Faculty Details

Faculty Details

  • Name: Prof. Sharmistha Banerjee
  • Mail: sbsluohyd.ac.in
  • Contact:
  • Area Of Research:Molecular pathogenesis and immunology of Mycobacterium tuberculosis (M.tb), Human Immunodeficiency Virus (HIV) and M.tb-HIV co-infection.

Brief Profile

 Sharmistha Banerjee received her Ph.D. in Biochemistry in 2005 from University of Hyderabad. She worked at Centre for DNA Fingerprinting and Diagnostics, Hyderabad, India, and later continued her postdoctoral studies at the Laboratory of Transcriptional Biology on mechanisms of Rho-dependent termination in E.coli. She worked briefly at Molecular Cardiology Unit, Lerner Research Institute, The Cleveland Clinic, Cleveland, USA on role of integrins in prostate cancer metastasis.

Presently, as a Professor in the Department of Biochemistry, School of Life Sciences, she teaches Immunology and Enzymology along with various topics on Infectious diseases and host pathogen interactions.

 

Research Interests

 The Research focus of her laboratory is molecular pathogenesis and immunology of Mycobacterium tuberculosis(M.tb), Human Immunodeficiency Virus (HIV) and M.tb-HIV co-infection.

 

The laboratory is working on two human pathogens, Mycobacterium tuberculosis [tuberculosis (TB) causing bacteria] and Human Immunodeficiency Virus (HIV), the synergistic pandemic of which is a major health concern in India and worldwide. The laboratory, in the last few years, has added important baseline information on molecular mechanisms behind pathogenesis of HIV and mycobacteria, during both mono-and co-infection, identifying potential drug targets and biomarkers. Presently, the following themes are under investigation:

 

(a) Cellular and Molecular Mechanisms of Mycobacterial physiology: Deciphering adaptive metabolic and regulatory networks of Mycobacterium tuberculosis in response to infection and related stresses through proteomics and metabolomics; identification and validation of critical enzymes as potential targets and screening small molecule inhibitors against these targets for anti-mycobacterial activity.

 (b) Molecular insights into HIV Biology: Investigating perturbations in nuclear architecture during HIV-1 infection and studying the molecular basis of differential regulation of viral persistence and propagation in diverse cell types.

(c) Molecular Mechanismsof M.tb-HIV co-infection: System-wide studies to identify the concurrent perturbations in the proteomes of both host cell and intracellular mycobacteria during HIV co-infection and deciphering the underlying molecular mechanisms.

 

Honours and Awards:

           Chancellor’s Award 2017, University of Hyderabad

           National Women Bioscientist Award (Young Category) 2016, from Department of Biotechnology, Govt. of India

           Prof BK Bachhawat International Travel Grant for Young Scientists 2018

           Innovative Young Biotechnologist Award (IYBA) 2011, from the Department of Biotechnology, Govt. of India

           BioAsia Innovation Award 2008

           INSA Young Scientist Award 2005, from the Indian National Science Academy.

 

No Records Available

Students/Projects Trainees

Name Joined As Mail Contact
Dr. Krishnaveni Mohareer WOS A Scientist krishnaveni.mohareer@gmail.com ---
Kumaraswami Chintala PhD scholar swamy.chintala9@gmail.com ---
Jaya Shankar PhD scholar shankar.medikonda@gmail.com ---
Kannan BalaKrishnan PhD Scholar bkannan7690@gmail.com ---
Kiran Jakkala PhD scholar jkiranau@gmail.com ---
Govinda Raju Vadankula PhD scholar govindraj.vadankula@gmail.com ---
Sriram Yendrapelly PhD Scholar sriramyendrapelly@gmail.com ---
Mahesh Gauraram Lab manager gouraram2@gmail.com ---
Manasa N Project student nmanasa97@gmail.com ---
Akrati Bhatt Project Student nehabhat045@gmail.com ---
Harish Kumar Dubey Project JRF harishkd1989@gmail.com ---
Geetika Arekuti Technical assistant geethikaarekuti@gmail.com ---

