006) , Tryptophan environment, secondary structure and thermal unfolding of the galactose-specific seed lectin from Dolichos lablab: fluorescence and circular dichroism spectroscopic studies , Biochimica et Biophysica Acta (BBA)-General Subjects, Elsevier,1760,7,1001-1008.
36 Koduru, Suresh., Yadavalli, Sivaramakrishna., Nadimpalli, Siva Kumar., (2006) , Mannose 6-phosphate receptor (MPR 300) proteins from goat and chicken bind human IGF-II , Bioscience reports, Springer US,26,2,101-112.
35 Lavanya Latha, V, Kulkarni, K, Nagender Rao, R, Siva Kumar, N and Suguna, K., (2006) , Crystallization and preliminary crystallographic analysis of a galactose specific lectin from Dolichos lablab , ACTA Crystallographia F, ,62,,163-165.
34 Kumar, N Ch., Balyan, HS., Gupta, RK., Gupta, PK., (2006) , Genetic analysis of grain protein content in bread wheat [Triticum aestivum L.; India] , Journal of Genetics and Breeding (Italy), ,,,.
33 Srinivas, Oruganti., Radhika, S., Bandaru, Narasimha Murthy., Nadimpalli, Siva Kumar., Jayaraman, Narayanaswamy., (2005) , Synthesis and biological evaluation of mannose-6-phosphate-coated multivalent dendritic cluster glycosides , Organic & Biomolecular Chemistry, Royal Society of Chemistry,3,23,4252-4257.
32 Dennes, André., Cromme, Christoph., Suresh, Koduru., Kumar, Nadimpalli Siva., Eble, Johannes A., Hahnenkamp, Anke., Pohlmann, Regina., (2005) , The novel Drosophila lysosomal enzyme receptor protein mediates lysosomal sorting in mammalian cells and binds mammalian and Drosophila GGA adaptors , Journal of Biological Chemistry, ASBMB,280,13,12849-12857.
31 Nadimpalli, Siva Kumar., Padmanabhan, Nirmala., Koduru, Suresh., (2004) , Biochemical and immunological characterization of a glycosylated α-fucosidase from the invertebrate Unio: interaction of the enzyme with its in vivo binding partners , Protein expression and purification, Elsevier,37,2,279-287.
30 Suresh, Koduru., Nadimpalli, Siva Kumar., (2003) , An immuno-affinity method for the purification of mannose 6-phosphate receptor proteins , Journal of biochemical and biophysical methods, Elsevier,57,3,237-245.
29 Suresh, Koduru., Vegiraju, Suryanarayana Raju., Nadimpalli, Siva Kumar., (2003) , Molecular cloning of goat Mannose 6-phosphate receptors, MPR 300 and 46 , Glycoconjugate journal, Springer,20,4,257-265.
28 Radha, Y and Siva Kumar, N., (2003) , Isolation of a new lactose specific lectin from the invertebrate mollusc Unio , International J of Biochromatography, ,,,.
27 Suresh, Koduru., Ramanadham, Madduri., Nadimpalli, Siva Kumar., (2002) , An ELISA method to quantify the mannose 6-phosphate receptors , Journal of biochemical and biophysical methods, Elsevier,52,2,111-119.
26 Tulasi, Rajasekhar Baru., Nadimpalli, Siva Kumar., (2002) , Purification and characterization of a galactose-specific lectin from the stems and leaves of Dolichos lablab (Indian lablab beans) , Current Science, Current Science Association,,,1005-1009.
25 Kumar Nadimpalli, Siva., von Figura, Kurt., (2002) , Identification of the putative mannose 6-phosphate receptor (MPR 46) protein in the invertebrate mollusc , Bioscience reports, Portland Press Ltd.,22,5-6,513-521.
24 Rajasekhar, B T and Siva Kumar N., (2002) , Purification and characterization of a galactose specific lectin from the stems and leaves of Dolichos lablab (Indian lablab beans) , Current Science, ,82,,1005-1009.
