Dr. Nooruddin Khan, Ph.D.
Dr. Nooruddin Khan, Ph.D.
Department of Animal Biology,
School of Life Sciences,
University of Hyderabad,
Prof. C.R.Rao Road, Gachibowli, Hyderabad, 500046, India.
Mobile: +91 9866174764, Office: +91-040-2313 4590, Lab: +91-040-2313 4690
¨ 2003-2008: PhD (Molecular Immunology); Manipal University/Center for DNA fingerprinting and Diagnostics(CDFD)
¨ 2001-2003: MSc (Biotechnology); Jamia Hamdarad University,
¨ 1998-2001: BSc (Botony), Ramjas College, University of Delhi
¨ 2020- until now: Associate Professor, Department of Animal Biology, University of Hyderabad, Hyderabad.
¨ May 1, 2017-until now: Courtesy Assistant Professor at the Department of Microbiology and Immunology in the College of Veterinary Medicine; Cornell University, USA
¨ 2011-2020: Assistant Professor, Department of Biotechnology and Bioinformatics, University of Hyderabad, Hyderabad
¨ May-August, 2018: Visiting faculty at the Department of Biomedical Engineering, Cornell University, USA
¨ November-December, 2017: Visiting faculty at the Department of Microbiology and Immunology, Cornell University, USA
¨ 2008-2011: Post Doctoral Fellow; Emory Vaccine Center, Emory University with Prof Bali Pulendran
¨ 2019 University Chancellor's Award for excellence in teaching and research.
¨ 2016 USEFI Fulbright-Nehru Academic and Professional Excellence Flex Award.
¨ 2014 Shakuntla Amir Chand Prize for clinical research by ICMR (Indian council of Medical Research).
¨ 2014 DST-Fast-track.
¨ 2013 Chaturvedi Ghanshyam Das Jaigopal Memorial Award for outstanding research in Immunology by ICMR (Indian council of Medical Research).
¨ 2013 Bharat Jyoti Award, India International friendship society
¨ 2012 Bio Asia innovation award by Bio Asia Global Bio Business forum.
¨ 2007 Young Scientist Award by the Indian Immunological Society, India.
¨ 2005 INSA (Indian National Science Academy) Travel Grant.
¨ 2005 DST (Department of science and technology) Travel Grant.
¨ 2003 Noorul-Hasan Meritorious Award.
Membership in Academic/societies/professional bodies:
¨ Member of Indian Immunological Society, India.
¨ Member of Molecular Immunology Forum (MIF), India
|Shaikh Matin Rahim||PhD||---||---|
|Dr.Farhan Ahmed||Young Scientist||---||---|
|Kanaparthi Kala Jyothi||PhD||---||---|
|Rafiq Ahmad Khan||PhD||---||---|
|Aradhana Mariam Philips||Integrated MSc-PhD||---||---|
|Sai Nikhith Cholleti||PhD||---||---|
Former Students/Projects Trainees
|Dr. Srikanth Battu||PhD||Post Doctoral Fellow (La Jolla Institute of Immunology, USA)|
|Dr.Sumbul Afroz||PhD||Post Doctoral Fellow (Penn State University, USA)|
|Dr.Gillipsie Minhas||Post Doctoral Fellow||Novartis|
|Sai Sundeep||MSc||PhD (University of Nebraska Medical Center, USA)|
|Jeevan Giddaluru||Project Student||PhD (University of São Paulo, Brazil)|
|Koelina Ganguly||MSc||PhD (University of Nebraska Medical Center, USA)|
|Yashika Ratra||MSc||PhD (National Institute of Immunology, India)|
|Dhirendra Sharma||MSc||Scientist (Bhabha Atomic Research Center, India)|
|Rohith Kumar Guddeti||MSc||PhD (Indian Institute of Science Education and Research, Tirupati)|