Former Students/Projects Trainees

Name Joined As Working
Ronald Benzamin PhD scholar
Atoshi Banerjee PhD scholar
Rakesh Ganji PhD scholar
Harika Vemula Mani PhD scholar
Iqra Bashir Nehvi PhD scholar
Suman Asalla PhD scholar
Arshad Rizvi PhD scholar
Swetha Sankati Project assistant
Lavanya Priyadarshini Project JRF
41 Rizvi A, Shankar A, Chatterjee A, More TH, Bose T, Dutta A, Balakrishnan K, Madugulla L, Rapole S, Mande SS*, Banerjee S*, Mande SC*. (2019) , Rewiring of Metabolic Network in Mycobacterium tuberculosis During Adaptation to Different Stresses. , Front Microbiol. , Frontiers,10,2417,.
40 Rizvi A, Yousf S, Balakrishnan K, Dubey HK, Mande SC, Chugh J, Banerjee S . (2019) , Metabolomics studies to decipher stress responses in Mycobacterium smegmatis point to a putative pathway of methylated amines biosynthesis. , Jbact., ASM,201,15,707-718.
39 Kumar A, Phulera S, Rizvi A, Sonawane PJ, Panwar HS, Banerjee S, Sahu A, Mande SC. (2019) , Structural basis of hypoxic gene regulation by the Rv0081 transcription factor of Mycobacterium tuberculosis. , FEBS Letters, Wiley,593,,982-995.
38 Mohareer K, Asalla S, Banerjee S (2018) , Cell death at the cross roads of host-pathogen interaction in Mycobacterium tuberculosis infection , Tuberculosis (Edinb), Elsevier,113,,99-121.
37 Khadkikar P, Goud NS, Mohammed A, Ramamoorthy G, Ananthathatmula R, Doble M, Rizvi A, Banerjee S, Ravi A, Alvala (2018) , An efficient and facile green synthesis of bisindole methanes as potential Mtb FtsZ inhibitors. , Chem Biol Drug Des. , Wiley,92,,1933-1939.
36 Divya MB, Vemula M, Balakrishnan K, Banerjee S, Guruprasad L. (2018) , Mycobacterium tuberculosis PE1 and PE2 proteins carrying conserved a/b-serine hydrolase domain are esterases hydrolyzing short to medium chain p-nitrophenyl esters. , Prog Biophys Mol Biol., ,,,.
35 Asalla S, Mohareer K, Banerjee S. (2017) , Small molecule mediated restoration of mitochondrial function augments anti-mycobacterial activity of human macrophages subjected to cholesterol induced asymptomatic dyslipidemia. , Front. Cell. Infect. Microbiol. , Frontiers,,,.
34 Balakrishnan K, Mohareer K, Banerjee S. (2017) , Mycobacterium tuberculosis Rv1474c is a TetR-like transcriptional repressor that regulates aconitase, an essential enzyme and RNA-binding protein, in an iron-responsive manner. , Tuberculosis (Edinb.), Elsevier,103,,71–82.
33 Dev RR, Ganji R, Singh SP, Mahalingam S, Banerjee S, Khosla S. (2017) , Cytosine methylation by DNMT2 facilitates stability and survival of HIV-1 RNA in the host cell during infection , Biochem J, Portland Press,,,.
32 Reddy ER, Yaseen AM, Rizvi A, Deora GS, Banerjee S, Sevilimedu A, Rajadurai M. (2017) , Antibacterial Nanoparticles Based on Fluorescent 3-Substituted Uridine Analogue , Chemistry Select , Wiley,2,,557-561.
31 Vemula MH, Medisetti R, Ganji R, Jakkala K, Sankati S, Chatti K, Banerjee S. (2016) , Mycobacterium tuberculosis Zinc Metalloprotease-1 assists mycobacterial dissemination in Zebrafish. , Front Microbiol. , Frontiers,,,.
30 Vemula MH, Ganji R, Sivangala R, Jakkala K, Gaddam S, Penmetsa S, Banerjee S. (2016) , Mycobacterium tuberculosis Zinc Metalloprotease-1 Elicits Tuberculosis-Specific Humoral Immune Response Independent of Mycobacterial Load in Pulmonary and Extra-Pulmonary Tuberculosis Patients , Front Microbiol. , Frontiers,,,.
29 Ganji R, Dhali S, Rizvi A, Rapole S, Banerjee S. (2016) , Understanding HIV-Mycobacteria synergism through comparative proteomics of intra-phagosomal mycobacteria during mono- and HIV co-infection. , Scientific Reports , Nature,,,.
28 Sharma G, Sowpati DT, Singh P, Khan MZ, Ganji R, Upadhyay S, Banerjee S, Nandicoori VK, Khosla S. (2016) , Genome-wide non-CpG methylation of the host genome during M. tuberculosis infection , Scientific reports, Nature,,,.
