Faculty Details

Faculty Details

  • Name: Krishnaveni Mishra
  • Mail: kmsluohyd.ernet.in
  • Contact: 040 23134544
  • Area Of Research:Nuclear architecture in gene regulation, genome organization and inter-organelle communication

Krishnaveni Mishra obtained her Ph.D. from Centre for Cellular and Molecular Biology, Hyderabad in the year 1994 where she worked on transport of RNA and protein across the nuclear membrane in mammalian cells. She moved to Washington University, School of Medicine, St.Louis, Missouri, USA to pursue her post-doctoral studies in cell cycle regulation of nuclear pore complex protein expression in Saccharomyces cerevisiae. In 1996, she moved to the Department of Molecular Biology, University of Geneva, Geneva Switzerland where she focused on telomere length regulation and epigenetic gene regulation in S. cerevisiae. Returning to India in 2001, she joined CCMB as a postdoctoral fellow for a short while before accepting a Senior Research Associateship (CSIR-Pool officer) to pursue studies in nuclear architecture and epigenetics. In 2004, she joined the University of Hyderabad as a faculty at the Department of Biochemistry where she continues to study epigenetic gene regulation and nuclear architecture in gene expression and genome stability. She has extensive experience in yeast genetics, molecular biology and cell biology.

Krishnaveni Mishra was the Coordinator of Master’s in Systems Biology (5-year integrated) program at the School of Life Sciences from 2014 to 2018. She is also the Associate Director of the College for Integrated Studies (2014 onwards) where she coordinates the activities of the Integrated Master’s program in Sciences, Social Sciences and Humanities.

 

Awards/Achievements/Positions held

Ø  Professor, University of Hyderabad (2014 to date)

Ø  Associate Professor, University of Hyderabad. (2008- to 2014)

Ø  Lecturer, University of Hyderabad. (2004-08)

Ø  CSIR pool scientist at CCMB, Hyderabad.  (2003-04)

Ø  Post-doctoral fellow, CCMB, Hyderabad.  (2002-2003)

Ø  Post-doctoral fellowship, University of Geneva, Geneva, Switzerland (1996-2001)

Ø  Roche Post-doctoral Fellowship

Ø  Keck Foundation Fellowship


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Students/Projects Trainees

Name Joined As Mail Contact
Gurranna Male PhD student guru3015@gmail.com 914023134544
Pallavi Deolal PhD student pdeolal@gmail.com 914023134544
Kathirvel R PhD Student r.kathir10@gmail.com 914023134544
Chhaya Rani Kispotta PhD student chhayakispotta@gmail.com 914023134544
Dipika Gupta PhD student dipikagupta592@gmail.com 914023134544
Naresh Kumar Manda Post Doctoral Fellow (NPDF) mnareshkumarphd@hotmail.com 04023134544
Renu Shukla WOS-A Postdoctoral Fellow drrenudshukla@gmail.com 04023134544
Swati Singh Project JRF swatisatyendrasingh@gmail.com 04023134544

