Faculty Details

Faculty Details

  • Name: Dr. Insaf Ahmed Qureshi
  • Mail: insafuohyd.ac.in
  • Contact: 040-23134588
  • Area Of Research:Protein Biochemistry and Structural Biology
Dr. Qureshi’s laboratory at UoH is working on to understand the role of various proteins involved in phosphorylation and protein degradation in leishmaniasis through structural and functional approaches and further translate these findings towards the development of novel therapeutics to treat neglected disease like kala-azar.
Dr. Qureshi has published more than 75 research papers in international and national journals, and his group has received extramural research grants from various funding agencies like SERB, ICMR, CSIR etc. Notably, his two PhD students have received the prestigious Prime Minister's Research Fellowship (PMRF). He has been the recipient of several awards and fellowships including ICMR Award (2010), Indo-US Raman Fellowship (2014), ICMR International Fellowship (2018) etc. He has been elected as Fellow, Telangana Academy of Sciences, and is also conferred with the life membership by National Academy of Sciences, India (NASI) and National Academy of Medical Sciences (NAMS).

No Records Available

Students/Projects Trainees

Name Joined As Mail Contact
J. Pranay PhD Scholar-PMRF pranay.jakkula179@gmail.com ---
Janish Kumar PhD Scholar janishkumarsvc@gmail.com ---
Jyotisha PhD Scholar-PMRF joyti.94@gmail.com ---
Fouzia Nasim PhD Scholar 16ltpm02@uohyd.ac.in ---

Former Students/Projects Trainees

Name Joined As Working
Santhosh Gatreddi PhD Scholar Postdoctoral Fellow in Michigan State University, USA
Sayanna Are PhD Scholar Postdoctoral Fellow in University of California, Irvine, USA
Saleem Yousuf Bhat PhD Scholar Postdoctoral Fellow in USA
B. Narsimulu PhD Scholar Postdoctoral Fellow in University of California, Riverside, USA
59 Nasim F, Kumar MS, Alvala M, Qureshi IA. (2024) , Unraveling the peculiarities of leishmanial arginyl-tRNA synthetase and development of its novel inhibitors. , FEBS Journal, ,,, IF - 5.6.
58 Narsimulu B, Jakkula P, Qureshi R, Nasim F, Qureshi IA. (2024) , Inhibition and structural insights of leishmanial glutamyl-tRNA synthetase for designing potent therapeutics. , International Journal of Biological Macromolecules , ,254,127756, IF - 8.2.
57 Narsimulu B, Qureshi R, Jakkula P, Singh P, Arifuddin M, Qureshi IA. (2023) , Exploration of seryl tRNA synthetase to identify potent inhibitors against leishmanial parasites , International Journal of Biological Macromolecules, ,237,124118, IF - 8.2.
56 Nasim F, Qureshi IA. (2023) , Aminoacyl tRNA Synthetases: Implications of Structural Biology in Drug Development against Trypanosomatid Parasites , ACS Omega, ,8,,14884-14899 IF - 4.132.
55 Sardar S, Jyotisha, Amin SA, Khatun S, Qureshi IA, Patil UK, Jha T, Gayen S. (2023) , Identification of structural fingerprints among natural inhibitors of HDAC1 to accelerate nature-inspired drug discovery in cancer epigenetics. , Journal of Biomolecular Structure and Dynamics, ,,, IF - 4.4.
54 Jyotisha, Qureshi R, Qureshi IA . (2023) , Development of a multi-epitope vaccine candidate for leishmanial parasites applying immunoinformatics and in vitro approaches. , Frontiers in Immunology, ,14,1269774, IF - 7.3.
53 Jyotisha, Singh S, Qureshi IA. (2022) , Multi-epitope vaccine against SARS-CoV-2 applying immunoinformatics and molecular dynamics simulation approaches. , Journal of Biomolecular Structure and Dynamics, ,40,,2917-2933 IF - 4.4.
52 Amin SA, Ghosh K, Singh S, Qureshi IA, Gayen S, Jha T . (2022) , Exploring naphthyl derivatives as SARS-CoV papain-like protease (PLpro) inhibitors and its implications in COVID-19 drug discovery. , Molecular Diversity , ,26,,215-228 IF - 3.364.