23 Raju, V S N, von Figura, K and Siva Kumar, N., (2001) , Mannose 6-phosphate receptor (MPR300) like polypeptides in the arthropods and Annelidae , Glycoconjugate J, Springer,18,,C2.10.
22 Yerramalla, Udaya Lakshmi., Nadimpalli, Siva Kumar., Schu, Peter., von Figura, Kurt., Hille-Rehfeld, Annette., (2000) , Conserved cassette structure of vertebrate Mr 300 kDa mannose 6-phosphate receptors: partial cDNA sequence of fish MPR 300 , Comparative Biochemistry and Physiology Part B: Biochemistry and Molecular Biology, Elsevier,127,4,433-441.
21 Padma, P., Komath, Sneha Sudha., Nadimpalli, Siva Kumar., Swamy, Musti J., (1999) , Purification in high yield and characterisation of a new galactose-specific lectin from the seeds of Trichosanthes cucumerina , Phytochemistry, Elsevier,50,3,363-371.
20 Nadimpalli, Siva Kumar., Yerramalla, Udaya Lakshmi., Hille-Rehfeld, Annette., von Figura, Kurt., (1999) , Mannose 6-phosphate receptors (MPR 300 and MPR 46) from a teleostean fish (trout) , Comparative Biochemistry and Physiology Part B: Biochemistry and Molecular Biology, Elsevier,123,3,261-265.
19 Nadimpalli, Siva Kumar., (1999) , Chemical modification studies on the glucose/mannose specific lectins from field and lablab beans , IUBMB Life, Informa Healthcare UK,47,5,825-834.
18 Lakshmi, Yerramalla Udaya., Radha, Yalamarthy., Hille-Rehfeld, Annette., von Figura, Kurt., Kumar, Nadimpalli Siva., (1999) , Identification of the putative mannose 6-phosphate receptor protein (MPR 300) in the invertebrate unio , Bioscience reports, Portland Press Ltd.,19,5,403-409.
17 Lakshmi, Yerramalla Udaya., Radha, Yalamarthy., Hille-Rehfeld, Annette., Figura, Kurt von., Kumar, Nadimpalli Siva., (1999) , Biochemical Roles of Eukaryotic Cell Surface Macromolecules-SHORT PAPERS-Identification of the Putative Mannose 6-phosphate Receptor Protein (MPR 300) in the Invertebrate unio , Bioscience Reports-Short Papers and Reviews in Molecular and Cellular Biology, London: Biochemical Society, c1981-,19,5,403-410.
16 Komath, Sneha Sudha., Nadimpalli, Siva Kumar., Swamy, Musti J., (1998) , Identification of histidine residues in the sugar binding site of snake gourd (Trichosanthes anguina) seed lectin , IUBMB Life, Informa Healthcare UK,44,1,107-116.
15 Tulasi, Rajasekhar Baru., Nadimpalli, Siva Kumar., (1998) , A new unusual galactose-specific lectin from the seeds of Indian lablab beans , Current Science, Current Science Association,,,840-842.
14 Tulasi, Rajasekhar Baru., Nadimpalli, Siva Kumar., (1997) , Purification of α‐mannosidase activity from Indian lablab beans , IUBMB Life, Informa Healthcare UK,41,5,925-931.
13 Nadimpalli, Siva Kumar., Hille-Rehfeld, Annette., von Figura, Kurt., (1997) , Mannose 6-phosphate receptor proteins from reptiles and amphibians: evidence for the presence of MPR 300 and MPR 46 , Comparative Biochemistry and Physiology Part B: Biochemistry and Molecular Biology, Elsevier,118,4,805-809.
12 TULASI, RAJASEKHAR BARU., Potturi, P., NADIMPALLI, SIVA KUMAR., (1997) , PURIFICATION OF A LECTIN IN HIGH YIELD FROM THE INDIAN LABLAB BEANS ON GOAT IGM SEPHAROSE AND BY IMMUNOAFFINITY CHROMATOGRAPHY: EVIDENCE FOR THE PRES ENCE OF ENDOGENOUS LECTIN RECEPTORS , Biochemical archives, MBR Press,13,4,237-244.
