Faculty Details

Faculty Details

  • Name: Dr. Vijay Morampudi
  • Mail: vmorampudivgmail.com
  • Contact: 7702849094
  • Area Of Research:Gut inflammation, host-probiotic-enteric pathogen interactions, inflammatory bowel disease

EDUCATION:

(2011)       PhD in Biomedical and Pharmaceutical Sciences, Université Libre de Bruxelles, Brussels, Belgium.

(2006)       M.S. in Medical and Pharmaceutical Research, Vrije Universiteit Brussel, Brussels, Belgium (Distinction).

(2001)       Bachelor in Pharmacy, Osmania University, Hyderabad, Telangana, India.

EXPERIENCE:

 [Academic tutor and Writer at Acematiks, Inc., QC, CANADA] for PhD professionals (2018-2019).

[Scientist/Biology Lead, Immunology at Engene Inc, QC, CANADA]: Studying the therapeutic efficacy of an immunomodulatory protein in a mouse bladder cancer (2017- 2108)

[Post-doctoral Fellow at University of British Columbia (UBC), Faculty of Medicine, BC, CANADA] : Defining the role of goblet cell secreting factors Resistin like molecule beta (RELM-beta) and Mucin 2 (Muc2) in a mouse model of intestinal inflammation (2011- 2016).

 [PhD at Université Libre de Bruxelles (ULB), Belgium]: Studying the modulation of innate immune responses in intestinal epithelial cells by Toxoplasma gondii and its correlation with parasite virulence (2006-2011).

ACADEMIC AWARDS and HONOURS

•      Michael Smith Foundation Health Research Fellowship (MSFHR), Canada, PDF fellowship (2013 to 2016).

•      Child and Family Research Fellowship (CFRI), Canada (2012).

•      3R Research Foundation, Switzerland, PhD Scholarship (2008 to 2010).

•      Van Buuren Scholarship, Belgium for 3 months.

•      Pasteur Institute of Brussels Scholarship, Belgium (2007).

•      Belgium Immunological Society Travel Award, Belgium (2009).

•      Invited to Chair UBC organized graduate seminar day, Vancouver, Canada (2012 & 2015).

•      Invited poster judge on UBC organized Experimental Medicine day, Vancouver, Canada (2012 to 2015).

•      Invited speaker in International Congress of Mucosal Immunology, Vancouver, Canada (2013).

LICENCES AND CERTIFICATIONS

•      Licensed Pharmacist in India

•      National Institute of Health (NIH) certificate in Clinical Research Training course (2016)

•      Biological safety

•      Canadian Council of Animal Care (CCAC)

•      Rodent Biology and Husbandry

•      Rodent Anesthesia and Surgery

•      Project management

•      Scientific Writing

•      Professional and Business Effectiveness.

  



