I am interested in applying computational approaches in understanding biology and human disease. I received my PhD training at CDFD Hyderabad during where I defined a novel dichotomy of hubs in human protein interaction networks. I also constructed a drug-target interaction network explaining the relation between side effects of drugs due to specific position of their targets in tissue specific interactions. During my post doctoral training, I used machine learning approaches for defining prognostic set of long non coding RNAs to predict outcome in glioma patients. Additionally, I used publicly available as well as in house generated RNA sequencing data to formulate hypothesis and validate findings for various biological problems.
In my current position at Hyderabad University, I intend to use my computational skills in addressing the role of long non-coding RNAs in cancers. I am also looking at the possibility of integrating interaction networks and NGS data to facilitate diagnosis and treatment regimens of cancer patients.
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|Mr. Shyam Venkatadri||MSc student project firstname.lastname@example.org||---|
|Ms. Anubha Dey||PhD email@example.com||---|
Former Students/Projects Trainees
|Jeevan Gochhayat||KVPY Summer Project Fellow||Centre for excellence in basic Sciences, DAE, Mumbai|
|17||Saha, Shekhar., Kiran, Manjari., Kuscu, Canan., Chatrath, Ajay., Wotton, David., Mayo, Marty W., Dutta, Anindya., (2020) , Long noncoding RNA DRAIC inhibits prostate cancer progression by interacting with IKK to inhibit NF-κB activation , Cancer Research, American Association for Cancer Research,,,.|
|16||Chatrath, Ajay., Przanowska, Roza., Kiran, Shashi., Su, Zhangli., Saha, Shekhar., Wilson, Briana., Tsunematsu, Takaaki., Ahn, Ji-Hye., Lee, Kyung Yong., Paulsen, Teressa., (2020) , The pan-cancer landscape of prognostic germline variants in 10,582 patients , Genome Medicine, BioMed Central,12,1,1-18.|
|15||Kiran, Manjari., Chatrath, Ajay., Tang, Xiwei., Keenan, Daniel Macrae., Dutta, Anindya., (2019) , A prognostic signature for lower grade gliomas based on expression of long non-coding RNAs , Molecular neurobiology, Springer US,56,7,4786-4798.|
|14||Chatrath, Ajay., Kiran, Manjari., Kumar, Pankaj., Ratan, Aakrosh., Dutta, Anindya., (2019) , The Germline Variants rs61757955 and rs34988193 Are Predictive of Survival in Lower Grade Glioma Patients , Molecular Cancer Research, American Association for Cancer Research,17,5,1075-1086.|
|13||Kiran, Manjari., (2018) , Role of a Novel Family of Short RNAs, tRFs, in Prostate Cancer , , VIRGINIA UNIV CHARLOTTESVILLE CHARLOTTESVILLE United States,,,.|
|12||Kuscu, Canan., Kumar, Pankaj., Kiran, Manjari., Su, Zhangli., Malik, Asrar., Dutta, Anindya., (2018) , tRNA fragments (tRFs) guide Ago to regulate gene expression post-transcriptionally in a Dicer-independent manner , Rna, Cold Spring Harbor Lab,24,8,1093-1105.|
|11||Reon, Brian J., Karia, Bruno Takao Real., Kiran, Manjari., Dutta, Anindya., (2018) , LINC00152 promotes invasion through a 3′-hairpin structure and associates with prognosis in glioblastoma , Molecular Cancer Research, American Association for Cancer Research,16,10,1470-1482.|
|10||Cichewicz, Magdalena A., Kiran, Manjari., Przanowska, Róża K., Sobierajska, Ewelina., Shibata, Yoshiyuki., Dutta, Anindya., (2018) , MUNC, an enhancer RNA upstream from the MYOD gene, induces a subgroup of myogenic transcripts in trans independently of MyoD , Molecular and Cellular Biology, American Society for Microbiology Journals,38,20,e00655-17.|
|9||Dutta, Anindya., Kumar, Pankaj., Kiran, Manjari., Kuscu, Canan., (2016) , Transfer RNA Fragments (tRFs): a Novel Class of Non-micro Short RNAs that Uses Ago1, 3 and 4 to Repress Specific Target RNAs Through 5′ Seed Sequences , The FASEB Journal, The Federation of American Societies for Experimental Biology,30,1_supplement,1054.5-1054.5.|