51 Narsimulu B, Qureshi R, Jakkula P, Are S, Qureshi IA. (2022) , Biophysical and Structural Characterization of Ribulose-5-phosphate Epimerase from Leishmania donovani. , ACS Omega , ,7,,548–564 IF - 4.132.
50 Amin SA, Kumar J, Khatun S, Das S, Qureshi IA, Jha T, Gayen S. (2022) , Binary Quantitative activity-activity relationship (QAAR) studies to explore selective HDAC8 inhibitors: In light of mathematical models, DFT-based calculation and molecular dynamic simulation studies. , Journal of Molecular Structure , ,1260,132833, IF - 3.841.
49 Amobonye A, Singh S, Mukherjee K, Jobichen C, Qureshi IA*, Pillai S* . (2022) , Structural and functional insights into fungal glutaminase using a computational approach. , Process Biochemistry, ,117,,76-89 IF - 4.885.
48 Singh S, Qureshi IA . (2022) , Identification of potent inhibitors against Chorismate synthase of Toxoplasma gondii using molecular dynamics simulations. , Journal of Molecular Graphics and Modelling, ,114,108183, IF - 2.942.
47 Saini M, Are S, Qureshi IA. (2022) , Pyridoxal kinase of disease-causing human parasites: structural and functional insights to understand its role in drug discovery. , Current Protein , ,,, IF - 3.183.
46 Nasim F, Qureshi IA (2022) , Role of Structural Biology Methods in Drug Discovery , Advances in Protein Molecular and Structural Biology Methods, Elsevier,,,.
45 Sethi A, Sasikala K, Jakkula P, Gadde D, Sanam S, Qureshi IA, Talla V, Alvala M (2021) , Design, synthesis and computational studies involving Indole-Coumarin hybrids as galectin-1 inhibitors. , Chemical Papers, ,75,,2791-2805 IF - 2.097.
44 Bhat SY, Bhandari S, Thacker PS, Arifuddin M, Qureshi IA. (2021) , Development of quinoline-based hybrid as inhibitor of methionine aminopeptidase 1 from Leishmania donovani. , Chemical Biology and Drug Design, ,97,,315-324 IF - 2.817.
43 Kumar J, Qureshi R, Sagurthi SR, Qureshi IA. (2021) , Designing of nucleocapsid protein based novel multi-epitope vaccine against SARS-COV-2 using immunoinformatics approach. , International Journal of Peptide Research and Therapeutics, ,27,,941-956.
42 Amin SA, Banerjee S, Singh S, Qureshi IA, Gayen S, Jha T. (2021) , First structure-activity relationship analysis of SARS-CoV-2 virus main protease (Mpro) inhibitors: An endeavour on COVID-19 drug discovery. , Molecular Diversity, ,25,,1827-1838 IF - 2.943.
41 Neupane NP, Karn AK, Mukeri IH, Pathak P, Sharma PK, Singh S, Qureshi IA, Jha T, Verma A (2021) , Molecular dynamics analysis of phytochemicals from Ageratina adenophora against COVID-19 main protease (Mpro) and human angiotensin-converting enzyme 2 (ACE2) , Biocatalysis and Agricultural Biotechnology , ,32,101924,.
40 Neupane NP, Karn AK, Mukeri IH, Pathak P, Sharma PK, Singh S, Qureshi IA, Jha T, Verma A. (2021) , Molecular dynamics analysis of phytochemicals from Ageratina adenophora against COVID-19 main protease (Mpro) and human angiotensin-converting enzyme 2 (ACE2). , Biocatalysis and Agricultural Biotechnology, ,32,,101924.
39 Nasim F, Dey A, Qureshi IA. (2021) , Comparative genome analysis of Corynebacterium species: The underestimated pathogens with high virulence potential. , Infection, Genetics and Evolution, ,93,,104928 IF - 4.393.
38 Korasick DA, Christgen SL, Qureshi IA, Becker DF, Tanner JJ. (2021) , Probing the function of a ligand-modulated dynamic tunnel in bifunctional proline utilization A (PutA). , Archives of Biochemistry and Biophysics, ,712,,109025 IF - 4.013.
