Faculty
Faculty Details
Faculty Details
Prasad Tammineni, Ph.D. is an Assistant Professor in the Department of Animal Biology at the University of Hyderabad (UoH). During his PhD, at University of Hyderabad, Dr. Tammineni was supported by CSIR fellowship to understand the mechanistic details of STAT3 transport to mitochondria and its non-canonical functions in redox homeostasis. He then moved to Rutgers University (USA) to conduct postdoctoral research on endo-lysosomal trafficking and autophagy regulation in Alzheimer's Disease, using transgenic mouse models and state-of-the art imaging modules. Dr. Tammineni then moved to MIT (USA), as a Picower Research Fellow, to investigate the mechanisms of synaptic plasticity in neurodevelopmental and neuropsychiatric disorders. Dr. Tammineni now runs a Molecular Neurosciences lab at UoH. Overarching goal of his research group is to understand the molecular mechanisms of membrane trafficking and how organelle/protein quality control is regulated in neuronal health and disease.
Education/Training
Picower Research Fellow – MIT, USA
Postdoctoral Research Associate – Rutgers University, USA
PhD
MS – S.V. University, Tirupathi
Postdoctoral
Awards
JPB Foundation-MIT Fellowship – MIT- JPB Foundation (2018)
Outstanding Postdoctoral Research Award – Rutgers University, USA (2018)
Doctoral
Awards
K. V. Rao Young Scientist Award (2013)
CSIR Fellowship (2009-2014)
You can follow our lab updates here or on Pubmed
Lab Website
Students/Projects Trainees
| Name | Joined As | Contact | |
|---|---|---|---|
| Anusruti Sabui | Graduate Student | --- | --- |
| Mitali Biswas | Graduate Student | --- | --- |
| A Vigneshwar Reddy | Graduate Student | --- | --- |
| Rishab | Master's Thesis Student | --- | --- |
| Sofia | Master's thesis student | --- | --- |
Former Students/Projects Trainees
| Name | Joined As | Working |
|---|---|---|
| Janakiramulu Pasula | Project Assistant | |
| Kashmiri Manishrao Lande | Winter Internship Student | Kashmiri is now a Junior Research Fellow at CCMB, Hyderabad |
| Preethi Kandagiri | MSc Thesis Project | Preethi is a Junior Research Fellow at NIAB, Hyderabad |
| Rajyalaxmi | MSc thesis Project | |
| Ghazala Rahman | Master's thesis Student | Currently a grad student at IIT, Hyderabad |
| Vismitha Nadig | Int. MSc thesis student | PhD in Max Planck, Germany |
| 20 | Jeong YY, Han S, Jia N, Zhang M, Sheshadri P, Tammineni P, Cheung J, Nissenbaum M, Baskar SS, Kwan K, Margolis DJ, Jiang P, Kusnecov AW, Cai Q. (2022) , Broad activation of the Parkin pathway induces synaptic mitochondrial deficits in early tauopathy. , Brain, Oxford University Press,145 (1),35022692,305-323. |
| 19 | Nyshadham SN Chaitanya, Prasad Tammineni, Ganji Purnachandra Nagaraju, Aramati BM Reddy (2022) , Pleiotropic roles of evolutionarily conserved signaling intermediate in toll pathway (ECSIT) in pathophysiology , Journal of Cellular Physiology, ,,doi: 10.1002/jcp.30832,. |
| 18 | Sabui A, Biswas M, Somvanshi PR, Kandagiri P, Gorla M, Mohammed F, Tammineni P*. (2022) , Decreased anterograde transport coupled with sustained retrograde transport contributes to reduced axonal mitochondrial density in tauopathy neurons , Frontiers in Molecular Neurosciences, ,,,. |
| 17 | Rajkishor Nishad, Dhanunjay Mukhi, Ashish Kumar Singh, Manga Motrapu, Kumaraswami Chintala, Prasad Tammineni, and Anil K. Pasupulati (2021) , Growth hormone induces mitotic catastrophe of glomerular podocytes and contributes to proteinuria , Cell Death and Disease, ,10.1038/s41419-021-03643-6,,. |
