Dr. Manjari Kiran is a computational biologist. She uses publicly available biological data to address fundamental questions in biology and generate data based models. She did her PhD with Prof. H. A. Nagarajaram at CDFD, Hyderabad. In her PhD, she proposed a novel dichotomy of highly connected proteins (Global and Local hubs) using human tissue-specific protein-protein interaction network.(Kiran and Nagarajaram, 2013, Journal of Proteome Res; Kiran and Nagarajaram, 2016, Mol Biosystems).
After that she went on to work as research associate with Prof. Anindya Dutta, University of Virginia. There she identified a set of 8 long non-coding RNAs (UVa-8) whose combined expression can predict survival in glioma patients (Kiran et al, 2018, Mol Neurobiology). Her work on prostate cancer specific tRNA-derived fragments as a prognostic marker and their role in prostate cancer metastasis was funded by Department of Defense (DoD) for two years of postdoctoral training. Apart from these, she has worked on several collaborative projects involving novel long non-coding RNAs (lncRNAs) in cancers (CYTOR and DRAIC) and muscle differentiation (MUNC) (Reon et al, 2018,Mol Can Res; Cichewicz et al, 2018, Mol Cel Bio; Saha et al, 2020, Cancer Res, Kuscu et al, 2018, RNA) and mapping of human origin of replication (Shibata et al, 2016, eLife).
In her current position at University of Hyderabad apart from teaching Bioinformatics, R programming and Network biology, she is interested in cancer genomics, non-coding RNAs, network based approaches in drug repurposition and machine learning to develop tools.
- Travel Award, 2017: RNA Society of North Carolina to attend and present my work in the symposium on RNA Biology XII: RNA Tool and Target, University of North Carolina at Chapel Hill.
- DoD Postdoctoral Training Award, 2016: 2 years Postdoctoral training award in prostate cancer from Department of Defense Congressionally Directed Medical Research Programs (DoD-CDMRP), U.S. Army Medical Research and Materiel Command (MCMR-CD). USA.
- Travel Grant, 2013: Centre for DNA Fingerprinting and Diagnostics to attend and present my work in the ISMB/ECCB 2013, Berlin, Germany.
- CSIR Research Fellowship, 2008: Council of Scientific and Industrial Research (CSIR), Govt. of India for pursuing research as a PhD student in India.
Computational systems biology : Network Biology (Practical)
Bioinformatics (Theory + Practical)
R programming (Practical)
Genomics: small RNA (Theory + Practical)
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Former Students/Projects Trainees
|Mr. Shyam Venkatadri||MSc student project trainee|
|Mr. Jeevan Gochhayat||KVPY Summer Project Fellow||PhD Student @IISER, Pune, India|
|Mr. Sarthak Satpathy||Master's Project Trainee||PhD student at Emory University, Georgia, USA|
|Ms. Surabhi Kavya Sri||Master's Project Trainee||Tata Consultancy Services, Hyderabad|
|Mr. Haneesh Jindal||SERB - Project JRF||Project JRF @University of Hyderabad, Hyderabad, India|
|Ms. Gayathri R||Master's Project Trainee||PhD Student @National Institute of Virology, Pune, India|
|Ms Koushiki Basu||Master's Project Trainee||PhD student @Purdue University, USA|
|Ms Arunima Chaudhary||Master's Project Trainee||PhD student @Saha Institute of Nuclear Physics, Kolkata, India|
|29||Nithya, C., Manjari Kiran and H.A.Nagarajaram (2024) , Hubs and Bottlenecks in Protein-Protein Interaction Networks , In: Mandal, S. (eds) Reverse Engineering of Regulatory Networks. Methods Molecular Biology, (doi.org/10.1007/978-1-0716-3461-5_13), Springer-Nature,2719,,.|
|28||Nithya, Chandramohan., Kiran, Manjari., Nagarajaram, Hampapathalu Adimurthy., (2023) , Dissection of hubs and bottlenecks in a protein-protein interaction network , Computational Biology and Chemistry, Elsevier,102,,107802 IF - 3.737.|
|27||Nithya, Chandramohan., Kiran, Manjari., Nagarajaram, Hampapathalu Adimurthy., (2023) , Dissection of hubs and bottlenecks in a protein-protein interaction network , Computational Biology and Chemistry, Elsevier,102,,107802.|