37 Bhat SY, Qureshi IA. (2021) , Structural and functional basis of potent inhibition of leishmanial leucine aminopeptidase by peptidomimetics. , ACS Omega, ,6,,19076-19085 IF - 3.512.
36 Khan AN, Qureshi IA, Khan UK, Uversky VN, Khan RH. (2021) , Inhibition and disruption of amyloid formation by the antibiotic levofloxacin: A new direction for antibiotics in an era of multi-drug resistance. , Archives of Biochemistry and Biophysics, ,714,,109077 IF - 4.013.
35 Jakkula P, Narsimulu B, Qureshi IA. (2021) , Biochemical and structural insights into 6-phosphogluconate dehydrogenase from Leishmania donovani. , Applied Microbiology and Biotechnology, ,105,,5471-5489 IF - 5.56.
34 Bhat SY, Qureshi IA (2020) , Mutations of key substrate binding residues of leishmanial peptidase T alter its functional and structural dynamics. , BBA General Subjects , ,1864,,129465.
33 Bhat SY, Jagruthi P, Srinivas A, Arifuddin M, Qureshi IA, (2020) , Synthesis and characterization of quinoline-carbaldehyde derivatives as novel inhibitors for leishmanial methionine aminopeptidase 1. , European Journal of Medicinal Chemistry , ,186,111860, IF - 5.6.
32 Goud N, Makani VKK, Jakkula P, Alvala R, Qureshi IA, Kumar P, Bharath RD, Nagaraj, C, Yerramasetti S, Bhadra MP, Alvala M. (2020) , Synthesis, 18F-radiolabeling and apoptosis inducing studies of novel 4, 7- di substituted coumarins. , Bioorganic Chemistry, ,97,103663, IF - 4.8.
31 Are S, Gatreddi S, Jakkula P, Qureshi IA. (2020) , Structural attributes and substrate specificity of pyridoxal kinase from Leishmania donovani. , International Journal of Biological Macromolecules, ,152,,812-827 IF - 5.2.
30 Goud NS, Pooladanda V, Muni Chandra K, Lakshmi Soukya PS, Alvala R, Kumar P, Nagaraj C, Dawn Bharath R, Qureshi IA, Godugu C, Alvala M. (2020) , Novel benzimidazole-triazole hybrids as apoptosis inducing agents in lung cancer: Design, synthesis, 18F-radiolabeling , Bioorganic Chemistry, ,102,104125, IF - 4.8.
29 Panigrahi GC, Qureshi R, Jakkula P, Kumar KA, Khan N, Qureshi IA. (2020) , Leishmanial aspartyl-tRNA synthetase: Biochemical, biophysical and structural insights. , International Journal of Biological Macromolecules, ,165,,2869-2885 IF - 5.2.
28 Wyatt JW, Korasick DA, Qureshi IA, Campbell AC, Gates KS, Tanner JJ. (2020) , Inhibition, crystal structures, and in-solution oligomeric structure of aldehyde dehydrogenase 9A1. , Archives of Biochemistry and Biophysics, ,691,108477, IF - 3.5.
27 Gatreddi S, Pillalamarri V, Vasudevan D, Addlagatta A, Qureshi IA (2019) , Unraveling structural insights of ribokinase from Leishmania donovani. , International Journal of Biological Macromolecules , ,136,,253-265.
26 Qureshi R, Jakkula P, Sagurthi SR, Qureshi IA (2019) , Protein phosphatase 1 of Leishmania donovani exhibits conserved catalytic residues and pro-inflammatory response , Biochemical and Biophysical Research Communications , ,516,,770-776.
25 Goud NS, Ghouse SM, Vishnu J, Komal D, Talla V, Alvala R, Pranay J, Kumar J, Qureshi IA, Alvala M (2019) , Synthesis of 1-benzyl-1H-benzimidazoles as galectin-1 mediated anticancer agents , Bioorganic Chemistry , ,89,,103016.
