Faculty Details

Faculty Details

  • Name: Dr. Manjari Kiran
  • Mail: manjari.hcuuohyd.ac.in
  • Contact:
  • Area Of Research:Cancer Genomics; Network Biology; Machine learning; Non-coding RNAs


Dr. Manjari Kiran is a computational biologist. She uses publicly available biological data to address fundamental questions in biology and generate data based models. She did her PhD with Prof. H. A. Nagarajaram at CDFD, Hyderabad. In her PhD, she proposed a novel dichotomy of highly connected proteins (Global and Local hubs) using human tissue-specific protein-protein interaction network.(Kiran and Nagarajaram, 2013, Journal of Proteome Res; Kiran and Nagarajaram, 2016, Mol Biosystems). 


After that she went on to work as research associate with Prof. Anindya DuttaUniversity of VirginiaThere she identified a set of 8 long non-coding RNAs (UVa-8) whose combined expression can predict survival in glioma patients (Kiran et al, 2018, Mol Neurobiology). Her work on prostate cancer specific tRNA-derived fragments as a prognostic marker and their role in prostate cancer metastasis was funded by Department of Defense (DoD) for two years of postdoctoral training. Apart from these, she has worked on several collaborative projects involving novel long non-coding RNAs (lncRNAs) in cancers (CYTOR and DRAIC) and muscle differentiation (MUNC) (Reon et al, 2018,Mol Can Res; Cichewicz et al, 2018, Mol Cel Bio; Saha et al, 2020, Cancer ResKuscu et al, 2018, RNA) and mapping of human origin of replication (Shibata et al, 2016, eLife).


In her current position at University of Hyderabad apart from teaching Bioinformatics, R programming and Network biology, she is interested in cancer genomics, non-coding RNAs, network based approaches in drug repurposition and machine learning to develop tools.


Awards
  • Travel Award, 2017: RNA Society of North Carolina to attend and present my work in the symposium on RNA Biology XII: RNA Tool and Target, University of North Carolina at Chapel Hill.
  • DoD Postdoctoral Training Award, 2016: 2 years Postdoctoral training award in prostate cancer from Department of Defense Congressionally Directed Medical Research Programs (DoD-CDMRP), U.S. Army Medical Research and Materiel Command (MCMR-CD). USA.
  • Travel Grant, 2013: Centre for DNA Fingerprinting and Diagnostics to attend and present my work in the ISMB/ECCB 2013, Berlin, Germany.
  • CSIR Research Fellowship, 2008: Council of Scientific and Industrial Research (CSIR), Govt. of India for pursuing research as a PhD student in India.
Education and Previous Positions
  • Postdoctoral fellow, Department of Biochemistry and Molecular Genetics, University of Virginia, USA
  • PhD in Computational Biology, CDFD, Manipal University, Hyderabad, India.
  • Masters in Bioinformatics, Banaras Hindu University (BHU), India
  • Bachelors in Zoology (Hons.), BHU, India

CV : Download CV

Title Details
SB403: Bioinformatics

Online teaching has started from 20th August 2020

Open Position

We are looking for highly motivated and interested candidate for PhD position. For more information about the PhD program, visit the University of Hyderabad PhD Program 2020

Students/Projects Trainees

Name Joined As Mail Contact
Ms. Anubha Dey PhD student 19lsph01@uohyd.ac.in ---
Mr. Sarthak Satpathy Master's Project Trainee 16ilmb15@uohyd.ac.in ---
Ms. Surabhi Kavya Sri Master's Project Trainee surabhiksri@gmail.com ---

