Faculty Details

Faculty Details

  • Name: Prof. Gutti Ravi Kumar
  • Mail: guttiravigmail.com
  • Contact: 914023134533
  • Area Of Research:Stem cells, Developmental Biology, Epigenetics, Signal Transduction, Regenerative and Translational medicine
Prof. Ravi Gutti holds a Ph.D. in Molecular Biology and Biotechnology from Indian Agricultural Research Institute, New Delhi. He has extensive research and teaching experience from Harvard Medical School (USA), National Institutes of Health (USA), Moffitt Cancer and Research Center (USA) and RWTH Aachen (Germany). His expertise is in gene regulation and stem cell biology. His current research is focused on understanding the molecular regulation of developmental megakaryocytopoiesis (platelet production) with emphasis on the role of non-coding RNA.  He would like to explore the mechanisms regulating the developmental changes in miRNA and lncRNA expression, which are currently not understood. 
No Records Available

Students/Projects Trainees

Name Joined As Mail Contact
Sanjeev Raghuwanshi PhD Student snjv.intelligencecommonsense@gmail.com 919910588740
Narasaiah Kovuru PhD Student kpnbhu@gmail.com 916300363279
Durga Shankar Sharma PhD Student durgashankarsharma21@gmail.com 917893314275
Swati Dahariya PhD Student swati.dahariya@gmail.com 919491949330
Dushyant Kumar PhD Student kumardushyant816@gmail.com 916392241030
Indira Paddibhatla WOS-A Scientist paddibhatla@gmail.com 916302426203

Former Students/Projects Trainees

Name Joined As Working
Ram Babu Undi PhD Student University of Oklahoma Health Sciences Center, Department of Physiology, Oklahoma City, USA
Ravinder Kandi PhD Student Laboratory of Prof. Dr. Hartmut Geiger, Director, Institute of Molecular Medicine and Stem Cell Aging, Universität Ulm, Germany
Shilpa Sarvothaman MSc Project Student Clinical project coordinator
Som Dutta Paul MSc Biochemistry Project Student PhD Student at IISER Tirupati
Som Dutta Paul MSc Biochemistry Project Student PhD Student at IISER Tirupati
Aishwarya Jaiswal MSc Biochemistry Project Student Currently doing PhD in Jawaharlal Nehru University, New Delhi under Prof. Rana
Vikas Arige MSc Biochemistry Project Student Complete PhD from IIT Madras and currently pursuing Postdoc at University of Rochester
Rashi Agarwal BTech Project Student Currently pursuing PhD from EMBL Hiedelberg, Germany
Mohit Mishra MSc Biochemistry Project Student Currently pursuing PhD from Jawaharlal Nehru University, New Delhi under Prof. Rakesh Bhatnagar (Vice Chancellor of BHU)
Pooja Ram Mohan MSc Project Student Worked at Enzene Biosciences, Pune and currently working in Amrita fertility centre, Ernakulam
Itishri Sahu PhD Student Currently working in University Clinic Tuebingen, Germany
Satya Ratan Pasupuleti MTech Project Student Currently working for food corporation of india
Satya Ratan Pasupuleti MTech Project Student and Junior Research Fellow Currently working for food corporation of india
Aneesh Kotipalli DBT-IYBA JRF Currently working for Centre for Development of Advanced Computing (C-DAC), Pune
Santosh Kumar MSc Biochemistry Project Student Currently a PhD student in Dr. Seems Mishra Laboratory of Computational Biology at University of Hyderabad
Priyanka Bansal MSc Biochemistry Project Student Currently pursuing PhD in Dr. Christoph F kurat Laboratory in Biomedical Center (BMC), Department of Molecular Biology, LMU, Munich, Germany
Priyanka Dahate MSc Biochemistry Project Student PhD position in ZMBH, Heidelberg University, Heidelberg in Claudio Joazeiro's group.