27 Ganji R, Dhali S, Rizvi A, Sankati S, Vemula MH, Mahajan G, Rapole S, Banerjee S. (2016) , Proteomics approach to understand reduced clearance of mycobacteria and high viral titers during HIV-mycobacteria co-infection , Cellular Microbiology, Wiley,18,,355-368..
26 Sharma A, Rustag T, Mahajan G, Kumar A, Rao Kanury V. S, Banerjee S, Sherman DR and Mande SC (2016) , Towards understanding the biological function of the unusual chaperonin GroEL1 of Mycobacterium tuberculosis. , Tuberculosis (Edinb). , Elsevier,97,,137-146.
25 Ramaprasad EVV, Rizvi A, Banerjee S, Sasikala Ch, Ramana Ch.V. (2016) , Mycobacterium oryzae sp. nov., a scotochromogenic, rapidly growing species is able to infect human macrophage cell line. , Int J Syst Evol Microbiol, Microbiology Society,66,,4530-4536.
24 Banerjee A, Benjamin R, Balakrishnan K, Ghosh P and Banerjee S (2014) , Human protein Staufen-2 promotes HIV-1 proliferation by positively regulating RNA export activity of viral protein Rev. Human protein Staufen-2 promotes HIV-1 proliferation by positively regulating RNA export activity of viral protein Rev. , Retrovirology, Springer,11,,18.
23 Benjamin R, Banerjee A, Balakrishnan K, Sivangala R, Gaddam S, Banerjee S. (2014) , Mycobacterial and HIV Infections Up-Regulated Human Zinc Finger Protein 134, a Novel Positive Regulator of HIV-1 LTR Activity and Viral Propagation. , Plos One, Public Library of Science,9,8,e104908.
22 Suragani M, Aadinarayana VD, Pinjari AB, Tanneeru K, Guruprasad L, Banerjee S, Pandey S, Chaudhuri TK, Ehtesham NZ (2013) , Human resistin, a proinflammatory cytokine, shows chaperone-like activity. , Proc. Natl. Acad. Sci. USA. , National Academy of Sciences,110,51, 20467–20472.
21 Banerjee A, Benjamin R, Banerjee S. (2013) , Impact of viral factors on subcellular distribution and RNA export activity of HIV-1 rev in astrocytes 1321N1 , PLoS One, Public library of Science,,,.
20 Sultana R, Vemula MH, Banerjee S, Guruprasad L. (2013) , The PE16 (Rv1430) of Mycobacterium tuberculosis Is an Esterase Belonging to Serine Hydrolase Superfamily of Proteins. , PLoS ONE , Public library of Science,,,.
19 Mohareer K, Banerjee S and Hasnain SE. (2013) , Recombinant DNA technology in Eukaryotic gene expression system. , Textbook of Biochemistry, Biotechnology, Allied , Prentice Hall of India,,,.
18 Benjamin R, Banerjee A, Sunder SR, Gaddam S, Valluri VL and Banerjee S. (2013) , Discordance in CD4 T-Cell Levels and Viral Loads with Co-Occurrence of Elevated Peripheral TNF-a and IL-4 in Newly Diagnosed HIV-TB Co-Infected Cases. , PLoS One, ,,,.
17 Ramachary DB, Reddy YV, Atoshi Banerjee A and Banerjee S. (2011) , Design, synthesis and biological evaluation of optically pure functionalized spiro[5,5]undecane-1,5,9-triones as HIV-1 inhibitors. , Org. Biomol. Chem. , ,9,,7282-7286 .
16 Banerjee S, Farhana A, Ehtesham NZ, Hasnain SE. (2011) , Iron acquisition, assimilation and regulation in mycobacteria. , Infection, Genetics and Evolution , ,11,,825–838.
15 Hasnain SE, Banerjee S, Ehtesham NZ . (2011) , Translating advances in genomic research into clinical practice: The challenges ahead. , Med Princ. Pract., ,20,,392-394.
14 Banerjee S, Mohareer K, Hasnain SE. (2010) , Tuberculosis Related Immune Complications: A New Dilemma in Disease Management; in Biotechnology for sustainable development: achievements and challenges. , Biotechnology for sustainable development: achievements and challenges., ,,,143-151.
13 Banerjee S, Mohareer K, Hasnain SE. (2010) , Molecular diagnostics of MDR and XDR TB. , Ranbaxy Science Foundations, ,,,73-87.
