is an Assistant Professor in the Department of Animal Biology at the University of Hyderabad (UoH). During his PhD, at University of Hyderabad, Dr. Tammineni was supported by CSIR fellowship to understand the mechanistic details of STAT3 transport to mitochondria and its non-canonical functions in redox homeostasis. He then moved to Rutgers University (USA) to conduct postdoc on endo-lysosomal trafficking and autophagy regulation in Alzheimer's Disease, using transgenic mouse models and state-of-the art imaging modules. Dr. Tammineni then moved to MIT (USA), as a Picower Research Fellow, to investigate the mechanisms of synaptic plasticity in neurodevelopmental and neuropsychiatric disorders. Dr. Tammineni now runs a Molecular Neurosciences lab at UoH. Overarching goal of his research group is to understand the molecular mechanisms and regulation of membrane trafficking and organelle/protein quality control in neuronal health and disease.
|Janakiramulu Pasula||Project Assistantfirstname.lastname@example.org||7661011845|
|Preethi Kandagiri||MSc Thesis Projectemail@example.com||---|
|Rajyalaxmi||MSc thesis Projectfirstname.lastname@example.org||---|
Former Students/Projects Trainees
|Kashmiri Manishrao Lande||Winter Internship Student||Kashmiri is our own student pursuing towards Master's degree in Animal Biology. She finished her B.Sc. (Zoology) from Fergusson College, Pune before joining UoH.|
|16||Mohammed F, Gorla M, Bisoyi V, Tammineni P, Sepuri NBV (2020) , Rotenone-induced reactive oxygen species signal the recruitment of STAT3 to mitochondria , FEBS Letters, FEBS Press,doi: 10.1002/1873-3468.13741,,.|
|15||Rathje M, Waxman H, Benoit M, Tammineni P, Leu C, Loebrich S, Nedivi E (2019) , Genetic variants in the bipolar disorder risk locus SYNE1 that affect CPG2 expression and protein function , Mol. Psychiatry, Nature Publishing Group,doi: 10.1038/s41380-018-0314-z,,.|
|14||Cai, Qian., Tammineni, Prasad., (2017) , Mitochondrial aspects of synaptic dysfunction in Alzheimer’s disease , Journal of Alzheimer\'s Disease, IOS press,57,4,1087-1103.|
|13||Feng, Tuancheng., Tammineni, Prasad., Agrawal, Chanchal., Jeong, Yu Young., Cai, Qian., (2017) , Autophagy-mediated regulation of BACE1 protein trafficking and degradation , Journal of Biological Chemistry, American Society for Biochemistry and Molecular Biology,292,5,1679-1690.|
|12||Norris, Anne., Tammineni, Prasad., Wang, Simon., Gerdes, Julianne., Murr, Alexandra., Kwan, Kelvin Y., Cai, Qian., Grant, Barth D., (2017) , SNX-1 and RME-8 oppose the assembly of HGRS-1/ESCRT-0 degradative microdomains on endosomes , Proceedings of the National Academy of Sciences, National Academy of Sciences,114,3,E307-E316.|
|11||Tammineni, Prasad., Ye, Xuan., Feng, Tuancheng., Aikal, Daniyal., Cai, Qian., (2017) , Impaired retrograde transport of axonal autophagosomes contributes to autophagic stress in Alzheimer’s disease neurons , Elife, eLife Sciences Publications Limited,6,,e21776.|
|10||Ye, Xuan., Feng, Tuancheng., Tammineni, Prasad., Chang, Qing., Jeong, Yu Young., Margolis, David J., Cai, Huaibin., Kusnecov, Alexander., Cai, Qian., (2017) , Regulation of synaptic amyloid-β generation through BACE1 retrograde transport in a mouse model of Alzheimer\'s disease , Journal of Neuroscience, Society for Neuroscience,37,10,2639-2655.|
|9||Tammineni, Prasad., Cai, Qian., (2017) , Defective retrograde transport impairs autophagic clearance in Alzheimer disease neurons , Autophagy, Taylor & Francis,13,5,982-984.|
|8||Lin, Mei-Yao., Cheng, Xiu-Tang., Tammineni, Prasad., Xie, Yuxiang., Zhou, Bing., Cai, Qian., Sheng, Zu-Hang., (2017) , Releasing syntaphilin removes stressed mitochondria from axons independent of mitophagy under pathophysiological conditions , Neuron, Cell Press,94,3,595-610. e6.|
|7||Tammineni, Prasad., Jeong, Yu Young., Feng, Tuancheng., Aikal, Daniyal., Cai, Qian., (2017) , Impaired axonal retrograde trafficking of the retromer complex augments lysosomal deficits in Alzheimer’s disease neurons , Human molecular genetics, Oxford University Press,26,22,4352-4366.|
|6||Cai, Qian., Tammineni, Prasad., (2016) , Alterations in mitochondrial quality control in Alzheimer’s disease , Frontiers in cellular neuroscience, Frontiers,10,,24.|
|5||Sepuri, Naresh Babu V., Tammineni, Prasad., Mohammed, Fareed., Paripati, Arunkumar., (2016) , Nuclear transcription factors in the mitochondria: a new paradigm in fine-tuning mitochondrial metabolism , Pharmacology of mitochondria, Springer, Cham,,,3-20.|
|4||Murari, Anjaneyulu., Thiriveedi, Venkata Ramana., Mohammad, Fareed., Vengaldas, Viswamithra., Gorla, Madhavi., Tammineni, Prasad., Krishnamoorthy, Thanuja., Sepuri, Naresh Babu V., (2015) , Human mitochondrial MIA40 (CHCHD4) is a component of the Fe–S cluster export machinery , Biochemical Journal, Portland Press Limited,471,2,231-241.|
