Faculty Details

Faculty Details

  • Name: Dr. Radheshyam Maurya
  • Mail: rmusluohyd.ernet.in
  • Contact: 04023134532
  • Area Of Research:Host Pathogen Interaction, Mechanism of Drug Resistance and Drug Discovery

Visceral leishmaniasis (VL) is a life-threatening disease characterized by uncontrolled parasitization in the spleen, liver, and bone marrow of the host. We have first demonstrated that natural CD4+CD25+ (Foxp3high) T reg cells in human VL did not accumulate in the spleen and were not a major source of IL-10. We also first time demonstrated that leptin deficiency during Leishmania infection as a result of malnutrition impaired the T cell-mediated immunity and indices the host protective Th1 type cytokine response in macrophages suggesting its immunomodulatory role. Leptin treatment protects L. donovani infection through the classical macrophage activity and induces a T-cell mediated immune response in malnutrition coupled VL. We also identified the anti-leishmanial and immunomodulatory activities of Withania somnifera leaf extract, Withaferin-A and Neem leaf extract in both in-vitro and in-vivo model of VL. The studies reveal that phytochemicals have a potential scope with minimal side effects compared to the conventional treatment regime. Very recently, we also identified the Miltefosine resistance gene in the Leishmania parasite. We are trying to understand the mechanism of Infection and Immunity in VL, drug-resistant mechanism, identification of the new drug, and diagnostic markers. 

No Records Available

Students/Projects Trainees

Name Joined As Mail Contact
Moodu Devender Research Scholar devendernayak369@gmail.com ---
Madhulika Namdeo Research Scholar madhulikanamdeo92@gmail.com ---
Prince Sebastian Research Scholar princecell1@gmail.com ---
KRISHAN KUMAR Research Scholar krishanandc2013@gmail.com ---
Anjali Anand Research Scholar anjalianand763@gmail.com ---