12 Banerjee S, Siddiqi N, Hasnain SE . (2009) , Drug resistance tuberculosis. , Tuberculosis, Edited by Sharma SK and Alladi Mohan,,,.
11 Banerjee S, Nandyala A K, Podili R, Ahmed N and Hasnain SE. (2007) , Iron dependent RNA-binding activity of Mycobacterium tuberculosis aconitase. , J Bacteriol, ,189,,4046-4052..
10 Chalissery J, Banerjee S, Bandey I and Sen R . (2007) , Transcription termination defective mutants of Rho: role of different functions of Rho in releasing RNA from the elongation complex. , . J Mol Biol. , ,371,,855-872.
9 Pani B, Banerjee S, Chalissery J, Abhishek M, Malarini L R, Suganthan R, Sen R . (2006) , Mechanism of inhibition of Rho-dependent transcription termination by bacteriophage P4 protein PSU. , J Biol Chem , ,281,36,26491-500.
8 Banerjee S, Chalissery J, Bandey I and Sen R. (2006) , Rho-dependent transcription termination: more questions than answers. , J Microbiol. , ,44,,11-22.
7 Banerjee S, Nandyala A, Podili R, Katoch VM and Hasnain SE. (2005) , Comparison of Mycobacterium tuberculosis isocitrate dehydrogenases (ICD-1 and ICD-2) reveals differences in coenzyme affinity, oligomeric state, pH tolerance and phylogenetic affiliation. , BMC Biochemistry, ,29,,6-20.
6 Sah NK, Singh SN, Sahdev S, Banerjee S, Jha V, Khan Z, Hasnain SE. (2005) , Indian herb ‘Sanjeevani’ (Selaginella bryopteris) can promote growth and protect against heat shock and apoptotic activities of ultra violet and oxidative stress. , J Biosci., ,30,,499-505.
5 Banerjee S, Nandyala A, Podili R, Katoch VM, Murthy KJR and Hasnain SE. (2004) , Mycobacterium tuberculosis (M. tb) isocitrate dehydrogenases show strong B cell response and distinguish vaccinated controls from TB patients. , Proc. Natl. Acad. Sci. USA. , ,101,,12652- 12657. .
4 Siddiqi N, Das R, Pathak N, Banerjee S, Ahmed N, Katoch VM and Hasnain SE (2004) , Mycobacterium tuberculosis isolate with a distinct genomic identity overexpresses a TAP like efflux pump. , Infection. , ,32,,93-95 .
3 Ghosh S, Rasheedi S, Rahim SS, Banerjee S, Choudhary RK, Chakhaiyar P, Ehtesham NZ, Mukhopadhyay S, Hasnain, SE. (2004) , A novel method for enhancing solubility of the expressed proteins in E. coli. , Biotechniques, ,37,,418-424.
2 Siddiqi N, Shamim M, Hussain S, Choudhary RK, Ahmed N, Prachee, Banerjee S, Savithri GR, Alam M, Pathak N, Amin A, Hanief M, Katoch VM, Sharma SK and Hasnain SE. (2002) , Molecular Characterization of Multi-Drug Resistant Isolates of Mycobacterium tuberculosis From Patients in North-India. , Antimicrob. Agents Chemother., ,46,,443-450.
1 Ahmed N, Bal A, Khan AA, Alam M, Kagal A, Arjunwadkar V, Rajput A, Majeed AA, Rahman SA, Banerjee S, Joshi S, Bharadwaj R. (2002) , Whole genome fingperprinting and genotyping of multiple drug resistant (MDR) isolates of Pseudomonas aeruginosa from endophthalmitis patients in India. , Infection, Genetics and Evolution. , ,1,,1-6.
Title Year Duration Amount(In Lakhs) PI/I
Design and Development of novel antitubercular agents targeting Shikimate kinase protein” under DBT (No. BT/PR23619/MED/29/1199/2017, dated 09.01.2018) 2018 3 years 21.6 Prof. Sharmistha Banerjee
Identification and Characterization of mycobacterial factors supporting HIV propagation during HIV-mycobacteria co-infection (BT/HRD/NWBA/38/09/2018) 2018 5 years 25 Prof. Sharmistha Banerjee
Assessment of antimicrobial and plant growth promoting potential of indigenous endophytic bacterial strains of Manipur” under DBT’s Twinning Programme for NER (No. BT/PR25395/NER/95/1177/2017) 2018 3 years 15.3 Prof. Sharmistha Banerjee
Centre of Excellence in Biomolecular structure and function on Host-Pathogen interaction (BT/PR15450/COE/34/46/2016) 2016 5 years 76.11 Prof. Sharmistha Banerjee