Former Students/Projects Trainees

Name Joined As Working
Mr. Shyam Venkatadri MSc student project trainee
Mr. Jeevan Gochhayat KVPY Summer Project Fellow Centre for excellence in basic Sciences, DAE, Mumbai
19 Saha, Shekhar., Kiran, Manjari., Kuscu, Canan., Chatrath, Ajay., Wotton, David., Mayo, Marty W., Dutta, Anindya., (2020) , Long noncoding RNA DRAIC inhibits prostate cancer progression by interacting with IKK to inhibit NF-κB activation , Cancer Research, American Association for Cancer Research,80,5,950-963.
18 Chatrath, Ajay., Przanowska, Roza., Kiran, Shashi., Su, Zhangli., Saha, Shekhar., Wilson, Briana., Tsunematsu, Takaaki., Ahn, Ji-Hye., Lee, Kyung Yong., Paulsen, Teressa., (2020) , The pan-cancer landscape of prognostic germline variants in 10,582 patients , Genome medicine, BioMed Central,12,1,1-18.
17 Kiran, Shashi., Kiran, Manjari., Ramakrishna, Gayatri., (2020) , Sirtuin 7 promotes Mesenchymal to Epithelial transition by β-catenin redistribution and stabilization , Frontiers in Oncology, Frontiers,10,,740.
16 Chakrabarti, Sankha S., Sunder, Venkatadri S., Kaur, Upinder., Bala, Sapna., Sharma, Priyanka., Kiran, Manjari., Rawal, Ravindra K., Chakrabarti, Sasanka., (2020) , Identifying the mechanisms of α-synuclein-mediated cytotoxicity in Parkinson’s disease: new insights from a bioinformatics-based approach , Future Neurology, Future Medicine,,0,FNL49.
15 Kiran, Manjari., Chatrath, Ajay., Tang, Xiwei., Keenan, Daniel Macrae., Dutta, Anindya., (2019) , A prognostic signature for lower grade gliomas based on expression of long non-coding RNAs , Molecular Neurobiology, Springer US,56,7,4786-4798.
14 Chatrath, Ajay., Kiran, Manjari., Kumar, Pankaj., Ratan, Aakrosh., Dutta, Anindya., (2019) , The germline variants rs61757955 and rs34988193 are predictive of survival in lower grade glioma patients , Molecular Cancer Research, American Association for Cancer Research,17,5,1075-1086.
13 Kiran, Manjari., (2018) , Role of a Novel Family of Short RNAs, tRFs, in Prostate Cancer , , VIRGINIA UNIV CHARLOTTESVILLE CHARLOTTESVILLE United States,,,.
12 Kuscu, Canan., Kumar, Pankaj., Kiran, Manjari., Su, Zhangli., Malik, Asrar., Dutta, Anindya., (2018) , tRNA fragments (tRFs) guide Ago to regulate gene expression post-transcriptionally in a Dicer-independent manner , Rna, Cold Spring Harbor Lab,24,8,1093-1105.
11 Reon, Brian J., Karia, Bruno Takao Real., Kiran, Manjari., Dutta, Anindya., (2018) , LINC00152 promotes invasion through a 3′-hairpin structure and associates with prognosis in glioblastoma , Molecular Cancer Research, American Association for Cancer Research,16,10,1470-1482.
10 Cichewicz, Magdalena A., Kiran, Manjari., Przanowska, Róża K., Sobierajska, Ewelina., Shibata, Yoshiyuki., Dutta, Anindya., (2018) , MUNC, an enhancer RNA upstream from the MYOD gene, induces a subgroup of myogenic transcripts in trans independently of MyoD , Molecular and Cellular Biology, American Society for Microbiology Journals,38,20,.
9 Dutta, Anindya., Kumar, Pankaj., Kiran, Manjari., Kuscu, Canan., (2016) , Transfer RNA Fragments (tRFs): a Novel Class of Non-micro Short RNAs that Uses Ago1, 3 and 4 to Repress Specific Target RNAs Through 5′ Seed Sequences , The FASEB Journal, The Federation of American Societies for Experimental Biology,30,1_supplement,1054.5-1054.5.
8 Kiran, M., Nagarajaram, HA., (2016) , Interaction and localization diversities of global and local hubs in human protein–protein interaction networks , Molecular BioSystems, Royal Society of Chemistry,12,9,2875-2882.
7 Shibata, Etsuko., Kiran, Manjari., Shibata, Yoshiyuki., Singh, Samarendra., Kiran, Shashi., Dutta, Anindya., (2016) , Two subunits of human ORC are dispensable for DNA replication and proliferation , Elife, eLife Sciences Publications Limited,5,,e19084.
6 Kiran, Shashi., Anwar, Tarique., Kiran, Manjari., Ramakrishna, Gayatri., (2015) , Sirtuin 7 in cell proliferation, stress and disease: Rise of the Seventh Sirtuin! , Cellular signalling, Pergamon,27,3,673-682.
5 Bashyam, Murali D., Chaudhary, Ajay K., Kiran, Manjari., Nagarajaram, Hampapathalu A., Devi, Radha Rama., Ranganath, Prajnya., Dalal, Ashwin., Bashyam, Leena., Gupta, Neerja., Kabra, Madhulika., (2014) , Splice, insertion‐deletion and nonsense mutations that perturb the phenylalanine hydroxylase transcript cause phenylketonuria in India , Journal of Cellular Biochemistry, ,115,3,566-574.
4 Bashyam, Murali D., Chaudhary, Ajay K., Kiran, Manjari., Reddy, Venkat., Nagarajaram, Hampapathalu A., Dalal, Ashwin., Bashyam, Leena., Suri, Deepti., Gupta, Anju., Gupta, Neerja., (2014) , Molecular analyses of novel ASAH1 mutations causing Farber lipogranulomatosis: analyses of exonic splicing enhancer inactivating mutation , Clinical genetics, Blackwell Publishing Ltd Oxford, UK,86,6,530-538.
3 Kiran, Manjari., Nagarajaram, Hampapathalu Adimurthy., (2013) , Global versus local hubs in human protein–protein interaction network , Journal of Proteome Research, American Chemical Society,12,12,5436-5446.
2 Bashyam, Murali D., Chaudhary, Ajay K., Sinha, Manjari., Nagarajaram, HA., Devi, A Radha Rama., Bashyam, Leena., Reddy, E Chandrakanth., Dalal, Ashwin., (2012) , Molecular genetic analysis of MSUD from India reveals mutations causing altered protein truncation affecting the C‐termini of E1α and E1β , Journal of cellular biochemistry, Wiley Subscription Services, Inc., A Wiley Company Hoboken,113,10,3122-3132.
1 Manjari, Kiran., (1977) , Local and global hubs in human protein protein interaction network , , Manipal,,,.
Title Year Duration Amount(In Lakhs) PI/I
Identification of gender-specific prognostic genes in 27 human cancers. 2020 2 7.94 Dr. Manjari Kiran
A novel computational approach to generate genome based barcode intended to catalog Indian microbial species. 2020 5 68.6 Dr. Manjari Kiran, Dr. Pankaj S Dholaniya

Jan 2019-May 2019    Semester VIII: SB452 Computational systems biology : Network Biology (Theory + Practical = 2.5 credits)

                                    Semester IV: SB253 Evolution and Diversity (Theory = 1 credit)

July 2019-Nov 2019   Semester VII: SB403 Bioinformatics  (Theory + Practical = 5 Credits)

Jan 2020-May 2020    Semester VI: R programming (Practical = 2 credits)

                                    Semester VIII: Genomics: small RNA (2 credits)



My immediate interest lies in

  • Identification of Prognostic Signature in Cancers
  • Unraveling the role of Long non-coding RNAs in Cancers
  • Non-cancer drug repurposition

2020

2 Sep 2020: New addition to the lab

Welcome Sarthak and Surabhi !!