Faculty Details

Faculty Details

  • Name: Dr. Manjari Kiran
  • Mail: manjari.hcuuohyd.ac.in
  • Contact:
  • Area Of Research:Cancer Genomics; Network Biology; Machine learning; Non-coding RNAs

I am interested in applying computational approaches in understanding biology and human disease. I received my PhD training at CDFD Hyderabad during where I defined a novel dichotomy of hubs in human protein interaction networks. I also constructed a drug-target interaction network explaining the relation between side effects of drugs due to specific position of their targets in tissue specific interactions. During my post doctoral training, I used machine learning approaches for defining prognostic set of long non coding RNAs to predict outcome in glioma patients. Additionally, I used publicly available as well as in house generated RNA sequencing data to formulate hypothesis and validate findings for various biological problems.

In my current position at Hyderabad University, I intend to use my computational skills in addressing the role of long non-coding RNAs in cancers. I am also looking at the possibility of integrating interaction networks and NGS data to facilitate diagnosis and treatment regimens of cancer patients.

CV : Download CV

Title Details
R programming

Elective course

Students/Projects Trainees

Name Joined As Mail Contact
Mr. Shyam Venkatadri MSc student project trainee shyamuohyd@gmail.com ---
Ms. Anubha Dey PhD student anubha.123034@gmail.com ---
17 Saha, Shekhar., Kiran, Manjari., Kuscu, Canan., Chatrath, Ajay., Wotton, David., Mayo, Marty W., Dutta, Anindya., (2020) , Long noncoding RNA DRAIC inhibits prostate cancer progression by interacting with IKK to inhibit NF-κB activation , Cancer Research, American Association for Cancer Research,,,.
16 Kiran, Manjari., Chatrath, Ajay., Tang, Xiwei., Keenan, Daniel Macrae., Dutta, Anindya., (2019) , A prognostic signature for lower grade gliomas based on expression of long non-coding RNAs , Molecular neurobiology, Springer US,56,7,4786-4798.
15 Chatrath, Ajay., Kiran, Manjari., Kumar, Pankaj., Ratan, Aakrosh., Dutta, Anindya., (2019) , The Germline Variants rs61757955 and rs34988193 Are Predictive of Survival in Lower Grade Glioma Patients , Molecular Cancer Research, American Association for Cancer Research,17,5,1075-1086.
14 Chatrath, Ajay., Przanowska, Roza., Kiran, Shashi., Su, Zhangli., Saha, Shekhar., Wilson, Briana., Tsunematsu, Takaaki., Ahn, Ji-Hye., Lee, Kyung Yong., Paulsen, Teressa., (2019) , The Pan-Cancer Landscape of Prognostic Germline Variants in 10,582 Patients , medRxiv, Cold Spring Harbor Laboratory Press,,,19010264.
13 Kiran, Manjari., (2018) , Role of a Novel Family of Short RNAs, tRFs, in Prostate Cancer , , VIRGINIA UNIV CHARLOTTESVILLE CHARLOTTESVILLE United States,,,.
12 Kuscu, Canan., Kumar, Pankaj., Kiran, Manjari., Su, Zhangli., Malik, Asrar., Dutta, Anindya., (2018) , tRNA fragments (tRFs) guide Ago to regulate gene expression post-transcriptionally in a Dicer-independent manner , RNA, Cold Spring Harbor Lab,24,8,1093-1105.
11 Reon, Brian J., Karia, Bruno Takao Real., Kiran, Manjari., Dutta, Anindya., (2018) , LINC00152 promotes invasion through a 3′-hairpin structure and associates with prognosis in glioblastoma , Molecular Cancer Research, American Association for Cancer Research,16,10,1470-1482.
10 Cichewicz, Magdalena A., Kiran, Manjari., Przanowska, Róża K., Sobierajska, Ewelina., Shibata, Yoshiyuki., Dutta, Anindya., (2018) , MUNC, an enhancer RNA upstream from the MYOD gene, induces a subgroup of myogenic transcripts in trans independently of MyoD , Molecular and Cellular Biology, American Society for Microbiology Journals,38,20,e00655-17.
9 Dutta, Anindya., Kumar, Pankaj., Kiran, Manjari., Kuscu, Canan., (2016) , Transfer RNA Fragments (tRFs): a Novel Class of Non-micro Short RNAs that Uses Ago1, 3 and 4 to Repress Specific Target RNAs Through 5′ Seed Sequences , The FASEB Journal, The Federation of American Societies for Experimental Biology,30,1_supplement,1054.5-1054.5.
8 Kiran, M., Nagarajaram, HA., (2016) , Interaction and localization diversities of global and local hubs in human protein–protein interaction networks , Molecular BioSystems, Royal Society of Chemistry,12,9,2875-2882.
7 Shibata, Etsuko., Kiran, Manjari., Shibata, Yoshiyuki., Singh, Samarendra., Kiran, Shashi., Dutta, Anindya., (2016) , Two subunits of human ORC are dispensable for DNA replication and proliferation , Elife, eLife Sciences Publications Limited,5,,e19084.
6 Kiran, Shashi., Anwar, Tarique., Kiran, Manjari., Ramakrishna, Gayatri., (2015) , Sirtuin 7 in cell proliferation, stress and disease: Rise of the Seventh Sirtuin! , Cellular signalling, Pergamon,27,3,673-682.
5 Bashyam, Murali D., Chaudhary, Ajay K., Kiran, Manjari., Nagarajaram, Hampapathalu A., Devi, Radha Rama., Ranganath, Prajnya., Dalal, Ashwin., Bashyam, Leena., Gupta, Neerja., Kabra, Madhulika., (2014) , Splice, insertion‐deletion and nonsense mutations that perturb the phenylalanine hydroxylase transcript cause phenylketonuria in India , Journal of cellular biochemistry, ,115,3,566-574.
4 Bashyam, Murali D., Chaudhary, Ajay K., Kiran, Manjari., Reddy, Venkat., Nagarajaram, Hampapathalu A., Dalal, Ashwin., Bashyam, Leena., Suri, Deepti., Gupta, Anju., Gupta, Neerja., (2014) , Molecular analyses of novel ASAH1 mutations causing Farber lipogranulomatosis: analyses of exonic splicing enhancer inactivating mutation , Clinical genetics, Blackwell Publishing Ltd Oxford, UK,86,6,530-538.
3 Manjari, Kiran., (2014) , Local and global hubs in human protein protein interaction network , , Manipal,,,.
2 Kiran, Manjari., Nagarajaram, Hampapathalu Adimurthy., (2013) , Global versus local hubs in human protein–protein interaction network , Journal of proteome research, American Chemical Society,12,12,5436-5446.
1 Bashyam, Murali D., Chaudhary, Ajay K., Sinha, Manjari., Nagarajaram, HA., Devi, A Radha Rama., Bashyam, Leena., Reddy, E Chandrakanth., Dalal, Ashwin., (2012) , Molecular genetic analysis of MSUD from India reveals mutations causing altered protein truncation affecting the C‐termini of E1α and E1β , Journal of cellular biochemistry, Wiley Subscription Services, Inc., A Wiley Company Hoboken,113,10,3122-3132.