54 Raghuwanshi, Sanjeev., Sharma, Durga Shankar., Kandi, Ravinder., Kovuru, Narasaiah., Dahariya, Swati., Musvi, Syed Shahid., Venkatakrishnan, Anuradha Chimata., Pallepati, Adithya., Gutti, Ravi Kumar., (2019) , Pituitary adenylate cyclase-activating polypeptide (PACAP): Differential effects on neonatal vs adult megakaryocytopoiesis , Thrombosis research, Elsevier,175,,59-60.
53 Pelzl, L., Sahu, I., Heinzmann, D., Bhuyan, AAM., Marini, I., Rigoni, F., Artunc, F., Sukkar, B., Cao, H., Gutti, R., (2019) , Phosphate-induced ORAI1 Expression and Store Operated Ca2+ Entry in Megakaryocytes , Hämostaseologie, Georg Thieme Verlag KG,39,S 01,SY05-2-AB.
52 Kummari, Githavani., Gutti, Ravi K., Kalle, Arunasree M., (2019) , HDAC6 promotes PMA-induced megakaryocyte differentiation of K562 cells by regulating ROS levels via NOX4 and repressing Glycophorin A , bioRxiv, Cold Spring Harbor Laboratory,,,578096.
51 Kovuru, Narasaiah., Raghuwanshi, Sanjeev., Gutti, Ravi Kumar., (2019) , Exosome mediated differentiation of megakaryocytes: a study on TLR mediated effects , Journal of thrombosis and thrombolysis, Springer US,48,1,171-173.
50 Dahariya, Swati., Paddibhatla, Indira., Kumar, Santosh., Raghuwanshi, Sanjeev., Pallepati, Adithya., Gutti, Ravi Kumar., (2019) , Long non-coding RNA: Classification, biogenesis and functions in blood cells , Molecular immunology, Pergamon,112,,82-92.
49 Raghuwanshi, Sanjeev., Gutti, Usha., Kandi, Ravinder., Gutti, Ravi Kumar., (2018) , Micro RNA?9 promotes cell proliferation by regulating RUNX 1 expression in human megakaryocyte development , Cell proliferation, ,51,1,e12414.
48 Raghuwanshi, Sanjeev., Dahariya, Swati., Kandi, Ravinder., Gutti, Usha., Undi, Ram B., Sharma, Durga Shankar., Sahu, Itishri., Kovuru, Narasaiah., Yarla, Nagendra Sastry., Saladi, Raja GV., (2018) , Epigenetic mechanisms: role in hematopoietic stem cell lineage commitment and differentiation , Current drug targets, Bentham Science Publishers,19,14,1683-1695.
47 Sahu, Itishri., Hebalkar, Rucha., Kar, Sonika., SreeVidya, TS., Gutti, Usha., Gutti, Ravi Kumar., (2018) , Systems biology approach to study the role of miRNA in promoter targeting during megakaryopoiesis , Experimental cell research, Academic Press,366,2,192-198.
46 Bansal, Priyanka., Dahate, Priyanka., Raghuwanshi, Sanjeev., Sharma, Durga S., Kovuru, Narasaiah., Gutti, Usha., Yarla, Nagendra Sastry., Gutti, RavI Kumar., (2018) , Current Updates on Role of Lipids in Hematopoiesis , Infectious Disorders-Drug Targets (Formerly Current Drug Targets-Infectious Disorders), Bentham Science Publishers,18,3,192-198.
45 Gutti, Usha., Komati, Jaswant Kumar., Kotipalli, Aneesh., Saladi, Raja Gopal Venakata., Gutti, Ravi Kumar., (2018) , Justicia adhatoda induces megakaryocyte differentiation through mitochondrial ROS generation , Phytomedicine, Urban & Fischer,43,,135-139.
44 Raghuwanshi, Sanjeev., Dahariya, Swati., Musvi, Syed Shahid., Gutti, Usha., Kandi, Ravinder., Undi, Ram Babu., Sahu, Itishri., Gautam, Dushyant Kumar., Paddibhatla, Indira., Gutti, Ravi Kumar., (2018) , MicroRNA function in megakaryocytes , Platelets, Taylor & Francis,,,8-Jan.
