Faculty Details

Faculty Details

  • Name: Dr. Manjari Kiran
  • Mail: manjari.hcuuohyd.ac.in
  • Contact: 04023134720
  • Area Of Research:Cancer Genomics; RNA Biology


Dr. Manjari Kiran is a computational biologist. She uses publicly available biological data to address fundamental questions in biology and generate data based models. She did her PhD with Prof. H. A. Nagarajaram at CDFD, Hyderabad. In her PhD, she proposed a novel dichotomy of highly connected proteins (Global and Local hubs) using human tissue-specific protein-protein interaction network.(Kiran and Nagarajaram, 2013, Journal of Proteome Res; Kiran and Nagarajaram, 2016, Mol Biosystems). 


After that she went on to work as research associate with Prof. Anindya DuttaUniversity of VirginiaThere she identified a set of 8 long non-coding RNAs (UVa-8) whose combined expression can predict survival in glioma patients (Kiran et al, 2018, Mol Neurobiology). Her work on prostate cancer specific tRNA-derived fragments as a prognostic marker and their role in prostate cancer metastasis was funded by Department of Defense (DoD) for two years of postdoctoral training. Apart from these, she has worked on several collaborative projects involving novel long non-coding RNAs (lncRNAs) in cancers (CYTOR and DRAIC) and muscle differentiation (MUNC) (Reon et al, 2018,Mol Can Res; Cichewicz et al, 2018, Mol Cel Bio; Saha et al, 2020, Cancer ResKuscu et al, 2018, RNA) and mapping of human origin of replication (Shibata et al, 2016, eLife).


In her current position at University of Hyderabad apart from teaching Bioinformatics, R programming and Network biology, she is interested in cancer genomics, non-coding RNAs, network based approaches in drug repurposition and machine learning to develop tools.


Awards

  • Travel Award, 2017: RNA Society of North Carolina to attend and present my work in the symposium on RNA Biology XII: RNA Tool and Target, University of North Carolina at Chapel Hill.
  • DoD Postdoctoral Training Award, 2016: 2 years Postdoctoral training award in prostate cancer from Department of Defense Congressionally Directed Medical Research Programs (DoD-CDMRP), U.S. Army Medical Research and Materiel Command (MCMR-CD). USA.
  • Travel Grant, 2013: Centre for DNA Fingerprinting and Diagnostics to attend and present my work in the ISMB/ECCB 2013, Berlin, Germany.
  • CSIR Research Fellowship, 2008: Council of Scientific and Industrial Research (CSIR), Govt. of India for pursuing research as a PhD student in India.

                                  

                                    

                                        

                                          

                                 


CV : Download CV

Title Details
Open Position

We are looking for highly motivated and interested candidate for PhD position. 

Students/Projects Trainees

Name Joined As Mail Contact
Ms. Anubha Dey PhD student 19lsph01@uohyd.ac.in ---
Mr. Lokhande Amardeep Bhagwan PhD student amardeeplokhande26@gmail.com ---
Mr. Haneesh Jindal SERB - Project JRF jindalhaneesh100@gmail.com ---
Ms. Gayathri R Master's Project Trainee gayathrir98@gmail.com ---
Mr. Shirshanya Roy PhD Student 21lsph06@uohyd.ac.in ---