Sl No.

Title of Project

Funding Agency

Amount (In Lakhs)

Date of Sanction and completion

Duration

1.

“Identification and Characterization of mycobacterial factors supporting HIV propagation during HIV-mycobacteria co-infection (BT/HRD/NWBA/38/09/2018)”

DBT, Govt. of India

25.00 lakhs

18.07.2018 to

17.07.23

5 years

(ongoing)

2.

‘Assessment of antimicrobial and plant growth promoting potential of indigenous endophytic bacterial strains of Manipur” under DBT’s Twinning Programme for NER (No. BT/PR25395/NER/95/1177/2017, dated 11.09.2018)

DBT, Govt. of India

15.36992 lakhs

01.09.2018 to

31.08.2021

3 years (ongoing)

3.

‘Design and Development of novel antitubercular agents targeting Shikimate kinase protein” under DBT (No. BT/PR23619/MED/29/1199/2017, dated 09.01.2018)

DBT, Govt. of India

21.6 lakhs

09.01.2018 to

08.01.2021

3 years (ongoing)

4

Centre of Excellence in Biomolecular structure and  function on Host-Pathogen interaction (BT/PR15450/COE/34/46/2016)

DBT, Govt. of India

76.11 lakhs

28.12.16 to 27.12.21

5 years (ongoing)

5

Identification and functional characterization of proteins from Mycobacterium tuberculosis targeting host-cell mitochondria and studying their role in pathogenesis (EMR/2015/001029)

DST

46.56 lakhs

25.05.16 to 24.05.19

 

 

3 years + 6 months no cost extension

 

6

Understanding the role of Rev-Staufen interactions in regulating HIV-1 propagation by altering cytoplasmic mRNA-silencing foci and nuclear membrane architecture (BT/PR12626/MED/29/915/2014)

DBT

50.105 lakhs

18.07.16 to 17.07.19

3 years

7

SysTB: A network program for resolving the intracellular dynamics of host pathogen interaction in TB infection (BT/PR3260/BRB/10/967/2011) PI

DBT, Govt. of India

80.79 lakhs

09.01.12 till 08.01.17

5 years

8

Identification and chracterization of new iron-dependent post-transcriptional regulome of Mycobacteria (BT/05/IYBA/2011) PI

DBT, Govt. of India

54.18 lakhs

28.03.12 to 27.11.2017

Duration was 3 years followed by 4th and 5th  year merit based extension with funds

9

TBomics: An omics approach for diagnosing tuberculosis (New-Indigo-II)(BT/IN New Indigo/05/SB/2013) PI

DBT, Govt. of India

International Collaboration

55.95 lakhs

 

02.07.13 to 31.12.16

3 years + 6 months no cost extension

10

DBT Twin: Discovery of the bioactive natural products from microbes especially Actinimycetes in niche biotopes in Manipur (BT/47/NE/TBP/2010) PI

DBT, Govt. of India

15.30 lakhs

 

 

15.03.11 to 14.03.14

3 years

11

DBT-Centre of Excellence-Identification of new therapeutic targets and immune activation markers in M. tb co-infections using comparative proteomics BT/01/COE/07/02 PI

DBT, Govt. of India

61.25 lakhs

 

30.12.08 to 30.06.14

5 years + 6 months no cost extension

12

Physiological role of Rev in the cytoplasm of infected host cells: interactions with cytoplasmic host factors and association with viral pre-integration complex (PIC) BT/PR10092/BRB/10/585/2007 (letter II) PI

DBT, Govt. of India

21.80 lakhs

01.06.09 to 30.11.12

3 years + 6 months no cost extension

13

Study of inflammatory cytokine profiles in Mycobacterium tuberculosis – HIV co-infected patients (BT/PR10303/GBD/27/74/2007) PI

DBT, Govt. of India

24.44 lakhs

From 11-01-08 to10-01-11

3 years

14

Physiological role of Mycobacterium tuberculosis aconitase in iron regulation BS/YSP/57/2007/182 PI

INSA

1.5 lakhs

From 01-01-08 to 31.12.11

3 years