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16 Allaire, Joannie M., Morampudi, Vijay., Crowley, Shauna M., Stahl, Martin., Yu, Hongbing., Bhullar, Kirandeep., Knodler, Leigh A., Bressler, Brian., Jacobson, Kevan., Vallance, Bruce A., (2018) , Frontline defenders: goblet cell mediators dictate host-microbe interactions in the intestinal tract during health and disease , American Journal of Physiology-Gastrointestinal and Liver Physiology, American Physiological Society Bethesda, MD,314,3,G360-G377.
15 Patankar, Jay V., Wong, Chi K., Morampudi, Vijay., Gibson, William T., Vallance, Bruce., Ioannou, George N., Hayden, Michael R., (2018) , Genetic ablation of Cyp8b1 preserves host metabolic function by repressing steatohepatitis and altering gut microbiota composition , American Journal of Physiology-Endocrinology and Metabolism, American Physiological Society Bethesda, MD,314,5,E418-E432.
14 Sham, Ho Pan., Bazett, Mark., Bosiljcic, Momir., Yang, Hyungjun., Luk, Beryl., Law, Hong T., Morampudi, Vijay., Yu, Hong B., Pankovich, Jim., Sutcliffe, Simon., (2018) , Immune stimulation using a gut microbe-based immunotherapy reduces disease pathology and improves barrier function in ulcerative colitis , Frontiers in immunology, Frontiers,9,,2211.
13 Morampudi, Vijay., Graef, Franziska A., Stahl, Martin., Dalwadi, Udit., Conlin, Victoria S., Huang, Tina., Vallance, Bruce A., Hong, B Yu., Jacobson, Kevan., (2017) , Tricellular tight junction protein tricellulin is targeted by the enteropathogenic Escherichia coli effector EspG1, leading to epithelial barrier disruption , Infection and Immunity, American Society for Microbiology Journals,85,1,.
12 Chung, H., Vilaysane, A., Lau, A., Stahl, M., Morampudi, V., Bondzi-Simpson, A., Platnich, JM., Bracey, NA., French, MC., Beck, PL., (2016) , NLRP3 regulates a non-canonical platform for caspase-8 activation during epithelial cell apoptosis , Cell Death & Differentiation, Nature Publishing Group,23,8,1331-1346.
11 Morampudi, V., Dalwadi, U., Bhinder, G., Sham, HP., Gill, SK., Chan, J., Bergstrom, KSB., Huang, T., Ma, C., Jacobson, K., (2016) , The goblet cell-derived mediator RELM-beta drives spontaneous colitis in Muc2-deficient mice by promoting commensal microbial dysbiosis , Mucosal immunology, Nature Publishing Group,9,5,1218-1233.
10 Bergstrom, Kirk SB., Morampudi, Vijay., Chan, Justin M., Bhinder, Ganive., Lau, Jennifer., Yang, Hyungjun., Ma, Caixia., Huang, Tina., Ryz, Natasha., Sham, Ho Pan., (2015) , Goblet cell derived RELM-_ recruits CD4+ T cells during infectious colitis to promote protective intestinal epithelial cell proliferation , PLoS Pathog, Public Library of Science,11,8,e1005108.
9 Wu, Xiujuan., Conlin, Victoria S., Morampudi, Vijay., Ryz, Natasha R., Nasser, Yasmin., Bhinder, Ganive., Bergstrom, Kirk S., Hong, B Yu., Waterhouse, Chris CM., Buchan, Allison MJ., (2015) , Vasoactive intestinal polypeptide promotes intestinal barrier homeostasis and protection against colitis in mice , PloS one, Public Library of Science,10,5,e0125225.
8 Morampudi, Vijay., Conlin, Victoria Susan., Dalwadi, Udit., Wu, Xiujuan., Marshall, Kelsey C., Nguyen, Christine., Vallance, Bruce A., Jacobson, Kevan., (2015) , Vasoactive intestinal peptide prevents PKC_-induced intestinal epithelial barrier disruption during EPEC infection , American Journal of Physiology-Gastrointestinal and Liver Physiology, American Physiological Society Bethesda, MD,308,5,G389-G402.
7 Bhinder, Ganive., Stahl, Martin., Sham, Ho Pan., Crowley, Shauna M., Morampudi, Vijay., Dalwadi, Udit., Ma, Caixia., Jacobson, Kevan., Vallance, Bruce A., (2014) , Intestinal epithelium-specific MyD88 signaling impacts host susceptibility to infectious colitis by promoting protective goblet cell and antimicrobial responses , Infection and immunity, American Society for Microbiology Journals,82,9,3753-3763.
6 Morampudi, Vijay., Bhinder, Ganive., Wu, Xiujuan., Dai, Chuanbin., Sham, Ho Pan., Vallance, Bruce A., Jacobson, Kevan., (2014) , DNBS/TNBS colitis models: providing insights into inflammatory bowel disease and effects of dietary fat , JoVE (Journal of Visualized Experiments), ,,84,e51297.
5 Bhinder, Ganive., Sham, Ho Pan., Chan, Justin M., Morampudi, Vijay., Jacobson, Kevan., Vallance, Bruce A., (2013) , The Citrobacter rodentium mouse model: studying pathogen and host contributions to infectious colitis , JoVE (Journal of Visualized Experiments), ,,72,e50222.
4 Hekmatdoost, Azita., Wu, Xiujuan., Morampudi, Vijay., Innis, Sheila M., Jacobson, Kevan., (2013) , Dietary oils modify the host immune response and colonic tissue damage following Citrobacter rodentium infection in mice , American Journal of Physiology-Gastrointestinal and Liver Physiology, American Physiological Society Bethesda, MD,304,10,G917-G928.
3 Sham, Ho Pan., Yu, Emily Yi Shan., Gulen, Muhammet F., Bhinder, Ganive., Stahl, Martin., Chan, Justin M., Brewster, Lara., Morampudi, Vijay., Gibson, Deanna L., Hughes, Michael R., (2013) , SIGIRR, a negative regulator of TLR/IL-1R signalling promotes Microbiota dependent resistance to colonization by enteric bacterial pathogens , PLoS Pathog, Public Library of Science,9,8,e1003539.
2 Morampudi, Vijay., Braun, Michel Y., D\'Souza, Sushila., (2011) , Modulation of early _-defensin-2 production as a mechanism developed by Type I Toxoplasma gondii to evade human intestinal immunity , Infection and immunity, American Society for Microbiology Journals,79,5,2043-2050.
1 Morampudi, Vijay., De Craeye, Stephane., Le Moine, Alain., Detienne, Sophie., Braun, Michel Y., DSouza, Sushila., (2011) , Partial depletion of CD4+ CD25+ Foxp3+ T regulatory cells significantly increases morbidity during acute phase Toxoplasma gondii infection in resistant BALB/c mice , Microbes and infection, Elsevier,13,4,394-404.

