Faculty
Faculty Details
Faculty Details
Contact info: stetali@uohyd.ac.in (or) saradakanakgiri@gmail.com
Research Interest and Professional Experience
Prof. Tetali has more than thirty (30) years of experience in research and development. She has worked in several areas of Biology, including Metabolomics of medicinal and spice plants and their Pharmacological activities against cardiovascular diseases, human clinical nutrition- postprandial state and cardio-vascular Inflammation, Micro-Algal biotechnology towards improved photosynthetic efficiency and biomass production.
Prof. Sarada D. Tetali’s research group is engaged in investigating and identifying bioactive principles of those medicinal plants have been traditionally used for cardiovascular system disorders and diseases, using human cell culture (eg. Human monocytic and aortic endothelial cells) systems modeling inflammation and oxidative stress. These cell culture models are also being used to screen for toxicity of biomolecules and/or nanomaterials used in developing health care technology. Prof. Tetali’s group is working towards enhanced production of bioactive metabolites using microbial technologies.
Molecular mechanism of herbal medicine in attenuating vascular inflammation is of great interest. It is well established that inflammation in the blood vessel walls sets the stage for the development of atherosclerosis, a blood vessel wall disease in which plaque builds up inside arteries. Arteries are blood vessels that carry oxygen-rich blood to heart and other parts of the body. Atherosclerotic cardiovascular disease is a multifactorial disease and is the most common cause for the morbidity and death in the world. Though the pharmacological industries are advancing in preventing and curing the disease, vascular disease remains as the most costly disease in terms of lives and money. Herbal medicines, those are historically known to be atheroprotective need attention in terms of understanding their molecular mechanism of action and identification of active chemical constituents. Such studies pave a way for their integration into the modern medicine.
In contrast to most modern medicine, herbal medicines contain multiple active ingredients, possibly having multiple targets in the body and thus can have potential solutions for addressing multifactorial diseases. Hence, metabolomics of herbal extracts, which are being used for cardiac health in traditional medicine, yield valuable information in designing new drugs for complexed diseases like cardio vascular diseases.
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Students/Projects Trainees
| Name | Joined As | Contact | |
|---|---|---|---|
| Nanda Gopal | Project student | thisisnandagopal@gmail.com | 6383531629 |
| Satyabrata Acharya | Ph.D. Scholar | satyabrataacharya79@gmail.com | 7504134996 |
| Aditya Ankari | Ph.D. Scholar | adityaankari@gmail.com | 9763992474 |
| Smruti Ranjan Das | Ph.D. Scholar | smrutiranjandas1996@gmail.com | 9438329844 |
| Uday Singh | Project student | udaysingh10098@gmail.com | 7982328450 |
Former Students/Projects Trainees
| Name | Joined As | Working |
|---|---|---|
| Mohd Kazim | Project student | |
| Ritwika Mohinta | Project student | |
| Praveen Kumar Kokkiripati | PhD student | BIACORE Sales Application Specialist, CYTIVA, Hyderabad, India |
| Sudhansu Sekhar Choudhury | PhD student | Deputy Manager, M/s Virchow Biotech Pvt. Ltd. Survey No.172 part, Gagillapur Hyderabad, India |
| Reddi Kiran Kumar | PhD student | Post doctoral research associate, Department of Biochemistry and Molecular Genetics, Heersink School of medicine, Hugh Kaul Human Genetics building, Kaul 560 University of Alabama Alabama, Birmingham-35205 |
| 25 | Annapoorna R.Sapuri-Butti, Limin Wang, Sarada D.Tetali, John C. Rutledge Atul N.Parikh (2021) , Interactions of different lipoproteins with supported phospholipid raft membrane (SPRM) patterns to understand similar in-vivo processes , Biochimica et Biophysica Acta (BBA) - Biomembranes, Elsevier,1863,, IF - 3.747. |