|26||Basu, Koushiki., Dey, Anubha., Kiran, Manjari., (2023) , Inefficient splicing of long non-coding RNAs is associated with higher transcript complexity in human and mouse , RNA biology, Taylor & Francis,20,1,563-572.|
|25||Nithya, Chandramohan., Kiran, Manjari., Nagarajaram, Hampapathalu Adimurthy., (2021) , Comparative analysis of Pure Hubs and Pure Bottlenecks in Human Protein-protein Interaction Networks , bioRxiv, Cold Spring Harbor Laboratory,,,2021.04. 06.438602.|
|24||Namwanje, Maria., Bisunke, Bijay., Rousselle, Thomas V., Lamanilao, Gene G., Sunder, Venkatadri S., Patterson, Elizabeth C., Kuscu, Canan., Kuscu, Cem., Maluf, Daniel., Kiran, Manjari., (2021) , Rapamycin alternatively modifies mitochondrial dynamics in dendritic cells to reduce kidney ischemic reperfusion injury , International Journal of Molecular Sciences, MDPI,22,10,5386.|
|23||Kuscu, Canan., Kiran, Manjari., Mohammed, Akram., Kuscu, Cem., Satpathy, Sarthak., Wolen, Aaron., Bardhi, Elissa., Bajwa, Amandeep., Eason, James D., Maluf, Daniel., (2021) , Integrative analyses of circulating small RNAs and kidney graft transcriptome in transplant glomerulopathy , International Journal of Molecular Sciences, MDPI,22,12,6218.|
|22||Saha, Shekhar., Kiran, Manjari., Kuscu, Canan., Chatrath, Ajay., Wotton, David., Mayo, Marty W., Dutta, Anindya., (2020) , Long noncoding RNA DRAIC inhibits prostate cancer progression by interacting with IKK to inhibit NF-κB activation , Cancer research, American Association for Cancer Research,80,5,950-963.|
|21||Chatrath, Ajay., Przanowska, Roza., Kiran, Shashi., Su, Zhangli., Saha, Shekhar., Wilson, Briana., Tsunematsu, Takaaki., Ahn, Ji-Hye., Lee, Kyung Yong., Paulsen, Teressa., (2020) , The pan-cancer landscape of prognostic germline variants in 10,582 patients , Genome medicine, BioMed Central,12,,1-18.|
|20||Kiran, Shashi., Kiran, Manjari., Ramakrishna, Gayatri., (2020) , Sirtuin 7 Promotes Mesenchymal to Epithelial Transition by β-Catenin Redistribution and Stabilization , Frontiers in Oncology, Frontiers Media SA,10,,740.|
|19||Chakrabarti, Sankha S., Sunder, Venkatadri S., Kaur, Upinder., Bala, Sapna., Sharma, Priyanka., Kiran, Manjari., Rawal, Ravindra K., Chakrabarti, Sasanka., (2020) , Identifying the mechanisms of α-synuclein-mediated cytotoxicity in Parkinson’s disease: new insights from a bioinformatics-based approach , Future Neurology, Future Medicine Ltd London, UK,15,3,FNL49.|
|18||Kuscu, C., Kiran, M., Wolen, A., Kuscu, C., Bajwa, A., Eason, J., Maluf, D., Akalin, E., Mas, V., (2020) , Transcriptomic Profiling of Paired Serum and Biopsy Samples from FSGS Patients , AMERICAN JOURNAL OF TRANSPLANTATION, WILEY 111 RIVER ST, HOBOKEN 07030-5774, NJ USA,20,,643-643.|
|17||Lande, Kashmiri., Gupta, Jitesh., Ranjan, Ravi., Kiran, Manjari., Torres Solis, Luis Fernando., Solís Herrera, Arturo., Aliev, Gjumrakch., Karnati, Roy., (2020) , Exosomes: Insights from retinoblastoma and other eye cancers , International Journal of Molecular Sciences, MDPI,21,19,7055.|
|16||Kiran, Manjari., Chatrath, Ajay., Tang, Xiwei., Keenan, Daniel Macrae., Dutta, Anindya., (2019) , A prognostic signature for lower grade gliomas based on expression of long non-coding RNAs , Molecular neurobiology, Springer US,56,,4786-4798.|
|15||Chatrath, Ajay., Kiran, Manjari., Kumar, Pankaj., Ratan, Aakrosh., Dutta, Anindya., (2019) , The germline variants rs61757955 and rs34988193 are predictive of survival in lower grade glioma patients , Molecular Cancer Research, American Association for Cancer Research,17,5,1075-1086.|
|14||Kuscu, Canan., Kumar, Pankaj., Kiran, Manjari., Su, Zhangli., Malik, Asrar., Dutta, Anindya., (2018) , tRNA fragments (tRFs) guide Ago to regulate gene expression post-transcriptionally in a Dicer-independent manner , Rna, Cold Spring Harbor Lab,24,8,1093-1105.|
|13||Reon, Brian J., Takao Real Karia, Bruno., Kiran, Manjari., Dutta, Anindya., (2018) , LINC00152 promotes invasion through a 3′-hairpin structure and associates with prognosis in glioblastoma , Molecular Cancer Research, American Association for Cancer Research,16,10,1470-1482.|