11 Nadimpalli, SK., Yerramalla, UL., (1997) , An efficient and rapid protocol for the purification and separation of mannose 6-phosphate receptor proteins (MPR 300 and MPR 46) , EUROPEAN JOURNAL OF CELL BIOLOGY, WISSENSCHAFTLICHE VERLAG MBH BIRKENWALDSTRASSE 44, POSTFACH 10 10 61, 70009 …,74,,116-116.
10 Nadimpalli, SK., HilleRehfeld, A., vonFigura, K., (1997) , Biochemical and immunological evidence for the presence of MPR proteins (MPR 300 and MPR 46) in fish , EUROPEAN JOURNAL OF CELL BIOLOGY, WISSENSCHAFTLICHE VERLAG MBH BIRKENWALDSTRASSE 44, POSTFACH 10 10 61, 70009 …,74,,66-66.
9 Komath, Sneha Sudha., Nadimpalli, Siva Kumar., Swamy, Musti J., (1996) , Purification in high yield and characterisation of the galactose‐specific lectin from the seeds of snake gourd (Trichosanthes anguina) , IUBMB Life, Informa Healthcare UK,39,2,243-252.
8 Nadimpalli, Siva Kumar., Kompella, Padma., (1996) , Affinity purification of N-acetylglucosamine specific lectins. Purification and partial charactersation of triticale lectin. , Biochemistry and molecular biology international, ,38,5,1059-1066.
7 Kumar, Nadimpalli Siva., (1996) , An affinity method for the purification of mannose 6-phosphate receptor proteins (MPR 215) from rat tissues and goat liver , Journal of biochemical and biophysical methods, Elsevier,31,3-4,181-184.
6 Yerramalla, Udaya Lakshmi., Nadimpalli, Siva Kumar., (1996) , Affinity purification of mannose 6‐phosphate receptor proteins. Purification and partial characterisation of goat liver receptors , IUBMB Life, Informa Healthcare UK,40,4,815-821.
5 Schulze-Garg, Christine., Böker, Christian., Nadimpalli, S Kumar., von Figura, Kurt., Hille-Rehfeld, Annette., (1993) , Tail-specific antibodies that block return of 46,000 M (r) mannose 6-phosphate receptor to the trans-Golgi network , The Journal of cell biology, ,122,3,541-551.
4 Gersberlag, H, Sc hecher, G, Siva Kumar, N and Ruideger, H., (1993) , Protein body membranes as binding partners of lectins , Lectins in Biology, Biochemistry and Clinical Biochemistry, ,8,,97-100.
3 Nadimpalli, Siva Kumar., Schmidt, Bernhard., von Figura, Kurt., Hille, Annette., (1991) , Antibodies against the cytoplasmic tail can differentiate between the quaternary forms of the M r 46000 mannose 6‐phosphate receptor , FEBS letters, ,280,1,61-64.
2 SCHULZEGARG, G., NADIMPALLI, SK., VONFIGURA, K., HILLE, A., (1991) , A TAIL-SPECIFIC ANTIBODY BLOCKS TRANSPORT OF THE 46 KDA MANNOSE 6-PHOSPHATE RECEPTOR (MPR-46) , BIOLOGICAL CHEMISTRY HOPPE-SEYLER, WALTER DE GRUYTER & CO GENTHINER STRASSE 13, D-10785 BERLIN, GERMANY,372,9,752-752.
1 Kumar, N Siva., Rao, D Rajagopal., (1986) , The nature of lectins fromDolichos lablab , Journal of Biosciences, Springer India,10,1,95-109.
Title Year Duration Amount(In Lakhs) PI/I
Quantitative proteomics of Protein Body components (lectins and glycosidases), from the Trichosanthes anguina seeds: elucidation of protein-protein interactions in the protein body biogenesis 2019 2 Years 10 Prof. N. Siva Kumar
Biochemical investigation of endosomal targeting proteins and functional analysis of lysosomal enzymes and their receptors in Hydra 2019 3 Years 58 Prof. N. Siva Kumar