| 24 | Poonam Kulyal, Satyabrata Acharya†, Aditya B. Ankari†, Praveen K. Kokkiripati, Sarada D. Tetali, Agepati S. Raghavendra (2021) , Variable Secondary Metabolite Profiles Across Cultivars of Curcuma longa L. and C. aromatica Salisb. , Frontiers in Pharmacology, Frontiers Media S.A.,12,659546, IF - 5.75. |
| 23 | Kiran Kumar Reddi, Sarada D Tetali (2019) , Dry leaf extracts of Tinospora cordifolia (Willd.) Miers attenuate oxidative stress and inflammatory condition in human monocytic (THP-1) cells , Phytomedicine, Elsevier,61,61,152831 IF - 4.18. |
| 22 | Reddi K. Kumar, Matthias Heuchel, Karl Kratz, Andreas Lendleinb, Joachim Jankowskid, and Sarada D. Tetali (2018) , Effects of extracts prepared from modified porous poly(ether imide) microparticulate absorbers on cytotoxicity, macrophage differentiation and proinflammatory behavior of human monocytic (THP-1) cells , Clinical Hemorheology and Microcirculation, IOS Press Content Library,69,1-2,175-185 IF - 1.642. |
| 21 | Soundappan S. Mohanraj , Sarada D. Tetali , Nalini Mallikarjuna , Aparna Dutta-Gupta , Kollipara Padmasree (2018) , Biochemical properties of a bacterially-expressed Bowman-Birk inhibitor from Rhynchosia sublobata (Schumach.) Meikle seeds and its activity against gut proteases of Achaea janata , Phytomedicine, Elsevier,151,,78-90 IF - 4.18. |
| 20 | Pulok K. Mukherjee, Ranjit K. Harwansh, Shiv Bahadur, Sayan Biswas, Lalitha N. Kuchibhatla, Sarada D. Tetali and A. S. Raghavendra (2016) , Metabolomics of Medicinal Plants - A Versatile Tool for Standardization of Herbal Products and Quality Evaluation of Ayurvedic Formulations , Current science, Indian Academy of Sciences,111,10,1624-1630 IF - 0.756. |
| 19 | Poonam Kulyal, Lalitha N. Kuchibhatla, K. Uma Maheshwari, K. Nirmal Babu, Sarada D. Tetali and Agepati S. Raghavendra (2016) , Highly sensitive HPLC method for estimation of total or individual curcuminoids in Curcuma cultivars and commercial turmeric powders. , current sciences, Indian academy of sciences,111,11,1816-1824 IF - 0.756. |
| 18 | Abhaypratap Vishwakarma, Ahan Dalal, Sarada Devi Tetali, Pulugurtha Bharadwaja Kirti and Kollipara Padmasree (2016) , Genetic engineering of AtAOX1a in Saccharomyces cerevisiae prevents oxidative damage and maintains redox homeostasis , FEBS Open Bio, John Wiley ,6,2,135-146 IF - 2.101. |
| 17 | Reddi K. Kumar, Sayantani Basu, Horst-Dieter Lemke, Joachim Jankowski, Karl Kratz, Andreas Lendlein and Sarada D. Tetali (2016) , Influence of nanoporous poly(ether imide) particle extracts on human aortic endothelial cells (HAECs) , Clinical Hemorheology and Microcirculation, IOS Press Content Library,64,4,931-940 IF - 1.642. |
| 16 | Sarada D. Tetalia, Vera Jankowski, Karola Luetzow, Karl Kratzc, Andreas Lendlein and Joachim Jankowski (2016) , Adsorption capacity of poly(ether imide) microparticles to uremic toxins , Clinical hemorheology and microcirculation, IOS Press Content Library,61,4,657-665 IF - 1.642. |
| 15 | Reddi K. Kumar, Sayantani Basu, Horst-Dieter Lemke, Joachim Jankowski, Karl Kratz, Andreas Lendlein and Sarada D. Tetali (2016) , Effect of extracts of poly(ether imide) microparticles on cytotoxicity, ROS generation and proinflammatory effects on human monocytic (THP-1) cells , Clinical hemorheology and microcirculation, IOS Press Content Library,61,4,667-680 IF - 1.642. |
| 14 | Abhaypratap Vishwakarma, Sarada Devi Tetali, Jennifer Selinski, Renate Scheibe and Kollipara Padmasree (2015) , Importance of the alternative oxidase (AOX) pathway in regulating cellular redox and ROS homeostasis to optimize photosynthesis during restriction of the cytochrome oxidase , Annals of Botany, Oxford University Press,116,4,555-563 IF - 4.041. |
| 13 | Sudhansu S. Choudhury , Leena Bashyam , Nalini Manthapuram, Prasanth Bitla , Padmasree Kollipara , Sarada D. Tetali (2014) , Ocimum sanctum leaf extracts attenuate human monocytic (THP-1) cell activation , Journal of Ethnopharmacology, Elsevier,154,1,148-155 IF - 3.414. |
| 12 | Amparo C Villablanca, Sarada Tetali , Robin Altman , Kenneth F Ng and John C Rutledge (2013) , Testosterone-derived estradiol production by male endothelium is robust and dependent on p450 aromatase via estrogen receptor alpha. , Springer, ,,,. |