|12||Cichewicz, Magdalena A., Kiran, Manjari., Przanowska, Róża K., Sobierajska, Ewelina., Shibata, Yoshiyuki., Dutta, Anindya., (2018) , MUNC, an enhancer RNA upstream from the MYOD gene, induces a subgroup of myogenic transcripts in trans independently of MyoD , Molecular and Cellular Biology, Taylor & Francis,38,20,e00655-17.|
|11||Kiran, Manjari., RECTOR and VISITORS OF THE UNIVERSITY CHARLOTTESVILE CHARLOTTESVILLE United States., (2017) , Role of a Novel Family of Short RNAs, tRFs, in Prostate Cancer , , ,,,.|
|10||Dutta, Anindya., Kumar, Pankaj., Kiran, Manjari., Kuscu, Canan., (2016) , Transfer RNA Fragments (tRFs): a Novel Class of Non‐micro Short RNAs that Uses Ago1, 3 and 4 to Repress Specific Target RNAs Through 5′ Seed Sequences , The FASEB Journal, The Federation of American Societies for Experimental Biology,30,,1054.5-1054.5.|
|9||Kiran, M., Nagarajaram, HA., (2016) , Interaction and localization diversities of global and local hubs in human protein–protein interaction networks , Molecular BioSystems, Royal Society of Chemistry,12,9,2875-2882.|
|8||Shibata, Etsuko., Kiran, Manjari., Shibata, Yoshiyuki., Singh, Samarendra., Kiran, Shashi., Dutta, Anindya., (2016) , Two subunits of human ORC are dispensable for DNA replication and proliferation , Elife, eLife Sciences Publications, Ltd,5,,e19084.|
|7||Kiran, Shashi., Anwar, Tarique., Kiran, Manjari., Ramakrishna, Gayatri., (2015) , Sirtuin 7 in cell proliferation, stress and disease: Rise of the Seventh Sirtuin! , Cellular signalling, Pergamon,27,3,673-682.|
|6||Bashyam, Murali D., Chaudhary, Ajay K., Kiran, Manjari., Nagarajaram, Hampapathalu A., Devi, Radha Rama., Ranganath, Prajnya., Dalal, Ashwin., Bashyam, Leena., Gupta, Neerja., Kabra, Madhulika., (2014) , Splice, insertion‐deletion and nonsense mutations that perturb the phenylalanine hydroxylase transcript cause phenylketonuria in India , Journal of Cellular Biochemistry, ,115,3,566-574.|
|5||Bashyam, Murali D., Chaudhary, Ajay K., Kiran, Manjari., Reddy, Venkat., Nagarajaram, Hampapathalu A., Dalal, Ashwin., Bashyam, Leena., Suri, Deepti., Gupta, Anju., Gupta, Neerja., (2014) , Molecular analyses of novel ASAH1 mutations causing Farber lipogranulomatosis: analyses of exonic splicing enhancer inactivating mutation , Clinical genetics, Blackwell Publishing Ltd Oxford, UK,86,6,530-538.|
|4||Kiran, Manjari., Nagarajaram, Hampapathalu Adimurthy., (2013) , Global versus local hubs in human protein–protein interaction network , Journal of Proteome Research, American Chemical Society,12,12,5436-5446.|
|3||Bashyam, Murali D., Chaudhary, Ajay K., Sinha, Manjari., Nagarajaram, HA., Devi, A Radha Rama., Bashyam, Leena., Reddy, E Chandrakanth., Dalal, Ashwin., (2012) , Molecular genetic analysis of MSUD from India reveals mutations causing altered protein truncation affecting the C‐termini of E1α and E1β , Journal of Cellular Biochemistry, Wiley Subscription Services, Inc., A Wiley Company Hoboken,113,10,3122-3132.|
|2||Manjari, Kiran., (1977) , Local and global hubs in human protein protein interaction network , , Manipal,,,.|
|1||Kiran, Manjari., (1977) , Analysis of Tissue-Specific Protein-Protein Interaction Networks: Global versus Local Hubs , , ,,,.|
|DBT-Centre for Microbial Informatics (DBT-CMI)||2021||5||176||Prof. H.A.Nagarajaram (PI), Prof. Appa Rao Podile (Co-PI), Prof. Dayananda Siddavattam (Co-PI), Prof. Ch Venkataramana (Co-PI), Dr. Pankaj Singh (Co-PI), Dr. Vivek (Co-PI), Dr. Manjari Kiran (Co-PI)|
|A multi-omics and multi-label approach to predict genetic interactions in cancers||2021||3||25.84||Dr. Manjari Kiran|
|Identification of gender-specific prognostic genes in 27 human cancers.||2020||2||10||Dr. Manjari Kiran|
|A novel computational approach to generate genome based barcode intended to catalog Indian microbial species.||2020||5||68.6||Dr. Manjari Kiran, Dr. Pankaj S Dholaniya|
|Integrative approach to characterize human long non-coding RNAs.||2020||2||25.66||Dr. Manjari Kiran|