| 16 | Mohammed F, Gorla M, Bisoyi V, Tammineni P*, Sepuri NBV* (2020) , Rotenone-induced reactive oxygen species signal the recruitment of STAT3 to mitochondria , FEBS Letters, FEBS Press,doi: 10.1002/1873-3468.13741,,. |
| 15 | Rathje M, Waxman H, Benoit M, Tammineni P, Leu C, Loebrich S, Nedivi E (2019) , Genetic variants in the bipolar disorder risk locus SYNE1 that affect CPG2 expression and protein function , Mol. Psychiatry, Nature Publishing Group,doi: 10.1038/s41380-018-0314-z,,. |
| 14 | Cai, Qian., Tammineni, Prasad., (2017) , Mitochondrial aspects of synaptic dysfunction in Alzheimer’s disease , Journal of Alzheimer\'s Disease, IOS press,57,4,1087-1103. |
| 13 | Feng, Tuancheng., Tammineni, Prasad., Agrawal, Chanchal., Jeong, Yu Young., Cai, Qian., (2017) , Autophagy-mediated regulation of BACE1 protein trafficking and degradation , Journal of Biological Chemistry, American Society for Biochemistry and Molecular Biology,292,5,1679-1690. |
| 12 | Norris, Anne., Tammineni, Prasad., Wang, Simon., Gerdes, Julianne., Murr, Alexandra., Kwan, Kelvin Y., Cai, Qian., Grant, Barth D., (2017) , SNX-1 and RME-8 oppose the assembly of HGRS-1/ESCRT-0 degradative microdomains on endosomes , Proceedings of the National Academy of Sciences, National Academy of Sciences,114,3,E307-E316. |
| 11 | Tammineni, Prasad., Ye, Xuan., Feng, Tuancheng., Aikal, Daniyal., Cai, Qian., (2017) , Impaired retrograde transport of axonal autophagosomes contributes to autophagic stress in Alzheimer’s disease neurons , Elife, eLife Sciences Publications Limited,6,,e21776. |
| 10 | Ye, Xuan., Feng, Tuancheng., Tammineni, Prasad., Chang, Qing., Jeong, Yu Young., Margolis, David J., Cai, Huaibin., Kusnecov, Alexander., Cai, Qian., (2017) , Regulation of synaptic amyloid-β generation through BACE1 retrograde transport in a mouse model of Alzheimer\'s disease , Journal of Neuroscience, Society for Neuroscience,37,10,2639-2655. |
| 9 | Tammineni, Prasad., Cai, Qian., (2017) , Defective retrograde transport impairs autophagic clearance in Alzheimer disease neurons , Autophagy, Taylor & Francis,13,5,982-984. |
| 8 | Lin, Mei-Yao., Cheng, Xiu-Tang., Tammineni, Prasad., Xie, Yuxiang., Zhou, Bing., Cai, Qian., Sheng, Zu-Hang., (2017) , Releasing syntaphilin removes stressed mitochondria from axons independent of mitophagy under pathophysiological conditions , Neuron, Cell Press,94,3,595-610. e6. |
| 7 | Tammineni, Prasad., Jeong, Yu Young., Feng, Tuancheng., Aikal, Daniyal., Cai, Qian., (2017) , Impaired axonal retrograde trafficking of the retromer complex augments lysosomal deficits in Alzheimer’s disease neurons , Human molecular genetics, Oxford University Press,26,22,4352-4366. |
| 6 | Cai, Qian., Tammineni, Prasad., (2016) , Alterations in mitochondrial quality control in Alzheimer’s disease , Frontiers in cellular neuroscience, Frontiers,10,,24. |
| 5 | Sepuri, Naresh Babu V., Tammineni, Prasad., Mohammed, Fareed., Paripati, Arunkumar., (2016) , Nuclear transcription factors in the mitochondria: a new paradigm in fine-tuning mitochondrial metabolism , Pharmacology of mitochondria, Springer, Cham,,,3-20. |
| 4 | Murari, Anjaneyulu., Thiriveedi, Venkata Ramana., Mohammad, Fareed., Vengaldas, Viswamithra., Gorla, Madhavi., Tammineni, Prasad., Krishnamoorthy, Thanuja., Sepuri, Naresh Babu V., (2015) , Human mitochondrial MIA40 (CHCHD4) is a component of the Fe–S cluster export machinery , Biochemical Journal, Portland Press Limited,471,2,231-241. |
