is an Assistant Professor in the Department of Animal Biology at the University of Hyderabad (UoH). During his PhD, at University of Hyderabad, Dr. Tammineni was supported by CSIR fellowship to understand the mechanistic details of STAT3 transport to mitochondria and its non-canonical functions in redox homeostasis. He then moved to Rutgers University (USA) to conduct postdoctoral research on endo-lysosomal trafficking and autophagy regulation in Alzheimer's Disease, using transgenic mouse models and state-of-the art imaging modules. Dr. Tammineni then moved to MIT (USA), as a Picower Research Fellow, to investigate the mechanisms of synaptic plasticity in neurodevelopmental and neuropsychiatric disorders. Dr. Tammineni now runs a Molecular Neurosciences lab at UoH. Overarching goal of his research group is to understand the molecular mechanisms of membrane trafficking and how organelle/protein quality control is regulated in neuronal health and disease.
|Janakiramulu Pasula||Project Assistantfirstname.lastname@example.org||7661011845|
|Preethi Kandagiri||MSc Thesis Projectemail@example.com||---|
|Rajyalaxmi||MSc thesis Projectfirstname.lastname@example.org||---|
|Anusruti Sabui||Graduate Student||---||---|
|Mitali Biswas||Graduate Student||---||---|
Former Students/Projects Trainees
|Kashmiri Manishrao Lande||Winter Internship Student||Kashmiri is our own student pursuing towards Master's degree in Animal Biology. She finished her B.Sc. (Zoology) from Fergusson College, Pune before joining UoH.|
|17||Rajkishor Nishad, Dhanunjay Mukhi, Ashish Kumar Singh, Manga Motrapu, Kumaraswami Chintala, Prasad Tammineni, and Anil K. Pasupulati (2021) , Growth hormone induces mitotic catastrophe of glomerular podocytes and contributes to proteinuria , Cell Death and Disease, ,10.1038/s41419-021-03643-6,,.|
|16||Mohammed F, Gorla M, Bisoyi V, Tammineni P, Sepuri NBV (2020) , Rotenone-induced reactive oxygen species signal the recruitment of STAT3 to mitochondria , FEBS Letters, FEBS Press,doi: 10.1002/1873-3468.13741,,.|
|15||Rathje M, Waxman H, Benoit M, Tammineni P, Leu C, Loebrich S, Nedivi E (2019) , Genetic variants in the bipolar disorder risk locus SYNE1 that affect CPG2 expression and protein function , Mol. Psychiatry, Nature Publishing Group,doi: 10.1038/s41380-018-0314-z,,.|
|14||Cai, Qian., Tammineni, Prasad., (2017) , Mitochondrial aspects of synaptic dysfunction in Alzheimer’s disease , Journal of Alzheimer\'s Disease, IOS press,57,4,1087-1103.|
|13||Feng, Tuancheng., Tammineni, Prasad., Agrawal, Chanchal., Jeong, Yu Young., Cai, Qian., (2017) , Autophagy-mediated regulation of BACE1 protein trafficking and degradation , Journal of Biological Chemistry, American Society for Biochemistry and Molecular Biology,292,5,1679-1690.|
|12||Norris, Anne., Tammineni, Prasad., Wang, Simon., Gerdes, Julianne., Murr, Alexandra., Kwan, Kelvin Y., Cai, Qian., Grant, Barth D., (2017) , SNX-1 and RME-8 oppose the assembly of HGRS-1/ESCRT-0 degradative microdomains on endosomes , Proceedings of the National Academy of Sciences, National Academy of Sciences,114,3,E307-E316.|
|11||Tammineni, Prasad., Ye, Xuan., Feng, Tuancheng., Aikal, Daniyal., Cai, Qian., (2017) , Impaired retrograde transport of axonal autophagosomes contributes to autophagic stress in Alzheimer’s disease neurons , Elife, eLife Sciences Publications Limited,6,,e21776.|
|10||Ye, Xuan., Feng, Tuancheng., Tammineni, Prasad., Chang, Qing., Jeong, Yu Young., Margolis, David J., Cai, Huaibin., Kusnecov, Alexander., Cai, Qian., (2017) , Regulation of synaptic amyloid-β generation through BACE1 retrograde transport in a mouse model of Alzheimer\'s disease , Journal of Neuroscience, Society for Neuroscience,37,10,2639-2655.|
|9||Tammineni, Prasad., Cai, Qian., (2017) , Defective retrograde transport impairs autophagic clearance in Alzheimer disease neurons , Autophagy, Taylor & Francis,13,5,982-984.|
|8||Lin, Mei-Yao., Cheng, Xiu-Tang., Tammineni, Prasad., Xie, Yuxiang., Zhou, Bing., Cai, Qian., Sheng, Zu-Hang., (2017) , Releasing syntaphilin removes stressed mitochondria from axons independent of mitophagy under pathophysiological conditions , Neuron, Cell Press,94,3,595-610. e6.|
|7||Tammineni, Prasad., Jeong, Yu Young., Feng, Tuancheng., Aikal, Daniyal., Cai, Qian., (2017) , Impaired axonal retrograde trafficking of the retromer complex augments lysosomal deficits in Alzheimer’s disease neurons , Human molecular genetics, Oxford University Press,26,22,4352-4366.|
