Faculty Details

Faculty Details

  • Name: Prof. Krishnaveni Mishra
  • Mail: kmsluohyd.ernet.in
  • Contact:
  • Area Of Research:Nuclear architecture in gene regulation, genome organization and inter-organelle communication
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Students/Projects Trainees

Name Joined As Mail Contact
Gurranna Male PhD student guru3015@gmail.com ---
Pallavi Deolal PhD student pdeolal@gmail.com ---
Kathirvel R PhD Student r.kathir10@gmail.com ---
Chhaya Rani Kispotta PhD student chhayakispotta@gmail.com ---
Dipika Gupta PhD student dipikagupta592@gmail.com ---
Naresh Kumar M Post Doc mnareshkumarphd@hotmail.com ---
Renu Shukla Women Scientist drrenudshukla@gmail.com ---
Akash Gulyani Associate Professor akash.gulyani@gmail.com ---

Former Students/Projects Trainees

Name Joined As Working
Indukuri Srividya PhD student
Sirupangi Tirupataiah PhD Student
Nagesh Pasupala PhD student
Sreesankar Easwaran PhD student Postdoctoral Fellow, UCSB
Abdul Hannan PhD student Postdoctoral Research Fellow at Columbia University
Imlitoshi Jamir PhD student Assistant Professor, Nagaland University
Neethu Maria Abraham PhD student
Hita Sony Garapati PhD student
15 Hita Sony Garapati, Gurranna Male and Krishnaveni Mishra (2020) , Predicting subcellular localization of proteins using protein-protein interaction data , Genomics, Elsevier,,,, (3.327).
14 Neethu Maria Abraham, Kathirvel Ramalingam, Saketh Murthy, Krishnaveni Mishra (2019) , Siz2 Prevents Ribosomal DNA Recombination by Modulating Levels of Tof2 in Saccharomyces cerevisiae , mSphere, American Society of Microbiology,4,6,e00713, (4.447).
13 Neethu Maria Abraham, Krishnaveni Mishra (2018) , Elevated dosage of Ulp1 disrupts telomeric silencing in Saccharomyces cerevisiae , Molecular biology reports, Springer,45,,2481-2489.
12 Hita Sony Garapati, Krishnaveni Mishra (2018) , Comparative genomics of nuclear envelope proteins , BMC genomics, BioMed Central,19,,823.
11 Rahul Gujjula, Sangeetha Veeraiah, Kundan Kumar, Suman S Thakur, Krishnaveni Mishra, Rupinder Kaur (2016) , Identification of Components of the SUMOylation Machinery in Candida glabrata: ROLE OF THE DESUMOYLATION PEPTIDASE CgUlp2 IN VIRULENCE , The Journal of biological chemistry, American Society for Biochemistry and Molecular Biology,291,,19573-89.
10 Easwaran Sreesankar, Vellaichamy Bharathi, Rakesh K Mishra, Krishnaveni Mishra (2015) , Drosophila Rif1 is an essential gene and controls late developmental events by direct interaction with PP1-87B , Scientific reports, Nature Research,5,,10679.
9 Abdul Hannan, Neethu Maria Abraham, Siddharth Goyal, Imlitoshi Jamir, U Deva Priyakumar, Krishnaveni Mishra (2015) , Sumoylation of Sir2 differentially regulates transcriptional silencing in yeast , Nucleic acids research, Oxford University Press,43,,10213-26.
8 Sirupangi Tirupataiah, Imlitoshi Jamir, Indukuri Srividya, Krishnaveni Mishra (2014) , Yeast Nkp2 is required for accurate chromosome segregation and interacts with several components of the central kinetochore , Molecular biology reports, Springer,41,,787-97.
7 Rashmi U Pathak, Anitha Mamillapalli, Nandini Rangaraj, Ram P Kumar, Dasari Vasanthi, Krishnaveni Mishra, Rakesh K Mishra (2013) , AAGAG repeat RNA is an essential component of nuclear matrix in Drosophila , RNA biology, Landes Bioscience,10,,564-71.
6 Nagesh Pasupala, Sreesankar Easwaran, Abdul Hannan, David Shore, Krishnaveni Mishra (2012) , The SUMO E3 ligase Siz2 exerts a locus-dependent effect on gene silencing in Saccharomyces cerevisiae , Eukaryotic cell, American Society for Microbiology,11,,452-62.
5 Indukuri Srividya, Sirupangi Tirupataiah, Krishnaveni Mishra (2012) , Yeast transcription termination factor Rtt103 functions in DNA damage response , PloS one, Public Library of Science,7,,e31288.
4 Sreesankar, Easwaran, Senthilkumar Ramamoorthy, Bharathi Vellaichamy, Rakesh K Mishra, Krishnaveni Mishra (2012) , Functional diversification of yeast telomere associated protein, Rif1, in higher eukaryotes , BMC genomics, BioMed Central,13,,255.
3 Vivek Sarojkumar Chopra, Arumugam Srinivasan, Ram Parikshan Kumar, Krishnaveni Mishra, Denis Basquin, Mylene Docquier, Carole Seum, Daniel Pauli, Rakesh Kumar Mishra (2008) , Transcriptional activation by GAGA factor is through its direct interaction with dmTAF3 , Developmental biology, Elsevier,317,,660-70.
2 Rashmi U. Pathak, Nandini Rangaraj, Satish Kallappagoudar, Krishnaveni Mishra, Rakesh K. Mishra (2007) , Boundary element-associated factor 32B connects chromatin domains to the nuclear matrix , Molecular and cellular biology, American Society for Microbiology,27,,4796-806.
1 Krishnaveni Mishra, Vivek S. Chopra, Arumugam Srinivasan, Rakesh K. Mishra (2003) , Trl-GAGA directly interacts with lola like and both are part of the repressive complex of Polycomb group of genes , Mechanisms of Development, Elsevier,120,,681-9.

Our laboratory is interested in various aspects of nuclear cell biology. Our goal is to understand how the nucleus evolved, what regulates nuclear shape, how the nucleus interacts with other organelles and finally how all of this influences genome organization and function. Our primary model of choice is the budding yeast, Saccharomyces cerevisiae. We initiated a genetic screen in S. cerevisiae to unravel the molecular basis of compartmentalization within the nucleus and identified protein SUMOylation as a key regulator of inter-compartmental mobility for Sir2, a conserved NAD-dependent histone deacetylase. In a genome-wide screen for components that regulate nuclear shape, we have identified several key processes that influence nuclear shape and nuclear envelope organization. This includes the nucleolus, chromatin remodelers and components of the endoplasmic reticulum and vacuoles. In an effort to understand the origin of the nuclear envelope, we have taken a comparative genomics approach to identify components of the nuclear envelope that are conserved across supergroups. Interestingly, this study shows ancient origin for several components of the NE proteome. In other work we have identified a key role for transcription termination factor(s) in genome stability and are investigating how RNA metabolism affects genome organization and stability.