24 Goud NS, Pooladanda V, Mahammad SG, Jakkula P, Gatreddi S, Qureshi IA, Alvala R, Godugu C, Alvala M (2019) , Synthesis and Biological evaluation of morpholines linked coumarin-triazole hybrids as anticancer agents , Chemical Biology and Drug Design, ,,,.
23 Goud NS, Ghouse SM, Vishnu J, Pranay J, Alvala R, Talla V, Qureshi IA, Alvala M (2019) , Synthesis and Biological Evaluation of Novel Heterocyclic Imines Linked Coumarin-Thiazole Hybrids as Anticancer Agents , Anti-Cancer Agents in Medicinal Chemistry, ,19,4,557-566.
22 Gatreddi S, Are S, Qureshi IA (2018) , Ribokinase from Leishmania donovani: Purification, characterization and x-ray crystallographic analysis , Acta Crystallography F , ,74,,99-104.
21 Jakkula P, Qureshi R, Iqbal A, Sagurthi SR, Qureshi IA (2018) , Leishmania donovani PP2C: Kinetics, structural attributes and in vitro immune response , Molecular and Biochemical Parasitology, ,223,,37-49.
20 Bhat SY, Dey A, Qureshi IA (2018) , Structural and functional highlights of methionine aminopeptidase 2 from Leishmania donovani , International Journal of Biological Macromolecules, ,115,,940-954.
19 Snigdha P, Rao PL, Prabhu NP, Qureshi IA. (2017) , Structural studies of aminopeptidase P from Plasmodium falciparum: a novel target against malaria. , Letters in Drug Design , ,14,,330-338.
18 Peddireddy V, Doddam SN, Qureshi IA, Yerra P, Ahmed N. (2016) , A putative nitroreductase from the DosR regulon of Mycobacterium tuberculosis induces pro-inflammatory cytokine expression via TLR2 signaling pathway. , Scientific Reports, ,6,24535, IF - 4.996.
17 Robinson R, Qureshi IA, Klancher CA, Rodriguez PJ, Tanner JJ, Sobrado P. (2015) , Contribution to catalysis of ornithine binding residues in ornithine N5-monooxygenase. , Archives of Biochemistry and Biophysics, ,585,,25-31.
16 Da Fonseca I*, Qureshi IA*, Mehra-Chaudhary R, Kizjakina K, Tanner JJ, Sobrado P. (2014) , Contributions of unique active site residues of eukaryotic UDP-galactopyranose mutases to substrate recognition and active site dynamics. , Biochemistry, ,53,,7794-7804.
15 Alag R, Balakrishna AM, Rajan S, Qureshi IA, Shin J, Lescar J, Grüber G, Yoon HS (2013) , Structural insights into substrate binding by PvFKBP35, a peptidylprolyl cis-trans isomerase from the human malarial parasite Plasmodium vivax. , Eukaryotic Cell , ,12,4,627-634.
14 Uppalapati SR, Kingston JJ, Qureshi IA, Murali HS, Batra HV (2013) , In silico, in vitro and in vivo analysis of binding affinity between N and C-domains of Clostridium perfringens alpha toxin , PLoS One , ,8,12,e82024.
13 Kumar A, Lewin A, Rani PS, Qureshi IA, Devi S, Majid M, Kamal E, Marek S, Hasnain SE, Ahmed N. (2013) , Dormancy Associated Translation Inhibitor (DATIN/Rv0079) of Mycobacterium tuberculosis interacts with TLR2 and induces proinflammatory cytokine expression. , Cytokine, ,64,,258-264.
12 Salman M, Malleda C, Suneel NA, Qureshi IA, Frank EA, D’Souza CJM (2011) , Homology modeling of human serum paraoxonase1 and its molecular interaction studies with aspirin and cefazolin , Bioinformation, ,7,2,59-63.
11 Gul MZ, Bhakshu LM, Ahmad F, Kondapi AK, Qureshi IA, Ghazi IA (2011) , Evaluation of Abelmoschus moschatus extracts for antioxidant, free radical scavenging, antimicrobial and antiproliferative activities using in vitro assays , BMC Complementary and Alternative Medicine, ,11,,64.