Former Students/Projects Trainees

Name Joined As Working
Neethu Maria Abraham PhD Student Associate Editor (Medicine), Cactus Communications
Imlitoshi Jamir PhD Student Assistant Professor, Central University of Nagaland
Sreesankar Easwaran PhD student Post-doctoral Fellow at University of California, Irvine, CA, USA
Abdul Hannan PhD student Post-doctoral Fellow, Columbia University Medical Center, NY, USA
Sirupangi Tirupataiah PhD student Post-doctoral Fellow, University of Louisiana
Hita Sony Gaarpati PhD student Post-doctoral Fellow, Excelra Knowledge Solutions Pvt. Ltd
Nagesh Pasupala PhD student Research Scientist at Uniformed Services University of the Health Sciecnes: Bethesda, MD, US
21 Garapati, Hita Sony., Male, Gurranna., Mishra, Krishnaveni., (2020) , Predicting subcellular localization of proteins using protein-protein interaction data , Genomics, Academic Press,112,3,2361-2368.
20 Abraham, Neethu Maria., Ramalingam, Kathirvel., Murthy, Saketh., Mishra, Krishnaveni., (2019) , Siz2 Prevents Ribosomal DNA Recombination by Modulating Levels of Tof2 in Saccharomyces cerevisiae , Msphere, American Society for Microbiology Journals,4,6,.
19 Abraham, Neethu Maria., Mishra, Krishnaveni., (2018) , Elevated dosage of Ulp1 disrupts telomeric silencing in Saccharomyces cerevisiae , Molecular biology reports, Springer Netherlands,45,6,2481-2489.
18 Garapati, Hita Sony., Mishra, Krishnaveni., (2018) , Comparative genomics of nuclear envelope proteins , BMC genomics, BioMed Central,19,1,823.
17 Gujjula, Rahul., Veeraiah, Sangeetha., Kumar, Kundan., Thakur, Suman S., Mishra, Krishnaveni., Kaur, Rupinder., (2016) , Identification of components of the sumoylation machinery in Candida glabrata role of the desumoylation peptidase CgUlp2 in virulence , Journal of Biological Chemistry, American Society for Biochemistry and Molecular Biology,291,37,19573-19589.
16 Sreesankar, Easwaran., Bharathi, Vellaichamy., Mishra, Rakesh K., Mishra, Krishnaveni., (2015) , Drosophila Rif1 is an essential gene and controls late developmental events by direct interaction with PP1-87B , Scientific reports, Nature Publishing Group,5,,10679.
15 Hannan, Abdul., Abraham, Neethu Maria., Goyal, Siddharth., Jamir, Imlitoshi., Priyakumar, U Deva., Mishra, Krishnaveni., (2015) , Sumoylation of Sir2 differentially regulates transcriptional silencing in yeast , Nucleic acids research, Oxford University Press,43,21,10213-10226.
14 Tirupataiah, Sirupangi., Jamir, Imlitoshi., Srividya, Indukuri., Mishra, Krishnaveni., (2014) , Yeast Nkp2 is required for accurate chromosome segregation and interacts with several components of the central kinetochore , Molecular biology reports, Springer Netherlands,41,2,787-797.
13 Pathak, Rashmi., Mamillapalli, Anitha., Rangaraj, Nandini., Kumar, Ram., Vasanthi, Dasari., Mishra, Krishnaveni., Mishra, Rakesh K., (2013) , AAGAG repeat RNA is an essential component of nuclear matrix in Drosophila , RNA biology, Taylor & Francis,10,4,564-571.
12 Srividya, Indukuri., Tirupataiah, Sirupangi., Mishra, Krishnaveni., (2012) , Yeast transcription termination factor Rtt103 functions in DNA damage response , Plos One, Public Library of Science,7,2,e31288.
11 Sreesankar, Easwaran., Senthilkumar, Ramamoorthy., Bharathi, Vellaichamy., Mishra, Rakesh K., Mishra, Krishnaveni., (2012) , Functional diversification of yeast telomere associated protein, Rif1, in higher eukaryotes , BMC genomics, BioMed Central,13,1,255.
10 Pasupala, Nagesh., Easwaran, Sreesankar., Hannan, Abdul., Shore, David., Mishra, Krishnaveni., (2012) , The SUMO E3 ligase Siz2 exerts a locus-dependent effect on gene silencing in Saccharomyces cerevisiae , Eukaryotic cell, American Society for Microbiology Journals,11,4,452-462.
9 Mishra, Krishnaveni., Mishra, Rakesh K., (2010) , Polycomb Group of Genes and the Epigenetics of Aging , Epigenetics of Aging, Springer, New York, NY,,,135-150.
8 Chopra, Vivek Sarojkumar., Srinivasan, Arumugam., Kumar, Ram Parikshan., Mishra, Krishnaveni., Basquin, Denis., Docquier, Mylène., Seum, Carole., Pauli, Daniel., Mishra, Rakesh Kumar., (2008) , Transcriptional activation by GAGA factor is through its direct interaction with dmTAF3 , Developmental biology, Elsevier,317,2,660-670.
7 Anitha, M., Kallappagoudar, Satish., Pathak, Rashmi U., Mishra, Krishnaveni., Rangaraj, Nandini., Jagannadham, MV., Sundaram, CS., Mishra, Rakesh K., (2008) , Characterization of Nuclear Matrix Proteome of Drosophila melanogaster During Embryonic Development , J Proteomics, ,2,,092-092.
6 Pathak, Rashmi U., Rangaraj, Nandini., Kallappagoudar, Satish., Mishra, Krishnaveni., Mishra, Rakesh K., (2007) , Boundary element-associated factor 32B connects chromatin domains to the nuclear matrix , Molecular and cellular biology, American Society for Microbiology Journals,27,13,4796-4806.
5 Mishra, Krishnaveni., Chopra, Vivek S., Srinivasan, Arumugam., Mishra, Rakesh K., (2003) , Trl-GAGA directly interacts with lola like and both are part of the repressive complex of Polycomb group of genes , Mechanisms of development, Elsevier,120,6,681-689.
4 Mishra, Krishnaveni., Shore, David., (1999) , Yeast Ku protein plays a direct role in telomeric silencing and counteracts inhibition by rif proteins , Current biology, Cell Press,9,19,1123-S2.
3 Mishra, Krishnaveni., Parnaik, Veena K., (1995) , Essential role of protein phosphorylation in nuclear transport , Experimental cell research, Academic Press,216,1,124-134.
2 Pandey, Siyaram., Karande, Anjali A., Mishra, Krishnaveni., Parnaik, Veena K., (1994) , Inhibition of nuclear protein import by a monoclonal antibody against a novel class of nuclear pore proteins , Experimental cell research, Academic Press,212,2,243-254.
1 Mishra, Krishnaveni., Divi, Kathyayini., Parnaik, Veena K., (1994) , A conserved epitope on nuclear pore phosphoproteins reflects cell division status. , Indian journal of biochemistry & biophysics, ,31,4,243-248.
Title Year Duration Amount(In Lakhs) PI/I
Identification of the SUMOylation target in yeast heterochromatin 2019 3 20 Krishnaveni Mishra
Role of SUMOylation in virulence of Candida glabrata 2018 3 48.028 Krishnaveni Mishra
Centre of Excellence in Biomolecular Structure and Function on Host Pathogen Interactions 2016 5 69.8 Krishnaveni Mishra

Our laboratory is interested in various aspects of nuclear cell biology. Our goal is to understand how the nucleus evolved, what regulates nuclear shape, how the nucleus interacts with other organelles and finally how all of this influences genome organization and function. Our primary model of choice is the budding yeast, Saccharomyces cerevisiae. We initiated a genetic screen in S. cerevisiae to unravel the molecular basis of compartmentalization within the nucleus and identified protein SUMOylation as a key regulator of inter-compartmental mobility for Sir2, a conserved NAD-dependent histone deacetylase. In a genome-wide screen for components that regulate nuclear shape, we have identified several key processes that influence nuclear shape and nuclear envelope organization. This includes the nucleolus, chromatin remodelers and components of the endoplasmic reticulum and vacuoles. In an effort to understand the origin of the nuclear envelope, we have taken a comparative genomics approach to identify components of the nuclear envelope that are conserved across supergroups. Interestingly, this study shows ancient origin for several components of the NE proteome. In other work, we have identified a key role for transcription termination factor(s) in genome stability and are investigating how RNA metabolism affects genome organization and stability.