 Although animal models contributed significantly to gastro-intestinal research, they do not completely elucidate the species-specific differences in the development of health or disease, and more importantly they do not mimic the human physiology and complexity. On the other hand, 2D cell-culture models do not fully recapitulate the physiology and function of living tissues. Recently, intestinal stem-cell derived 3D gut organoids having complex tissue structures and in-vivo like morphology offers many advantages to study host-microbial interactions, intestinal development and maturation,  cell-signalling pathways and epithelial barrier functions. Using human 3D gut organoids, my lab will be focussing on studying the following three projects- 

(1)    Studying the Protective Role of Lactobacilli Johnsonii against Enteropathogenic E. Coli Infection: Enteropathogenic E. Coli (EPEC) are among the most important pathogens that causes acute and sometimes persistent diarrhoea in children causing significant morbidity and mortality. By using human 3D organoids, we would like to investigate the protective effect of Lactobacilli johnsonii (L. johnsonii) during EPEC infection. This study will explore the colonization, growth and infection capabilities of EPEC in the presence or absence of L. johnsonii. Activation of NF-B pathway and its regulation of downstream signaling events including inflammatory cytokine production, anti-microbial responses and epithelial tight junction proteins will also be evaluated.  

(2)    Studying the Probiotic Effects of Breast Milk Lactobacilli on Intestinal Crypt Cell Development and Function: While it is apparent that human breast milk (HBM) microbiota can induce the development of intestinal immunity and homeostasis, it is unclear if these bacteria can contribute to the development of intestinal crypts. This project will explore the possible role of Lactobacilli strains that are found in HBM can play a role in epithelial cell proliferation, maturation and differentiation of intestinal crypts. This study will also explore the potential role of HBM Lactobacillus strains in protecting TNF-a induced epithelial barrier dysfunction. 

(3) Investigating the Complex Association of Cytokines that are implicated in Inflammatory Bowel Disease: Crohn’s disease (CD) and ulcerative colitis (UC) are the two forms inflammatory bowel disease (IBD) in humans that causes chronic inflammation in the gut. Inflammatory cytokines such as IL-1b, TNF-a, IFN-g, and cytokines of IL-23/Th17 pathway were shown to contribute in the pathogenesis of IBD while some recent reports suggested their protective role. To understand these conflicting results, cytokines should be tested in well-controlled conditions, the results of which can facilitate the development of effective therapies to treat IBD. By using human 3D organoids in controlled conditions, cytokines will be evaluated for the following parameters- expression of cell surface receptors that are implicated in IBD, defects in organoid cell development and maturation, and alterations in cellular and molecular signaling events.