| 3 | Nishanth, Reddy P., Prasad, Tammineni., Jyotsna, Radhika G., Reddy, Pratap K., Reddanna, Pallu., (2014) , Hepatoprotective effects of Terminalia chebula fruit extract against 2-AAF–induced hepatic damage in Albino mice: role of MDR1 and COX-2 , Journal of herbs, spices & medicinal plants, Taylor & Francis,20,4,402-420. |
| 2 | Tammineni, Prasad., Anugula, Chandrashekhar., Mohammed, Fareed., Anjaneyulu, Murari., Larner, Andrew C., Sepuri, Naresh Babu Venkata., (2013) , The import of the transcription factor STAT3 into mitochondria depends on GRIM-19, a component of the electron transport chain , Journal of Biological Chemistry, American Society for Biochemistry and Molecular Biology,288,7,4723-4732. |
| 1 | Marada, Adinarayana., Allu, Praveen Kumar., Murari, Anjaneyulu., PullaReddy, BhoomiReddy., Tammineni, Prasad., Thiriveedi, Venkata Ramana., Danduprolu, Jayasree., Sepuri, Naresh Babu V., (2013) , Mge1, a nucleotide exchange factor of Hsp70, acts as an oxidative sensor to regulate mitochondrial Hsp70 function , Molecular biology of the cell, The American Society for Cell Biology,24,6,692-703. |
We are always looking for highly motivated
researchers across multiple positions!
If you are interested in understanding the
mechanisms regulating neuronal health and disease, send an email with your CV
to Tammineni: prasadtammineni@uohyd.ac.in
Graduate Students: We welcome graduate students through PhD program at Department of
Animal Biology. Candidates with CSIR-JRF will be given preference, but not
essential.
Research Technicians and
Internships: We are open to train students across
different educational backgrounds. To apply for a position, please send me an
inquiry email describing your research interests and expectations along with
your CV.
Postdocs: We are also interested in motivated postdocs. Prospective postdocs are encouraged to send me an email with definite research questions, career goals and a CV. Postdocs with independent funding will be encouraged.
The goal of Tammineni lab is to provide an
environment where science can be done with free spirit. We are committed to
train students, postdocs, and research technicians towards their goals. We are open to discussions, collaborations and thrive on honesty and ethical values while pursuing science.
Neurodegenerative diseases
affect a staggering percentage of population worldwide. However, these diseases are often untreatable because of
the lack of our understanding of the disease biology. The overarching goal of our lab is to investigate molecular mechanisms of membrane trafficking and quality control pathways in
neurodegenerative disorders with a special emphasis on Alzheimer's and Parkinson's Disease. Using transgenic mouse models of AD and PD and state-of-the art imaging approaches, we are investigating the following questions; (1) the interplay between endo-lysosomal and mitochondrial quality control (2) Relevance of autophagy and other quality control mechanisms in early onset or progression of Neurodegenerative diseaes; (3) cytoskeletal remodeling during axon transport and neuronal communication. My long-term goal is to establish how trafficking pathways are coupled with quality control mechanisms in neuronal health and disease.
Membrane Trafficking in Neuronal Health and Disease