10 Smith HL, Liu XY, Dai L, Goh ET, Chan AT, Xi J, Seh CC, Qureshi IA, Lescar J, Ruedl C, Gourlay R, Morton S, Hough J, McIver EG, Cohen P, Cheung PC (2011) , The role of TBK1 and IKKε in the expression and activation of Pellino1 , Biochemical Journal , ,434,3,537-548.
9 Liew CW, Sharff A, Kotaka M, Kong R, Sun H, Qureshi IA, Bricogne G, Liang ZX, Lescar J (2010) , Induced-fit upon ligand binding revealed by crystal structures of the hot-dog fold thioesterase in dynemicin biosynthesis , Journal of Molecular Biology, ,404,2,291-306.
8 Alag R*, Qureshi IA*, Bharatham N, Shin J, Lescar J, Yoon HS (2010) , NMR and crystallographic structures of the FK506 binding domain of human malarial parasite Plasmodium vivax FKBP35 , Protein Science, ,19,8,1577-1586.
7 Gaur V, Qureshi IA, Singh A, Chanana V, Salunke DM (2010) , Crystal structure and functional insights of hemopexin fold protein from grass pea. , Plant Physiology, ,152,4,1842-1850.
6 Anandhan S, Qureshi IA, Koundal KR. (2010) , The cowpea trypsin inhibitor promoter drives expression in response to cellular maturation in Arabidopsis thaliana , Physiology and Molecular Biology of Plants, ,16,,31-37.
5 Kotaka M, Kong R, Qureshi IA, Ho QS, Sun H, Liew CW, Goh LP, Cheung P, Mu Y, Lescar J, Liang ZX (2009) , Structure and catalytic mechanism of the thioesterase CalE7 in enediyne biosynthesis , Journal of Biological Chemistry, ,284,23,15739-15749.
4 Qureshi IA, Ferron F, Seh CC, Cheung P, Lescar J (2009) , Crystallographic structure of ubiquitin in complex with cadmium ions , BMC Research Notes, ,2,,251.
3 Qureshi IA, Dash PK, Srivastava PS, Koundal KR (2007) , Isolation and characterization of a lectin gene from seeds of chickpea (Cicer arietinum L.) , DNA Sequence , ,18,3,196-202.
2 Qureshi IA, Dash P, Srivastava PS, Koundal KR (2006) , Purification and characterization of an N-acetyl-D-galactosamine-specific lectin from seeds of chickpea (Cicer arietinum L.) , Phytochemical Analysis , ,17,5,350-356.
1 Qureshi IA, Sethi DK, Salunke DM (2006) , Purification, identification and preliminary crystallographic studies of an allergenic protein from Lathyrus sativus. , Acta Crystallography F , ,62,,869-872.
Title Year Duration Amount(In Lakhs) PI/I
Comprehensive proteomics approach to characterize the leishmanial proteins as targets for novel therapeutics 2023 3 5900000 Insaf Ahmed Qureshi
Evaluation of M32 metallocarboxypeptidases for the development of therapeutics against leishmanial parasites 2021 3 4950000 Insaf Ahmed Qureshi
In vivo validation of membrane acid phosphatase as a vaccine candidate against leishmanial parasites 2020 3 3050000 Insaf Ahmed Qureshi
Structural and functional studies of glucose 6-phosphate dehydrogenase and 6-phosphogluconate dehydrogenase to understand their role in leishmaniasis 2018 3 4030000 Insaf Ahmed Qureshi
Understanding the role of aminopeptidases in leishmaniasis through structural and functional studies 2017 3 200000 Insaf Ahmed Qureshi
Elucidate the biochemical role of Protein-Protein interaction in the post-transcriptional regulations 2015 1 3500000 Insaf Ahmed Qureshi
Expression, purification and crystallographic studies of protein kinases from Plasmodium falciparum 2012 3 2490000 Insaf Ahmed Qureshi
Identification, purification and characterization of protein phosphatases PP1 from Leishmania donovani 2012 3 740000 Insaf Ahmed Qureshi
Crystallographic study of casein kinase as structural-based target against malaria 2012 1 300000 Insaf Ahmed Qureshi