Former Students/Projects Trainees

Name Joined As Working
Dr. S. Chandrasekaran Research Scholar http://koshylab.arizona.edu
Dr. Jalaja Veronica Research Scholar
Dr. Dayakar Alti Research Scholar
Dr. Bharadwaja Vadloori Research Scholar Bio-Nest, SLS, UoH
17 J. Veronica, S. Chandrasekaran1, A. Dayakar, M. Devender, V. K. Prajapati, S. Sundar and R. Maurya* (2019) , Iron superoxide dismutase contributes to miltefosine resistance in Leishmania donovani , The FEBS Journal, Federation of European Biochemical Societies,286,,3488–3503 IF - 4.5.
16 Bharadwaja Vadloori, A. K. Sharath, N. Prakash Prabhu, Radheshyam Maurya* (2018) , Homology modelling, molecular docking, and molecular dynamics simulations reveal the inhibition of Leishmania donovani dihydrofolate reductase-thymidylate synthase enzyme by Withaferin-A , BMC Research Notes, BMC Group,11,246,1-7 IF - 1.6.
15 R Maurya*, P. Bhattacharya, R. Dey and H. L. Nakhasi (2018) , Leptin Functions in Infectious Diseases , Frontiers in Immunology, Frontiers,11,2741,1-16 IF - 5.5.
14 Chandrasekaran S, Veronica J, Sundar S, Maurya R* (2017) , Alcoholic fractions F5 and F6 from W somnifera leaves shown a potent antileishmanial and immunomodulatory activities to control experimental visceral leishmaniasis , Frontiers in Medicine, Frontiers,4,55,1-13 IF - 3.5.
13 Alti Dayakar, Sambamurthy Chandrasekaran, Jalaja Veronica, Vadloori Bharadwaja, Radheshyam Maurya* (2017) , Leptin regulates Granzyme-A, PD-1 and CTLA-4 expression in T cell to control visceral leishmaniasis in BALB/c Mice , Scientific Report, Nature Publishing Group,7,1,14664 IF - 4.5.
12 Radheshyam Maurya* (2017) , Withanolides: A prospective Drug for Infectious and Tropical Diseases , Science of Ashwagandha: Preventive and Therapeutic Potentials. S.C. Kaul, R. Wadhwa (eds.) , Springer International Publishing AG ,,,105-120.
11 Chandrasekaran S, Jalaja Veronica, Gundampati RK, Shyam Sundar, Radheshyam Maurya* (2016) , Exploring the inhibitory activity of Withaferin-A against Pteridine reductase-1 of L. donovani , J Enzyme Inhib Med Chem, Taylor ,31,6,1029–1037 IF - 4.1.
10 Dayakar A, Chandrasekaran S, Veronica J, Maurya R* (2016) , Leptin induces the phagocytosis and protective immune response in Leishmania donovani infected THP-1 cell line and human PBMCs , Experimental Parasitology, Elsevier,160,,54-59 IF - 1.8.
9 Radheshyam. Maurya*, P Bhattacharya, Nevien Ismail, P K. Dagur, A B. Joshi, K Razdan, J. P McCoy Jr. A Jill, R. Dey,* and H. L. Nakhasi (2016) , Differential Role of Leptin as an Immunomodulator in Controlling Visceral Leishmaniasis in Normal and Leptin-Deficient Mice , Am J Trop Med Hyg, American Society of Tropical Medicine and Hygiene,95,1,109-119 IF - 2.8.
8 Suresh K. Kalangi, A. Dayakar, D. Gangappa, R. Sathyavathi, R.S. Maurya*, D. Narayana Rao* (2016) , Biocompatible silver nanoparticles reduced from Anethum graveolens leaf extract augments the antileishmanial efficacy of miltefosine , Experimental Parasitology, Elsevier,170,,184-192 IF - 1.8.
7 Dayakar A, Chandrasekaran S, Jalaja Veronica, Shyam Sundar, Radheshyam Maurya* (2015) , In vitro and in vivo evaluation of anti-Leishmanial and immunomodulatory activity of Neem leaf extract in Leishmania donovani infection. , Experimental Parasitology, Elsevier,153,,45–54 IF - 1.8.
6 Sambamurthy Chandrasekaran, Alti Dayakar, Jalaja Veronica, Shyam Sundar, Radheshyam Maurya* (2013) , An in vitro study of apoptotic like death in Leishmania donovani promastigotes by Withanolides. , Parasitology International., Elsevier,62,3,253–261 IF - 2.1.
5 Dayakar, S. Chandrasekaran, J. Veronica, and R. Maurya* (2011) , Role of leptin in human visceral leishmaniasis? , Medical Hypotheses, Elsevier Wiley,77,,416–418 IF - 1.4.
4 Shalini Gautam*, Rajiv Kumar*, Radheshyam Maurya*, Susanne Nylén, Nasim Ansari, Madhukar Rai, Shyam Sundar, and David Sacks (2011) , IL-10 Neutralization promotes parasites clearance in splenic aspirate cells from patients with visceral leishmaniasis. , Journal of Infectious Disease, Oxford Academic Press,204,7,1134-1137 IF - 5.2.
3 Alti Dayakar, Sambamurthy Chandrasekaran, Vijay kumar Prajapati, Jalaja Veronica, Shyam Sundar, Radheshyam Maurya*. (2011) , A rapid method to assess the stage differentiation in Leishmania donovani by flow cytometry , Experimental Parasitology , Elsevier,132,,495–500 IF - 1.8.
2 Maurya R; Kumar R; Prajapati V K; Manandhar K D; Sacks D; Sundar S; Nylén S. (2010) , Human visceral leishmaniasis is not associated with expansion or accumulation of Foxp3 CD4 cells in blood or spleen. , Parasite Immunology , Elsevier Wiley,32,7,479-83 IF - 2.5.
1 Maurya Radheshyam; Mehrotra Sanjana; Prajapati Vijay Kumar; Nylén Susanne; Sacks David; Sundar Shyam (2010) , Evaluation of blood agar microtiter plates for culturing leishmania parasites to titrate parasite burden in spleen and peripheral blood of patients with visceral leishmaniasis , Journal of Clinical Microbiology, American Society of Microbiology,48,5,1932-4 IF - 4.1.