|6||Cai, Qian., Tammineni, Prasad., (2016) , Alterations in mitochondrial quality control in Alzheimer’s disease , Frontiers in cellular neuroscience, Frontiers,10,,24.|
|5||Sepuri, Naresh Babu V., Tammineni, Prasad., Mohammed, Fareed., Paripati, Arunkumar., (2016) , Nuclear transcription factors in the mitochondria: a new paradigm in fine-tuning mitochondrial metabolism , Pharmacology of mitochondria, Springer, Cham,,,3-20.|
|4||Murari, Anjaneyulu., Thiriveedi, Venkata Ramana., Mohammad, Fareed., Vengaldas, Viswamithra., Gorla, Madhavi., Tammineni, Prasad., Krishnamoorthy, Thanuja., Sepuri, Naresh Babu V., (2015) , Human mitochondrial MIA40 (CHCHD4) is a component of the Fe–S cluster export machinery , Biochemical Journal, Portland Press Limited,471,2,231-241.|
|3||Nishanth, Reddy P., Prasad, Tammineni., Jyotsna, Radhika G., Reddy, Pratap K., Reddanna, Pallu., (2014) , Hepatoprotective effects of Terminalia chebula fruit extract against 2-AAF–induced hepatic damage in Albino mice: role of MDR1 and COX-2 , Journal of herbs, spices & medicinal plants, Taylor & Francis,20,4,402-420.|
|2||Tammineni, Prasad., Anugula, Chandrashekhar., Mohammed, Fareed., Anjaneyulu, Murari., Larner, Andrew C., Sepuri, Naresh Babu Venkata., (2013) , The import of the transcription factor STAT3 into mitochondria depends on GRIM-19, a component of the electron transport chain , Journal of Biological Chemistry, American Society for Biochemistry and Molecular Biology,288,7,4723-4732.|
|1||Marada, Adinarayana., Allu, Praveen Kumar., Murari, Anjaneyulu., PullaReddy, BhoomiReddy., Tammineni, Prasad., Thiriveedi, Venkata Ramana., Danduprolu, Jayasree., Sepuri, Naresh Babu V., (2013) , Mge1, a nucleotide exchange factor of Hsp70, acts as an oxidative sensor to regulate mitochondrial Hsp70 function , Molecular biology of the cell, The American Society for Cell Biology,24,6,692-703.|
We are always looking for highly motivated researchers across multiple positions!
If you are interested in understanding the mechanisms regulating neuronal health and disease, send an email with your CV to Tammineni: email@example.com
: We welcome graduate students through PhD program at Department of Animal Biology. Candidates with CSIR-JRF will be given preference, but not essential.
: We are open to train students across different educational backgrounds. To apply for a position, please send me an inquiry email describing your research interests and expectations along with your CV.
: We are also interested in motivated postdocs. Prospective postdocs are encouraged to send me an email with definite research questions, career goals and a CV. Postdocs with independent funding will be encouraged.
The goal of Tammineni lab is to provide an environment where science can be done with free spirit. We are committed to train students, postdocs, and research technicians towards their goals. We are open to discussions, collaborations and thrive on honesty and ethical values while pursuing science.
Neurodegenerative diseases affect a staggering percentage of population worldwide. However, these diseases are often untreatable because of the lack of our understanding of the disease biology. The overarching goal of my research is to investigate molecular mechanisms of membrane trafficking and quality control pathways in neurodegenerative disorders especially Parkinson's Disease (PD) and Alzheimer's Disease (AD). Using transgenic mouse models of AD and PD and state-of-the art imaging modules combined with classic biochemical approaches, we are particularly interested in addressing the following questions; (1) Understanding the interplay between endo-lysosomal and mitochondrial trafficking and quality control (2) Relevance of autophagy and other quality control mechanisms in early onset or progression of Neurodegenerative diseaes; (3) cytoskeletal remodeling during axon transport and neuronal communication. My long-term goal is to establish how trafficking pathways are coupled with quality control mechanisms and synaptic transmission in neuronal health and disease. Considering the importance of quality control pathways in clearing the protein aggregates and damaged organelles in Neurodegenerative diseases, better understanding of these processes could also open new avenues for designing therapeutics.
Membrane Trafficking in Neuronal Health and Disease