|Shama||MSc||PhD (The Hong Kong Polytechnic University, Hong Kong, SAR China)|
|33||Philips AM, Khan Nooruddin (2021) , Amino acid sensing pathway: A major check point in the pathogenesis of obesity and COVID-19 , Obesity Review, ,22(4),,e13221.|
|32||Divya Gupta, Farhan Ahmed, Dixit Tandel, Haripriya Parthasarathy, DhiviyaVedagiri, Vishal Sah, Krishna Mohan Bodduluru, Siddarth Shreedas Daga, Rafiq Ahmad Khan, ......., *Nooruddin Khan, *Krishnan Harinivas Harshan. (2021) , Development of Equine Immunoglobulin Fragment F (ab') 2 with High Neutralizing Capability against SARS-CoV-2 , BioRxiv, ,,,.|
|31||Vivek Dhar Dwivedi,ShivBharadwaj,SumbulAfroz, Khan Nooruddin, Mairaj Ahmed Ansari, Umesh Yadava, Ramesh Chandra Tripathi, Indra Prasad Tripathi,Sarad Kumar Mishra (2020) , Anti-Dengue infectivity evaluation of bioflavonoid from Azadirachta indica by dengue virus serine protease inhibition , Journal of Biomolecular Structure and Dynamics , ,28,,1-16.|
|30||Panigrahi GC, Qureshi R, Jakkula P, Kumar KA, Khan Nooruddin, Qureshi IA (2020) , Leishmanial aspartyl-tRNA synthetase: Biochemical, biophysical and structural insights , International J Biol. Macromol. , ,15,2869-2885,165(Pt B).|
|29||Afroz S, Battu S, Giddaluru J, Khan Nooruddin (2020) , Dengue Virus Induced COX-2 Signaling Is Regulated Through Nutrient Sensor GCN2 , Frontier in Immunology, ,13,1831,11.|
|28||TejaswiniAppidi, Deepak Bharadwaj Pemmaraju, Rafiq Ahmad Khan, ..............,Khan Nooruddin *, Aravind Kumar Rengan*. (2020) , NIR light triggered selective ROS dependent autophagy for effective breast cancer therapy by CfAc/IR780 Nanoliposomes , Nanoscale , ,12,,2028.|
|27||Khan Nooruddin (2019) , Cellular stress response and immunological regulation during Mycobacterium tuberculosis: Molecular Infection Biology, Pathogen , Springer, Berlin Germany,,,.|
|26||Afroz S, Shama, Battu S, Matin S, Solouki S, Elmore JP, Minhas G, Huang W, August A, Khan Nooruddin (2019) , Amino acid starvation enhances vaccine efficacy by augmenting neutralizing antibody production , Science Signaling, ,12,607,12.|
|25||Khan RA, Afroz S, Minhas G, Battu S, Khan Nooruddin (2019) , Dengue virus envelope protein domain III induces pro-inflammatory signature and triggers activation of inflammasome , Cytokine, ,22,154780,123.|
|24||Alvi SB, Appidi T, Deepak BP, Rajalakshmi PS, Minhas G, Singh SP, Begum A, Bantal V, Srivastava R, Khan Nooruddin*Rengan AK* (2019) , The "nano to micro" transition of hydrophobic curcumin crystals leading to in situ adjuvant depots for Au-liposome nanoparticle mediated enhanced photothermal therapy , Biomaterial Science, ,163866-3875,,.|
|23||Saima Naz, Srikanth Battu, Rafiq Ahmad Khan, Sumbul Afroz,....Aleem Ahmed Khan, and Khan Nooruddin (2019) , Activation of integrated stress response pathway regulates IL-1 beta production in macrophages through post-transcriptional and translational reprogramming in mice , European J Immunology, ,49 ,277-289,2.|