|3||Nishanth, Reddy P., Prasad, Tammineni., Jyotsna, Radhika G., Reddy, Pratap K., Reddanna, Pallu., (2014) , Hepatoprotective effects of Terminalia chebula fruit extract against 2-AAF–induced hepatic damage in Albino mice: role of MDR1 and COX-2 , Journal of herbs, spices & medicinal plants, Taylor & Francis,20,4,402-420.|
|2||Tammineni, Prasad., Anugula, Chandrashekhar., Mohammed, Fareed., Anjaneyulu, Murari., Larner, Andrew C., Sepuri, Naresh Babu Venkata., (2013) , The import of the transcription factor STAT3 into mitochondria depends on GRIM-19, a component of the electron transport chain , Journal of Biological Chemistry, American Society for Biochemistry and Molecular Biology,288,7,4723-4732.|
|1||Marada, Adinarayana., Allu, Praveen Kumar., Murari, Anjaneyulu., PullaReddy, BhoomiReddy., Tammineni, Prasad., Thiriveedi, Venkata Ramana., Danduprolu, Jayasree., Sepuri, Naresh Babu V., (2013) , Mge1, a nucleotide exchange factor of Hsp70, acts as an oxidative sensor to regulate mitochondrial Hsp70 function , Molecular biology of the cell, The American Society for Cell Biology,24,6,692-703.|
27 August 2020: We are back in business.. University started online classes from 20 Aug. A step forward to keep the academics going... Hopefully, our research programs start hitting the road real soon!
01 Aug 2020: University remains closed until 31 Aug 2020. Stay put and safe!
13 May 2020: My lab is recruiting two PhD students and 1 project JRF. Interested candidates may shoot an email
3 May 2020: One more ICMR grant to Tammineni lab...!!! Some good news amidst the pandemic.
2 May 2020: Lock down is extended further and we are hoping that University will resume back to functionality sometimes in late June or early July. Stay Home and Stay Safe!
10 April 2020: University of Hyderabad is accepting applications for admission to MSc and PhD courses. You can find more details here: http://acad.uohyd.ac.in/ee20.html
26 March 2020: Due to Corona Pandemic, we are closed until the end of this month. We are not accepting any applications for the summer internships.
22 Feb 2020: Yayyy....Lab is ON from today onwards.... Hopefully you will see some working hands from next week....!!! Thanks everyone for their wishes....
31 Jan 2020: Preethi and Rajyalaxmi joins the lab for their MSc thesis project. Welcome Preethi and Rajyalaxmi..!!!
25 Jan 2020: A collaborative work with Prof. Sepuri is published in FEBS Letter. Congratulations both the labs
23 Jan 2020: ICMR extramural grant to Tammineni lab.
31 Dec 2019: Tammineni lab got SERB Startup Research Grant
06 Sep 2019: Tammineni Lab got UGC Startup Research Grant
We are always looking for highly motivated researchers across multiple positions!
If you are interested in understanding the mechanisms regulating neuronal health and disease, send an email with your CV to Tammineni: email@example.com
: We welcome graduate students through PhD program at Department of Animal Biology. Candidates with CSIR-JRF will be given preference, but not essential.
: We are open to train students across different educational backgrounds. To apply for a position, please send me an inquiry email describing your research interests and expectations along with your CV.
: We are also interested in motivated postdocs. Prospective postdocs are encouraged to send me an email with definite research questions, career goals and a CV. Postdocs with independent funding will be encouraged.
The goal of Tammineni lab is to provide an environment where science can be done with free spirit. We are committed to train students, postdocs, and research technicians so that they can achieve what they deserve. We are open to discussions, collaborations and thrive on honesty and ethical values while pursuing science.
Neurodegenerative diseases affect a staggering percentage of population worldwide. However, these diseases are often untreatable because of the lack of our understanding of the disease biology. The overarching goal of my research is to investigate molecular mechanisms of membrane trafficking and quality control pathways in neurodegenerative disorders especially Parkinson's Disease (PD) and Alzheimer's Disease (AD). Using transgenic mouse models of AD and PD and state-of-the art imaging modules combined with classic biochemical approaches, we are particularly interested in addressing the following questions; (1) To understanding how endosomal and mitochondrial transport is specialized and regulated in neurons; (2) How neurons coordinate the transport and the quality control of different organelles during early onset and progression of neurodegenerative disorders; (3) cytoskeletal remodeling during axon transport and synaptic plasticity. My long-term goal is to establish how trafficking pathways are coupled with quality control mechanisms and synaptic transmission in neuronal health and disease. Pursuing this elemental research will advance our knowledge of these fundamental processes, in the context of neurodegenerative diseases, and hopefully help us to design new therapeutic options.
Membrane Trafficking in Neuronal Health and Disease