Jan 2019-May 2019    Semester VIII: SB452 Computational systems biology : Network Biology (Theory + Practical = 2.5 credits)

                                    Semester IV: SB253 Evolution and Diversity (Theory = 1 credit)

July 2019-Nov 2019   Semester VII: SB403 Bioinformatics  (Theory + Practical = 5 Credits)

Jan 2020-May 2020    Semester VI: R programming (Practical = 2 credits)

                                    Semester VIII: Genomics: small RNA (2 credits)

My immediate interest lies in

  • Identification of Prognostic Signature in Cancers
  • Unraveling the role of Long non-coding RNAs in Cancers
  • Non-cancer drug repurposition
  • Postdoctoral fellow, Department of Biochemistry and Molecular Genetics, University of Virginia, USA

  • PhD in Computational Biology, CDFD, Manipal University, Hyderabad, India.

  • Masters in Bioinformatics, Banaras Hindu University (BHU), India

  • Bachelors in Zoology (Hons.), BHU, India
  • Travel Award, 2017: RNA Society of North Carolina to attend and present my work in the symposium on RNA Biology XII: RNA Tool and Target, University of North Carolina at Chapel Hill.

  • DoD Postdoctoral Training Award, 2016: 2 years Postdoctoral training award in prostate cancer from Department of Defense Congressionally Directed Medical Research Programs (DoD-CDMRP), U.S. Army Medical Research and Materiel Command (MCMR-CD). USA.

  • Travel Grant, 2013: Centre for DNA Fingerprinting and Diagnostics to attend and present my work in the ISMB/ECCB 2013, Berlin, Germany.

  • CSIR Research Fellowship, 2008: Council of Scientific and Industrial Research (CSIR), Govt. of India for pursuing research as a PhD student in India.