|8||Kiran, M., Nagarajaram, HA., (2016) , Interaction and localization diversities of global and local hubs in human protein–protein interaction networks , Molecular BioSystems, Royal Society of Chemistry,12,9,2875-2882.|
|7||Shibata, Etsuko., Kiran, Manjari., Shibata, Yoshiyuki., Singh, Samarendra., Kiran, Shashi., Dutta, Anindya., (2016) , Two subunits of human ORC are dispensable for DNA replication and proliferation , Elife, eLife Sciences Publications Limited,5,,e19084.|
|6||Kiran, Shashi., Anwar, Tarique., Kiran, Manjari., Ramakrishna, Gayatri., (2015) , Sirtuin 7 in cell proliferation, stress and disease: Rise of the Seventh Sirtuin! , Cellular signalling, Pergamon,27,3,673-682.|
|5||Bashyam, Murali D., Chaudhary, Ajay K., Kiran, Manjari., Nagarajaram, Hampapathalu A., Devi, Radha Rama., Ranganath, Prajnya., Dalal, Ashwin., Bashyam, Leena., Gupta, Neerja., Kabra, Madhulika., (2014) , Splice, insertion‐deletion and nonsense mutations that perturb the phenylalanine hydroxylase transcript cause phenylketonuria in India , Journal of cellular biochemistry, ,115,3,566-574.|
|4||Bashyam, Murali D., Chaudhary, Ajay K., Kiran, Manjari., Reddy, Venkat., Nagarajaram, Hampapathalu A., Dalal, Ashwin., Bashyam, Leena., Suri, Deepti., Gupta, Anju., Gupta, Neerja., (2014) , Molecular analyses of novel ASAH1 mutations causing Farber lipogranulomatosis: analyses of exonic splicing enhancer inactivating mutation , Clinical genetics, Blackwell Publishing Ltd Oxford, UK,86,6,530-538.|
|3||Manjari, Kiran., (2014) , Local and global hubs in human protein protein interaction network , , Manipal,,,.|
|2||Kiran, Manjari., Nagarajaram, Hampapathalu Adimurthy., (2013) , Global versus local hubs in human protein–protein interaction network , Journal of proteome research, American Chemical Society,12,12,5436-5446.|
|1||Bashyam, Murali D., Chaudhary, Ajay K., Sinha, Manjari., Nagarajaram, HA., Devi, A Radha Rama., Bashyam, Leena., Reddy, E Chandrakanth., Dalal, Ashwin., (2012) , Molecular genetic analysis of MSUD from India reveals mutations causing altered protein truncation affecting the C‐termini of E1α and E1β , Journal of cellular biochemistry, Wiley Subscription Services, Inc., A Wiley Company Hoboken,113,10,3122-3132.|
Jan 2019-May 2019 Semester VIII: SB452 Computational systems biology : Network Biology (Theory + Practical = 2.5 credits)
Semester IV: SB253 Evolution and Diversity (Theory = 1 credit)
July 2019-Nov 2019 Semester VII: SB403 Bioinformatics (Theory + Practical = 5 Credits)
Jan 2020-May 2020 Semester VI: R programming (Practical = 2 credits)
Semester VIII: Genomics: small RNA (2 credits)
My immediate interest lies in
- Identification of Prognostic Signature in Cancers
- Unraveling the role of Long non-coding RNAs in Cancers
- Non-cancer drug repurposition
- Postdoctoral fellow, Department of Biochemistry and Molecular Genetics, University of Virginia, USA
- PhD in Computational Biology, CDFD, Manipal University, Hyderabad, India.
- Masters in Bioinformatics, Banaras Hindu University (BHU), India
- Bachelors in Zoology (Hons.), BHU, India
- Travel Award, 2017: RNA Society of North Carolina to attend and present my work in the symposium on RNA Biology XII: RNA Tool and Target, University of North Carolina at Chapel Hill.
- DoD Postdoctoral Training Award, 2016: 2 years Postdoctoral training award in prostate cancer from Department of Defense Congressionally Directed Medical Research Programs (DoD-CDMRP), U.S. Army Medical Research and Materiel Command (MCMR-CD). USA.
- Travel Grant, 2013: Centre for DNA Fingerprinting and Diagnostics to attend and present my work in the ISMB/ECCB 2013, Berlin, Germany.
- CSIR Research Fellowship, 2008: Council of Scientific and Industrial Research (CSIR), Govt. of India for pursuing research as a PhD student in India.