43 Undi, Ram Babu., Gutti, Usha., Gutti, Ravi Kumar., (2017) , LiCl regulates mitochondrial biogenesis during megakaryocyte development , Journal of Trace Elements in Medicine and Biology, Urban & Fischer,39,,193-201.
42 Sahu, Itishri., Pelzl, Lisann., Sukkar, Basma., Fakhri, Hajar., al-Maghout, Tamer., Cao, Hang., Hauser, Stefan., Gutti, Ravi., Gawaz, Meinrad., Lang, Florian., (2017) , NFAT5-sensitive Orai1 expression and store-operated Ca2+ entry in megakaryocytes , The FASEB Journal, Federation of American Societies for Experimental Biology Bethesda, MD, USA,31,8,3439-3448.
41 Al-Maghout, Tamer., Pelzl, Lisann., Sahu, Itishri., Sukkar, Basma., Hosseinzadeh, Zohreh., Gutti, Ravi., Laufer, Stefan., Voelkl, Jakob., Pieske, Burkert., Gawaz, Meinrad., (2017) , P38 Kinase, SGK1 and NF-?B Dependent Up-Regulation of Na+/Ca2+ Exchanger Expression and Activity Following TGFß1 Treatment of Megakaryocytes , Cellular Physiology and Biochemistry, Karger Publishers,42,6,2169-2181.
40 Undi, Ram Babu., Gutti, Usha., Sahu, Itishri., Sarvothaman, Shilpa., Pasupuleti, Satya Ratan., Kandi, Ravinder., Gutti, Ravi Kumar., (2016) , Wnt signaling: role in regulation of haematopoiesis , Indian Journal of Hematology and Blood Transfusion, Springer India,32,2,123-134.
39 Undi, Ram Babu., Sarvothaman, Shilpa., Narasaiah, Kovuru., Gutti, Usha., Gutti, Ravi Kumar., (2016) , Toll-like receptor 2 signalling: Significance in megakaryocyte development through wnt signalling cross-talk and cytokine induction , Cytokine, Academic Press,83,,245-249.
38 Undi, Ram Babu., Gutti, Usha., Gutti, Ravi Kumar., (2016) , Role of let-7b/Fzd4 axis in mitochondrial biogenesis through wnt signaling: In neonatal and adult megakaryocytes , The international journal of biochemistry & cell biology, Pergamon,79,,61-68.
37 Gutti, Usha., Pasupuleti, Satya Ratan., Sahu, Itishri., Kotipalli, Aneesh., Undi, Ram Babu., Kandi, Ravinder., Saladi, Raja Gopal Venakata., Gutti, Ravi Kumar., (2016) , Erythropoietin and thrombopoietin mimetics: Natural alternatives to erythrocyte and platelet disorders , Critical reviews in oncology/hematology, Elsevier,108,,175-186.
36 Aneesh Kotipalli, Ravikumar Gutti, Chanchal K Mitra., (2016) , Dynamics of miRNA biogenesis and nuclear transport , Journal of Integrative Bioinformatics, de Gruyter,13,305,.
35 Karnati, Hanuma Kumar., Pasupuleti, Satya Ratan., Kandi, Ravinder., Undi, Ram Babu., Sahu, Itishri., Kannaki, TR., Subbiah, Madhuri., Gutti, Ravi Kumar., (2015) , TLR-4 signalling pathway: MyD88 independent pathway up-regulation in chicken breeds upon LPS treatment , Veterinary research communications, Springer Netherlands,39,1,73-78.
34 Kandi, Ravinder., Gutti, Usha., Saladi, RG., Gutti, Ravi Kumar., (2015) , MiR-125b and miR-99a encoded on chromosome 21 co-regulate vincristine resistance in childhood acute megakaryoblastic leukemia. , Hematology/oncology and stem cell therapy, ,8,2,95.
33 Kandi, Ravinder., Gutti, Usha., Undi, Rambabu., Sahu, Itishri., Gutti, Ravi Kumar., (2015) , Understanding thrombocytopenia: physiological role of microRNA in survival of neonatal megakaryocytes , Journal of thrombosis and thrombolysis, Springer US,40,3,310-316.