| 11 | Kokkiripati PK, Kamsala RV, Bashyam L, Manthapuram N, Bitla P, Peddada V, Raghavendra AS, Tetali SD (2013) , Stem-bark of Terminalia arjuna attenuates human monocytic (THP-1) and aortic endothelial cell activation , Journal of Ethnopharmacology, Elsevier,146,2,456-464 IF - 3.115. |
| 10 | den Hartigh LJ, Altman R, Hutchinson R, Petrlova J, Budamagunta MS, Tetali SD, Lagerstedt JO, Voss JC, Rutledge JC (2012) , Postprandial apoE isoform and conformational changes associated with VLDL lipolysis products modulate monocyte inflammation , Plos one, PLOS,7,11, IF - 2.776. |
| 9 | Kokkiripati PK, Bhakshu LM, Marri S, Padmasree K, Row AT, Raghavendra AS, Tetali SD (2011) , Gum resin of Boswellia serrata inhibited human monocytic (THP-1) cell activation and platelet aggregation , Journal of Ethnopharmacolgy, Elsevier,137,1,893-301 IF - 3.115. |
| 8 | Tetali SD, Budamagunta MS, Simion C, Hatters DM, Higgins LJ, Weisgraber KH, Voss JC and Rutledge, JC, MD (2010) , VLDL lipolysis products increase VLDL fluidity and convert apolipoprotein E4 into a more expanded conformation , Journal of LIpid Research, ASBMB,51,,1273-1283 IF - 4.505. |
| 7 | Mullick AE, Powers AF, Kota RS, Tetali SD, Eiserich JP, Rutledge JC (2007) , Apolipoprotein E3- and nitric oxide-dependent modulation of endothelial cell inflammatory responses , Arteriosclerosis Thrombosis Vascular Biology (ATVB), AHA Journal,27,2,339-345 IF - 6.607. |
| 6 | Tetali, S. D., M. Mitra and A. Melis (2007) , Development of the light-harvesting chlorophyll antenna in the green alga Chlamydomonas reinhardtii is regulated by the novel Tla1 gene. , Planta, Springer link,225,,813-829 IF - 3.347. |
| 5 | Tetali, S. D., M. S. Budamagunta, J. C. Voss and J. C. Rutledge (2006) , . C-terminal interactions of apolipoprotein E4 respond to the postprandial state , Journal of Lipid Research, ASBMB,47,,1358-1365 IF - 4.505. |
| 4 | Nakamura, Y., S. Kanakagiri, K. Van, W. He and M. H. Spalding (2005) , Disruption of a glycolate dehydrogenase gene in a high-CO2-requiring mutant of Chlamydomonas reinhardtii , Canadian Journal of Botany, Canadian Science Publishing,83,7,820-833 IF - 1.178. |
| 3 | Posewitz, M. C., S. L. Smolinski, S. Kanakagiri, A. Melis, M. Seibert and M. L. Ghirardi (2004) , Hydrogen photoproduction is attenuated by disruption of an isoamylase gene in Chlamydomonas reinhardtii , The Plant Cell, ASPB,16,8,2151-2163 IF - 8.631. |
| 2 | Polle, J. E., S. D. Kanakagiri and A. Melis. tla (2003) , tla1, a DNA insertional transformant of the green alga Chlamydomonas reinhardtii with a truncated light-harvesting chlorophyll antenna size. , Planta, Springer link,217,,49-59 IF - 3.347. |
| 1 | Polle, J. E., S. D. Kanakagiri and A. Melis. tla (2003) , tla1, a DNA insertional transformant of the green alga Chlamydomonas reinhardtii with a truncated light-harvesting chlorophyll antenna size. , Planta, Springer link,217,,49-59 IF - 3.347. |
| Title | Year | Duration | Amount(In Lakhs) | PI/I |
|---|---|---|---|---|
| The role of bioactive secondary metabolites from the medicinal plants Terminali arjuna (Roxb.) Wight | 2021 | 3 | 499900000000 | PI |
| Immuno-phenotyping of human aortic endothelial cells and monocytes to study antiatherogenic activity of Boerhaavia diffusa and Hemidesmus indicus | 2012 | 3 | 173000000000 | PI |
| Development, characterisation and validation of nanoparticles for the adsorption of hydrophobic , characterisation uremic toxins in renal failure patients (NPORE) | 2012 | 3 | 1555400000000 | PI |
| Purification and Characterization of Boswellic Acids and their Derivatives from the Gum Resin of Boswellia serrata (Burseraceae) using Bioassay Guided Fractionation and TOF-MS | 2012 | 3 | 234200000000 | PI |
| Effect of Terminalia arjuna’s bark extract on cytokine induced activation of human aortic endothelial cells | 2010 | 3 | 89500000000 | PI |
| Metabolite library of Curcuma longa L. and C. aromatica: variability in cultivars | 2010 | 3 | 844900000000 | co-PI |
| Phytomedicine for Vascular Inflammation: Effect of Leaf Extracts of Ocimum sanctum and Gum Resin of Boswellia serrata on Vascular Cell Inflammation | 2008 | 3 | 212700000000 | PI |