Former Students/Projects Trainees

Name Joined As Working
Mr. Shyam Venkatadri MSc student project trainee Looking for job in Data Science and IT sector
Mr. Jeevan Gochhayat KVPY Summer Project Fellow Centre for excellence in basic Sciences, DAE, Mumbai
Mr. Sarthak Satpathy Master's Project Trainee PhD student at Emory University, Atlanta, Georgia
Ms. Surabhi Kavya Sri Master's Project Trainee Tata Consultancy Services, Hyderabad
24 Chandramohan, Nithya., Kiran, Manjari., Nagarajaram, Hampapathalu Adimurthy., (2021) , Comparative analysis of Pure Hubs and Pure Bottlenecks in Human Protein-protein Interaction Networks , bioRxiv, Cold Spring Harbor Laboratory,,,.
23 Namwanje, Maria., Bisunke, Bijay., Rousselle, Thomas V., Lamanilao, Gene G., Sunder, Venkatadri S., Patterson, Elizabeth C., Kuscu, Canan., Kuscu, Cem., Maluf, Daniel., Kiran, Manjari., (2021) , Rapamycin Alternatively Modifies Mitochondrial Dynamics in Dendritic Cells to Reduce Kidney Ischemic Reperfusion Injury , International journal of molecular sciences, Multidisciplinary Digital Publishing Institute,22,10,5386.
22 Kuscu, Canan., Kiran, Manjari., Mohammed, Akram., Kuscu, Cem., Satpathy, Sarthak., Wolen, Aaron., Bardhi, Elissa., Bajwa, Amandeep., Eason, James D., Maluf, Daniel., (2021) , Integrative Analyses of Circulating Small RNAs and Kidney Graft Transcriptome in Transplant Glomerulopathy , International Journal of Molecular Sciences, Multidisciplinary Digital Publishing Institute,22,12,6218.
21 Saha, Shekhar., Kiran, Manjari., Kuscu, Canan., Chatrath, Ajay., Wotton, David., Mayo, Marty W., Dutta, Anindya., (2020) , Long noncoding RNA DRAIC inhibits prostate cancer progression by interacting with IKK to inhibit NF-κB activation , Cancer research, American Association for Cancer Research,80,5,950-963.
20 Chatrath, Ajay., Przanowska, Roza., Kiran, Shashi., Su, Zhangli., Saha, Shekhar., Wilson, Briana., Tsunematsu, Takaaki., Ahn, Ji-Hye., Lee, Kyung Yong., Paulsen, Teressa., (2020) , The pan-cancer landscape of prognostic germline variants in 10,582 patients , Genome medicine, BioMed Central,12,1,1-18.
19 Kiran, Shashi., Kiran, Manjari., Ramakrishna, Gayatri., (2020) , Sirtuin 7 Promotes Mesenchymal to Epithelial Transition by β-Catenin Redistribution and Stabilization , Frontiers in oncology, Frontiers,10,,740.
18 Chakrabarti, Sankha S., Sunder, Venkatadri S., Kaur, Upinder., Bala, Sapna., Sharma, Priyanka., Kiran, Manjari., Rawal, Ravindra K., Chakrabarti, Sasanka., (2020) , Identifying the mechanisms of α-synuclein-mediated cytotoxicity in Parkinson’s disease: new insights from a bioinformatics-based approach , Future Neurology, Future Medicine Ltd London, UK,15,3,FNL49.
17 Kuscu, C., Kiran, M., Wolen, A., Kuscu, C., Bajwa, A., Eason, J., Maluf, D., Akalin, E., Mas, V., (2020) , Transcriptomic Profiling of Paired Serum and Biopsy Samples from FSGS Patients , AMERICAN JOURNAL OF TRANSPLANTATION, WILEY 111 RIVER ST, HOBOKEN 07030-5774, NJ USA,20,,643-643.
16 Lande, Kashmiri., Gupta, Jitesh., Ranjan, Ravi., Kiran, Manjari., Torres Solis, Luis Fernando., Solís Herrera, Arturo., Aliev, Gjumrakch., Karnati, Roy., (2020) , Exosomes: insights from retinoblastoma and other eye cancers , International Journal of Molecular Sciences, Multidisciplinary Digital Publishing Institute,21,19,7055.
15 Kiran, Manjari., Chatrath, Ajay., Tang, Xiwei., Keenan, Daniel Macrae., Dutta, Anindya., (2019) , A prognostic signature for lower grade gliomas based on expression of long non-coding RNAs , Molecular neurobiology, Springer US,56,7,4786-4798.
14 Chatrath, Ajay., Kiran, Manjari., Kumar, Pankaj., Ratan, Aakrosh., Dutta, Anindya., (2019) , The germline variants rs61757955 and rs34988193 are predictive of survival in lower grade glioma patients , Molecular Cancer Research, American Association for Cancer Research,17,5,1075-1086.
13 Kiran, Manjari., (2018) , Role of a Novel Family of Short RNAs, tRFs, in Prostate Cancer , , VIRGINIA UNIV CHARLOTTESVILLE CHARLOTTESVILLE United States,,,.
12 Kuscu, Canan., Kumar, Pankaj., Kiran, Manjari., Su, Zhangli., Malik, Asrar., Dutta, Anindya., (2018) , tRNA fragments (tRFs) guide Ago to regulate gene expression post-transcriptionally in a Dicer-independent manner , Rna, Cold Spring Harbor Lab,24,8,1093-1105.