32 Sarvothaman, Shilpa., Undi, Ram Babu., Pasupuleti, Satya Ratan., Gutti, Usha., Gutti, Ravi Kumar., (2015) , Apoptosis: role in myeloid cell development , Blood research, ,50,2,73-79.
31 Karnati, Hanuma Kumar., Panigrahi, Manas Kumar., Gutti, Ravi Kumar., Greig, Nigel H., Tamargo, Ian A., (2015) , miRNAs: key players in neurodegenerative disorders and epilepsy , Journal of Alzheimer\'s Disease, IOS Press,48,3,563-580.
30 Karnati, Hanuma Kumar., Raghuwanshi, Sanjeev., Sarvothaman, Shilpa., Gutti, Usha., Saladi, Raja Gopal Venakata., Komati, Jaswant Kumar., Tummala, Prathibha Reddy., Gutti, Ravi Kumar., (2015) , microRNAs: key players in hematopoiesis , microRNA: Basic Science, Springer, Cham,,,171-211.
29 Kandi, Ravinder., Undi, Rambabu., Gutti, Ravi Kumar., (2014) , MiR-125b regulates cell proliferation and survival in neonatal megakaryocytes , Annals of hematology, Springer Berlin Heidelberg,93,6,1065-1066.
28 Ferrer-Marin, Francisca., Gutti, Ravi., Liu, Zhi-Jian., Sola-Visner, Martha., (2014) , MiR-9 contributes to the developmental differences in CXCR-4 expression in human megakaryocytes , Journal of thrombosis and haemostasis: JTH, NIH Public Access,12,2,282.
27 Karnati, Hanuma Kumar., Yalagala, Ravi Shekar., Undi, Rambabu., Pasupuleti, Satya Ratan., Gutti, Ravi Kumar., (2014) , Therapeutic potential of siRNA and DNAzymes in cancer , Tumor biology, Springer Netherlands,35,10,9505-9521.
26 Sahu I, Mishra S, Babu Undi R, Kandi R, Gutti U, Kumar Gutti R., (2014) , Sequence and structural difference favors a distinct preference of Wnt3a binding with co-receptor LRP6. , J Biomol Struct Dyn, Taylor Francis Online,,25,1-33..
25 Undi, Ram Babu., Kandi, Ravinder., Gutti, Ravi Kumar., (2013) , MicroRNAs as haematopoiesis regulators , Advances in hematology, Hindawi,2013,,.
24 Tsai-Morris, Chon-Hwa., Sato, Hisashi., Gutti, Ravi., Dufau, Maria L., (2012) , Role of gonadotropin regulated testicular RNA helicase (GRTH/Ddx25) on polysomal associated mRNAs in mouse testis , PloS one, Public Library of Science,7,3,e32470.
23 Liu, Zhi-Jian., Italiano, Joseph., Ferrer-Marin, Francisca., Gutti, Ravi., Bailey, Matthew., Poterjoy, Brandon., Rimsza, Lisa., Sola-Visner, Martha., (2011) , Developmental differences in megakaryocytopoiesis are associated with up-regulated TPO signaling through mTOR and elevated GATA-1 levels in neonatal megakaryocytes , Blood, American Society of Hematology,117,15,4106-4117.
22 Dufau, Maria L., Sato, Hisashi., Gutti, Ravi., Tsai-Morris, Chon-Hwa., (2011) , Gonadotropin-Regulated Testicular Helicase (GRTH/DDX25): A Master Post-transcriptional Regulator of Spermatogenesis , Hormonal and Genetic Basis of Sexual Differentiation Disorders and Hot Topics in Endocrinology: Proceedings of the 2nd World Conference, Springer, New York, NY,,,23-29.
21 Tsai?Morris, Chon?Hwa., Sheng, Yi., Gutti, Ravi K., Tang, Pei?Zhong., Dufau, Maria L., (2010) , Gonadotropin?regulated testicular RNA helicase (GRTH/DDX25): a multifunctional protein essential for spermatogenesis , Journal of andrology, Blackwell Publishing Ltd,31,1,45-52.
