Faculty Details

Faculty Details

  • Name: Dr. Manjari Kiran
  • Mail: manjari.hcuuohyd.ac.in
  • Contact:
  • Area Of Research:Cancer Genomics; Network Biology; Machine learning; Non-coding RNAs

I am interested in applying computational approaches in understanding biology and human disease. I received my PhD training at CDFD Hyderabad during where I defined a novel dichotomy of hubs in human protein interaction networks. I also constructed a drug-target interaction network explaining the relation between side effects of drugs due to specific position of their targets in tissue specific interactions. During my post doctoral training, I used machine learning approaches for defining prognostic set of long non coding RNAs to predict outcome in glioma patients. Additionally, I used publicly available as well as in house generated RNA sequencing data to formulate hypothesis and validate findings for various biological problems.

In my current position at Hyderabad University, I intend to use my computational skills in addressing the role of long non-coding RNAs in cancers. I am also looking at the possibility of integrating interaction networks and NGS data to facilitate diagnosis and treatment regimens of cancer patients.

CV : Download CV

Title Details
R programming

Elective course

Students/Projects Trainees

Name Joined As Mail Contact
Mr. Shyam Venkatadri MSc student project trainee shyamuohyd@gmail.com ---
Ms. Anubha Dey PhD student anubha.123034@gmail.com ---

Former Students/Projects Trainees

Name Joined As Working
Jeevan Gochhayat KVPY Summer Project Fellow Centre for excellence in basic Sciences, DAE, Mumbai
17 Saha, Shekhar., Kiran, Manjari., Kuscu, Canan., Chatrath, Ajay., Wotton, David., Mayo, Marty W., Dutta, Anindya., (2020) , Long noncoding RNA DRAIC inhibits prostate cancer progression by interacting with IKK to inhibit NF-κB activation , Cancer Research, American Association for Cancer Research,,,.
16 Chatrath, Ajay., Przanowska, Roza., Kiran, Shashi., Su, Zhangli., Saha, Shekhar., Wilson, Briana., Tsunematsu, Takaaki., Ahn, Ji-Hye., Lee, Kyung Yong., Paulsen, Teressa., (2020) , The pan-cancer landscape of prognostic germline variants in 10,582 patients , Genome Medicine, BioMed Central,12,1,1-18.
15 Kiran, Manjari., Chatrath, Ajay., Tang, Xiwei., Keenan, Daniel Macrae., Dutta, Anindya., (2019) , A prognostic signature for lower grade gliomas based on expression of long non-coding RNAs , Molecular neurobiology, Springer US,56,7,4786-4798.
14 Chatrath, Ajay., Kiran, Manjari., Kumar, Pankaj., Ratan, Aakrosh., Dutta, Anindya., (2019) , The Germline Variants rs61757955 and rs34988193 Are Predictive of Survival in Lower Grade Glioma Patients , Molecular Cancer Research, American Association for Cancer Research,17,5,1075-1086.
13 Kiran, Manjari., (2018) , Role of a Novel Family of Short RNAs, tRFs, in Prostate Cancer , , VIRGINIA UNIV CHARLOTTESVILLE CHARLOTTESVILLE United States,,,.
12 Kuscu, Canan., Kumar, Pankaj., Kiran, Manjari., Su, Zhangli., Malik, Asrar., Dutta, Anindya., (2018) , tRNA fragments (tRFs) guide Ago to regulate gene expression post-transcriptionally in a Dicer-independent manner , Rna, Cold Spring Harbor Lab,24,8,1093-1105.
11 Reon, Brian J., Karia, Bruno Takao Real., Kiran, Manjari., Dutta, Anindya., (2018) , LINC00152 promotes invasion through a 3′-hairpin structure and associates with prognosis in glioblastoma , Molecular Cancer Research, American Association for Cancer Research,16,10,1470-1482.
10 Cichewicz, Magdalena A., Kiran, Manjari., Przanowska, Róża K., Sobierajska, Ewelina., Shibata, Yoshiyuki., Dutta, Anindya., (2018) , MUNC, an enhancer RNA upstream from the MYOD gene, induces a subgroup of myogenic transcripts in trans independently of MyoD , Molecular and Cellular Biology, American Society for Microbiology Journals,38,20,e00655-17.
9 Dutta, Anindya., Kumar, Pankaj., Kiran, Manjari., Kuscu, Canan., (2016) , Transfer RNA Fragments (tRFs): a Novel Class of Non-micro Short RNAs that Uses Ago1, 3 and 4 to Repress Specific Target RNAs Through 5′ Seed Sequences , The FASEB Journal, The Federation of American Societies for Experimental Biology,30,1_supplement,1054.5-1054.5.
8 Kiran, M., Nagarajaram, HA., (2016) , Interaction and localization diversities of global and local hubs in human protein–protein interaction networks , Molecular BioSystems, Royal Society of Chemistry,12,9,2875-2882.
7 Shibata, Etsuko., Kiran, Manjari., Shibata, Yoshiyuki., Singh, Samarendra., Kiran, Shashi., Dutta, Anindya., (2016) , Two subunits of human ORC are dispensable for DNA replication and proliferation , Elife, eLife Sciences Publications Limited,5,,e19084.
6 Kiran, Shashi., Anwar, Tarique., Kiran, Manjari., Ramakrishna, Gayatri., (2015) , Sirtuin 7 in cell proliferation, stress and disease: Rise of the Seventh Sirtuin! , Cellular signalling, Pergamon,27,3,673-682.
5 Bashyam, Murali D., Chaudhary, Ajay K., Kiran, Manjari., Nagarajaram, Hampapathalu A., Devi, Radha Rama., Ranganath, Prajnya., Dalal, Ashwin., Bashyam, Leena., Gupta, Neerja., Kabra, Madhulika., (2014) , Splice, insertion‐deletion and nonsense mutations that perturb the phenylalanine hydroxylase transcript cause phenylketonuria in India , Journal of cellular biochemistry, ,115,3,566-574.
4 Bashyam, Murali D., Chaudhary, Ajay K., Kiran, Manjari., Reddy, Venkat., Nagarajaram, Hampapathalu A., Dalal, Ashwin., Bashyam, Leena., Suri, Deepti., Gupta, Anju., Gupta, Neerja., (2014) , Molecular analyses of novel ASAH1 mutations causing Farber lipogranulomatosis: analyses of exonic splicing enhancer inactivating mutation , Clinical genetics, Blackwell Publishing Ltd Oxford, UK,86,6,530-538.
3 Manjari, Kiran., (2014) , Local and global hubs in human protein protein interaction network , , Manipal,,,.
2 Kiran, Manjari., Nagarajaram, Hampapathalu Adimurthy., (2013) , Global versus local hubs in human protein–protein interaction network , Journal of proteome research, American Chemical Society,12,12,5436-5446.
1 Bashyam, Murali D., Chaudhary, Ajay K., Sinha, Manjari., Nagarajaram, HA., Devi, A Radha Rama., Bashyam, Leena., Reddy, E Chandrakanth., Dalal, Ashwin., (2012) , Molecular genetic analysis of MSUD from India reveals mutations causing altered protein truncation affecting the C‐termini of E1α and E1β , Journal of cellular biochemistry, Wiley Subscription Services, Inc., A Wiley Company Hoboken,113,10,3122-3132.