11 Reon, Brian J., Karia, Bruno Takao Real., Kiran, Manjari., Dutta, Anindya., (2018) , LINC00152 promotes invasion through a 3′-hairpin structure and associates with prognosis in glioblastoma , Molecular Cancer Research, American Association for Cancer Research,16,10,1470-1482.
10 Cichewicz, Magdalena A., Kiran, Manjari., Przanowska, Róża K., Sobierajska, Ewelina., Shibata, Yoshiyuki., Dutta, Anindya., (2018) , MUNC, an enhancer RNA upstream from the MYOD gene, induces a subgroup of myogenic transcripts in trans independently of MyoD , Molecular and cellular biology, American Society for Microbiology 1752 N St., NW, Washington, DC,38,20,e00655-17.
9 Dutta, Anindya., Kumar, Pankaj., Kiran, Manjari., Kuscu, Canan., (2016) , Transfer RNA Fragments (tRFs): a Novel Class of Non‐micro Short RNAs that Uses Ago1, 3 and 4 to Repress Specific Target RNAs Through 5′ Seed Sequences , The FASEB Journal, The Federation of American Societies for Experimental Biology,30,,1054.5-1054.5.
8 Kiran, M., Nagarajaram, HA., (2016) , Interaction and localization diversities of global and local hubs in human protein–protein interaction networks , Molecular BioSystems, Royal Society of Chemistry,12,9,2875-2882.
7 Shibata, Etsuko., Kiran, Manjari., Shibata, Yoshiyuki., Singh, Samarendra., Kiran, Shashi., Dutta, Anindya., (2016) , Two subunits of human ORC are dispensable for DNA replication and proliferation , Elife, eLife Sciences Publications Limited,5,,e19084.
6 Kiran, Shashi., Anwar, Tarique., Kiran, Manjari., Ramakrishna, Gayatri., (2015) , Sirtuin 7 in cell proliferation, stress and disease: Rise of the Seventh Sirtuin! , Cellular signalling, Pergamon,27,3,673-682.
5 Bashyam, Murali D., Chaudhary, Ajay K., Kiran, Manjari., Nagarajaram, Hampapathalu A., Devi, Radha Rama., Ranganath, Prajnya., Dalal, Ashwin., Bashyam, Leena., Gupta, Neerja., Kabra, Madhulika., (2014) , Splice, insertion‐deletion and nonsense mutations that perturb the phenylalanine hydroxylase transcript cause phenylketonuria in India , Journal of cellular biochemistry, ,115,3,566-574.
4 Bashyam, Murali D., Chaudhary, Ajay K., Kiran, Manjari., Reddy, Venkat., Nagarajaram, Hampapathalu A., Dalal, Ashwin., Bashyam, Leena., Suri, Deepti., Gupta, Anju., Gupta, Neerja., (2014) , Molecular analyses of novel ASAH1 mutations causing Farber lipogranulomatosis: analyses of exonic splicing enhancer inactivating mutation , Clinical genetics, Blackwell Publishing Ltd Oxford, UK,86,6,530-538.
3 Kiran, Manjari., Nagarajaram, Hampapathalu Adimurthy., (2013) , Global versus local hubs in human protein–protein interaction network , Journal of proteome research, American Chemical Society,12,12,5436-5446.
2 Bashyam, Murali D., Chaudhary, Ajay K., Sinha, Manjari., Nagarajaram, HA., Devi, A Radha Rama., Bashyam, Leena., Reddy, E Chandrakanth., Dalal, Ashwin., (2012) , Molecular genetic analysis of MSUD from India reveals mutations causing altered protein truncation affecting the C‐termini of E1α and E1β , Journal of cellular biochemistry, Wiley Subscription Services, Inc., A Wiley Company Hoboken,113,10,3122-3132.
1 Manjari, Kiran., (1977) , Local and global hubs in human protein protein interaction network , , Manipal,,,.
Title Year Duration Amount(In Lakhs) PI/I
DBT-Centre for Microbial Informatics (DBT-CMI) (approved by the Taskforce, DBT; awaiting financial sanction) 2021 5 176 Prof. H.A.Nagarajaram (PI), Prof. Appa Rao Podile (Co-PI), Prof. Dayananda Siddavattam (Co-PI), Prof. Ch Venkataramana (Co-PI), Dr. Pankaj Singh (Co-PI), Dr. Vivek (Co-PI), Dr. Manjari Kiran (Co-PI)
A multi-omics and multi-label approach to predict genetic interactions in cancers 2021 3 25.84 Dr. Manjari Kiran
Identification of gender-specific prognostic genes in 27 human cancers. 2020 2 10 Dr. Manjari Kiran
A novel computational approach to generate genome based barcode intended to catalog Indian microbial species. 2020 5 68.6 Dr. Manjari Kiran, Dr. Pankaj S Dholaniya
Integrative approach to characterize human long non-coding RNAs. 2020 2 25.66 Dr. Manjari Kiran