20 Ferrer-Marin, Francisca., Liu, Zhi-Jian., Gutti, Ravi., Sola-Visner, Martha., (2010) , Neonatal thrombocytopenia and megakaryocytopoiesis , Seminars in hematology, WB Saunders,47,3,281-288.
19 Tsai?Morris, Chon?Hwa., Sheng, Yi., Gutti, Ravi., Li, Jie., Pickel, James., Dufau, Maria L., (2010) , Gonadotropin?regulated testicular RNA helicase (GRTH/DDX25) gene: Cell?specific expression and transcriptional regulation by androgen in transgenic mouse testis , Journal of cellular biochemistry, Wiley Subscription Services, Inc., A Wiley Company,109,6,1142-1147.
18 Sallmon, H., Gutti, RK., Ferrer-Marin, F., Liu, ZJ., Sola-Visner, MC., (2010) , Increasing platelets without transfusion: is it time to introduce novel thrombopoietic agents in neonatal care? , Journal of Perinatology, Nature Publishing Group,30,12,765.
17 Ferrer-Marin, Francisca., Gutti, Ravi K., Liu, Zhi-Jian., Italiano, Joseph., Hu, Zhongbo., Slayton, William., Sola-Visner, Martha., (2010) , Neonatal Megakaryocytes Do Not Mature Normally In the Absence of Thrombopoietin In Vivo: Potential Role of Developmental Differences In CXCR4 Expression , , American Society of Hematology,,,.
16 Gutti, Ravi K., Sallmon, Hannes., Liu, Zhi-Jian., Ferrer-Marin, Francisca., Cantor, Alan., Bailey, Matthew., Sola-Visner, Martha., (2010) , Developmental Differences In the Let-7b/IMP-1/IGF-II Axis contribute to the High Proliferative Rate of Neonatal Megakaryocyte Progenitors. , , American Society of Hematology,,,.
15 Gutti, Ravi K., (2010) , Introduction to microRNA , , ,,,.
14 Liu, ZJBM., Bailley, M., Gutti, R., Sallmon, H., Sola-Visner, M., (2009) , Thrombopoietin stimulates the cytoplasmic maturation of low-ploidy neonatal megakaryocytes through the mtor pathway: PP-TH-073 , Journal of Thrombosis and Haemostasis, ,7,,956-957.
13 Gutti, R., Sallmon, H., Bailey, M., Liu, Z., Sola-Visner, M., (2009) , MicroRNA expression signatures are different in human neonatal compared to adult megakaryocytes , Journal of Thrombosis and Haemostasis, ,7,,.
12 Ferrer-Marin, F., Hu, Z., Liu, Z., Slayton, W., Bailey, M., Gutti, R., Sola-Visner, M., (2009) , Megakaryocytopoiesis in c-mpl knockout neonatal versus Adult mice: PP-WE-083 , Journal of Thrombosis and Haemostasis, ,7,,.
11 Gutti, Ravi K., Tsai-Morris, Chon-Hwa., Dufau, Maria L., (2008) , Gonadotropin-regulated testicular helicase (DDX25), an essential regulator of spermatogenesis, prevents testicular germ cell apoptosis , Journal of Biological Chemistry, American Society for Biochemistry and Molecular Biology,283,25,17055-17064.
10 Gutti, Ravi Kumar., Tsai-Morris, Chon-Hwa., Dufau, Maria L., (2008) , Gonadotropin-Regulated Testicular Helicase (GRTH/Ddx25): A Negative Regulator of Apoptosis in Male Germ Cells , , Federation of American Societies for Experimental Biology,,,.
9 Tsai-Morris, Chon-Hwa., Koh, Eitetsu., Sheng, Yi., Maeda, Yuji., Gutti, Ravi., Namiki, Mikio., Dufau, Maria L., (2007) , Polymorphism of the GRTH/DDX25 gene in normal and infertile Japanese men: a missense mutation associated with loss of GRTH phosphorylation , Molecular human reproduction, Oxford University Press,13,12,887-892.