Jan 2019-May 2019    Semester VIII: SB452 Computational systems biology : Network Biology (Theory + Practical = 2.5 credits)

                                    Semester IV: SB253 Evolution and Diversity (Theory = 1 credit)

July 2019-Nov 2019   Semester VII: SB403 Bioinformatics  (Theory + Practical = 5 Credits)

Jan 2020-May 2020    Semester VI: R programming (Practical = 2 credits)

                                    Semester VIII: Genomics: small RNA (2 credits)

My immediate interest lies in

  • Identification of Prognostic Signature in Cancers
  • Unraveling the role of Long non-coding RNAs in Cancers
  • Non-cancer drug repurposition
  • Postdoctoral fellow, Department of Biochemistry and Molecular Genetics, University of Virginia, USA

  • PhD in Computational Biology, CDFD, Manipal University, Hyderabad, India.

  • Masters in Bioinformatics, Banaras Hindu University (BHU), India

  • Bachelors in Zoology (Hons.), BHU, India
  • Travel Award, 2017: RNA Society of North Carolina to attend and present my work in the symposium on RNA Biology XII: RNA Tool and Target, University of North Carolina at Chapel Hill.

  • DoD Postdoctoral Training Award, 2016: 2 years Postdoctoral training award in prostate cancer from Department of Defense Congressionally Directed Medical Research Programs (DoD-CDMRP), U.S. Army Medical Research and Materiel Command (MCMR-CD). USA.

  • Travel Grant, 2013: Centre for DNA Fingerprinting and Diagnostics to attend and present my work in the ISMB/ECCB 2013, Berlin, Germany.

  • CSIR Research Fellowship, 2008: Council of Scientific and Industrial Research (CSIR), Govt. of India for pursuing research as a PhD student in India.