Jan 2019-May 2019    Semester VIII: SB452 Computational systems biology : Network Biology (Theory + Practical = 2.5 credits)

                                    Semester IV: SB253 Evolution and Diversity (Theory = 1 credit)

July 2019-Nov 2019   Semester VII: SB403 Bioinformatics  (Theory + Practical = 5 Credits)

Jan 2020-May 2020    Semester VI: R programming (Practical = 2 credits)

                                    Semester VIII: Genomics: small RNA (2 credits)



1. Cancer Genomics
Genetic interactions in cancer 
Sex-biased prognostic genes in cancer

2. RNA Biology
Characterization of long and small non-coding RNAs 
RNA modifiers and epitranscriptomics

2022

12th May 2022 : Congratulation Manjari !!

Manjari has been selected for a six months SERB International Research Experience fellowship for 2022-2023. She will be visiting Dr. Douglas Phansteil's lab at the University of North Carolina for a short-term project involving the development of an R-package for Hi-C data analysis. 

8th Mar 2022: New addition to the lab

Welcome, Shirshanya !!

Shirshanya has joined the lab as a Ph.D. student. His area of interest is allelic imbalance in gene expression in cancer.

2021

14th Dec 2021: ISMB Membership

Manjari became a lifetime member of the International Society for Computational Biology

11th Nov 2021: Congratulation Anubha !!

Anubha got selected as JRF for UoH-IoE Research Grant. 

1st Oct 2021: UoH Institute of Eminence Research Grant 

Manjari got the UoH Institute of Eminence Research Grant for her proposal on a  multi-classifier based on multi-omics approach for predicting genetic interactions in cancer.

19th Aug 2021: New addition to the lab

Welcome, Amardeep !!


Amardeep has joined the lab as a Ph.D. student. His area of interest is RNA biology and genomics.

6th Aug 2021: New addition to the lab

Welcome, Gayathri !!


Gayathri has joined the lab as a master's thesis trainee and will work on a genome-wide comparison of m6A demethylase in humans and mice.

23 July 2021 : Congratulation, Sarthak and Surabhi, for the successful completion of project work!!

1 Jun 2021: MKLab has two Ph.D. vacancies. Interested candidates may apply at http://acad.uohyd.ac.in/ee21.html

9 May 2021 : Classes for the ongoing semester will resume after summer vacation 

The University of Hyderabad has announced a summer vacation for students and faculty from May 10 to June 08 because of the surge in COVID-19 cases. 

30 Mar 2021: Congratulation, Sarthak, for securing a Ph.D. position

Sarthak has been offered admission to the Computer Science and Informatics Program of the Laney Graduate School,  Emory University (GA, USA), starting in the fall semester of 2021.

5 Mar 2021: Anubha nominated for PMRF fellowship

The University of Hyderabad has nominated Anubha for a possible selection for fellowship under the Lateral Entry Channel of Prime Minister's Research Fellows (PMRF) scheme, December 2020 call.

23 Feb 2021: New addition to the lab

Welcome, Haneesh !!


Haneesh has joined the lab as SERB-Project JRF and will be working on computational approaches to characterize long non-coding RNAs.

Dr. Manjari Kiran is offering an Elective course on "R Programming" for the next semester starting on 8th March, 2021. Interested students may please contact their departmental office.

The lab is ready and functional now with the return of students. Welcome back !!

2020


16 Oct 2020: Poster Presentation in Biological Data Science Virtual Meeting, CSHL  (4-6 Nov 2020)

Sarthak's work on "Pan-cancer identification of sex-biased prognostic genes" has been selected for poster presentation in Cold Spring Harbor Laboratory "Biological Data Science Virtual Meeting."

5 Oct 2020: SERB Startup Research Grant

Manjari got SERB Startup Research Grant for her proposal on characterizing human long-non coding RNAs.

2 Sep 2020: New addition to the lab

Welcome, Sarthak and Surabhi !!