8 Tsai-Morris, Chon-Hwa., Koh, Eitetsu., Sheng, Yi., Maeda, Yuji., Gutti, Ravi., Namiki, Mikio., Dufau, Maria L., (2007) , Revised MHR 07-204 Polymorphism of the GRTH/DDX25 gene in normal and infertile Japanese men: a missense mutation associated with loss of GRTH phosphorylation. , , ,,,.
7 Sheng, Yi., Tsai-Morris, Chon-Hwa., Gutti, Ravi., Maeda, Yuji., Dufau, Maria L., (2006) , Gonadotropin-regulated testicular RNA helicase (GRTH/Ddx25) is a transport protein involved in gene-specific mRNA export and protein translation during spermatogenesis , Journal of Biological Chemistry, American Society for Biochemistry and Molecular Biology,281,46,35048-35056.
6 Bhalla, KN., George, P., Gutti, R., Bali, P., Tao, J., Guo, F., Sigua, C., Li, Y., Cohen, P., Atadja, P., (2004) , A combination of histone deacetylase inhibitor LBH589 and the hsp90 inhibitor 17-AAG is highly active against human CML-BC and AML cells with constitutively active mutant FLT-3 tyrosine kinase , Journal of Clinical Oncology, American Society of Clinical Oncology,22,14_suppl,6541-6541.
5 Gutti, Ravi., George, Prince., Bali, Purva., Tao, Jianguo., Guo, Fei., Sigua, Celia., Li, Yunqing., Moscinski, Lynn., Atadja, Peter., Bhalla, Kapil N., (2004) , A combination of histone deacetylase inhibitor LBH589 and the hsp90 inhibitor 17-AAG is highly active against human CML-BC and AML cells with constitutively active mutant FLT-3 tyrosine kinase. , , American Association for Cancer Research,,,.
4 Guo, Fei., Sigua, Celia., Bali, Purva., George, Prince., Gutti, Ravi., Li, Yunqing., Bhalla, Kapil N., (2004) , Mechanistic link between hsp70 overexpression upregulation of STAT5 and Bcl-xL and resistance to cytarabine, etoposide or Apo-2L/TRAIL-induced apoptosis in Bcr-Abl expressing acute leukemia cells , , American Association for Cancer Research,,,.
3 George, P., Bali, P., Jianguo, T., Vishvanath, A., Guo, F., Sigua, C., Gutti, R., Li, YQ., Moscinski, L., Cohen, P., (2003) , Treatment with heat shock protein-90 inhibitor 17-allyl-demethoxy-geldanamycin (17-AAG) induces proteasomal degradation of mutant FLT-3 and enhances PKC412-mediated apoptosis of human AML cells with constitutively active mutant FLT-3 tyrosine kinase. , Blood, AMER SOC HEMATOLOGY 1900 M STREET. NW SUITE 200, WASHINGTON, DC 20036 USA,102,11,598A-598A.
2 Li, YQ., Guo, F., Sigua, C., Tao, JG., Bali, P., Vishvanath, A., Gutti, R., George, P., Moscinski, L., Atadja, P., (2003) , Combined treatment with histone deacetylase inhibitor LAQ824 and Apo-2L/TRAIL: Mechanistic basis of superior activity against human acute leukemia and CML-BC cells. , Blood, AMER SOC HEMATOLOGY 1900 M STREET. NW SUITE 200, WASHINGTON, DC 20036 USA,102,11,595A-595A.
1 Bali, P., George, P., Tao, JG., Guo, F., Sigua, C., Vishvanath, A., Gutti, R., Li, YQ., Moscinski, L., Cohen, P., (2003) , A combination of historic deacetylase inhibitor LAQ824 and the FLT-3 kinase inhibitor PKC412 is highly active against human AML cells with constitutively active mutant FLT-3 tyrosine kinase. , Blood, AMER SOC HEMATOLOGY 1900 M STREET. NW SUITE 200, WASHINGTON, DC 20036 USA,102,11,96A-97A.
Title Year Duration Amount(In Lakhs) PI/I
Creation of a genetic resource of ........fruit ripening and phosphate starvation response 2019 3 20 PI
Understanding genetic diversity ..... to low phosphate in tomato 2019 3 35 PI