|22||Bhat M.Y., Gul M.Z., Maurya R., Khan Nooruddin., Qureshi I.A., Ghazi I.A (2018) , Growth Inhibition and Apoptosis Inducing Effects of Artemisia absinthium L. Fractions on Chronic Myeloid Leukemia (K562) Cells , Journal of Biologically Active Products from Nature , ,8,70-89,2.|
|21||Naz S, Khan RA, Giddaluru J, Battu S, Vishwakarma SK, Subahan M, Satti V, Khan Nooruddin, Khan AA (2018) , Transcriptome meta-analysis identifies immune signature comprising of RNA binding proteins in ulcerative colitis patients , Cell Immunol., ,334,42-48,.|
|20||Srikanth Battu, Sumbul Afroz, Jeevan Giddaluru, Saima Naz,...Avery August, SeyedEhtesham Hasnain and Khan Nooruddin (2018) , Amino acid starvation sensing dampens IL-1beta production by activating riboclustering and autophagy , PLoS Biology, ,16,e2005317,4.|
|19||Battu S, Minhas G, Mishra A, Khan Nooruddin (2017) , Amino Acid Sensing via General Control Nonderepressible-2 Kinase and Immunological Programming , Frontiers in Immunology , ,11,1719,8.|
|18||Pemmaraju D, Appidi T, Minhas G, Singh SP, Khan Nooruddin, Pal M, Srivastava R, Rengan AK. (2017) , Chlorophyll rich biomolecular fraction of A. cadamba loaded into polymeric nanosystem coupled with Photothermal Therapy: A synergistic approach for cancer theranostics , Int J Biol. Macromol. , ,28,,.|
|17||Afroz S, Medhi H, Maity S, Minhas G, Battu S, Giddaluru J, Kumar K, *Paik P, *Khan Nooruddin (2017) , Mesoporous ZnO nanocapsules for the induction of enhanced antigen-specific immunological responses , Nanoscale, ,9,14641-14653,38.|
|16||Sumbul Afroz, Jeevan Giddaluru, Sandeep Vishwakarma, Saima Naz, Aleem Ahmed Khan and Khan Nooruddin (2017) , A comprehensive gene expression meta-analysis identifies novel immune signatures in Rheumatoid Arthritis patients , Frontiers in Immunology, ,2,74,8.|
|15||Bhat M.Y., Gul M.Z., Khan Nooruddin., Qureshi I.A., Ghazi I.A (2017) , Cytoprotective Activity and Anti-inflammatory Properties of Artemisia nilagirica (Clarke) Extracts-A Study with Macrophages , Journal of Biologically Active Products from Nature , ,228-244,,.|
|14||Minhas G, Sharma J, Khan Nooruddin (2016) , Cellular Stress Response and Immune Signaling in Retinal Ischemia-Reperfusion Injury , Frontiers in Immunology , ,7,,444.|
|13||Afroz S, Giddaluru J, Abbas MM, Khan Nooruddin (2016) , Transcriptome meta-analysis reveals a dysregulation in extra cellular matrix and cell junction associated gene signatures during Dengue virus infection , Scientific Report, ,6,,33752.|
|12||Khubaib M, Sheikh JA, Pandey S, Srikanth B, Bhuwan M, Khan Nooruddin, Hasnain SE, Ehtesham NZ (2016) , Mycobacterium tuberculosis Co-operonic PE32/PPE65 Proteins Alter Host Immune Responses by Hampering Th1 Response , Frontiers in Microbiology , ,7,,719.|
|11||Ganguly K, Giddaluru J, August A, Khan Nooruddin (2016) , Post-transcriptional Regulation of Immunological Responses through Riboclustering , Frontiers in Immunology , ,7,,161.|
|10||Ravindran R, Loebbermann J, Nakaya HI, Khan Nooruddin, Ma H,...,Martinez J, Pulendran B (2016) , The amino acid sensor GCN2 controls gut inflammation by inhibiting inflammasome activation , Nature, ,531,523-7,7595.|
|9||Tenguria S, Ansari SA, Khan Nooruddin, Ranjan A, Devi S, Tegtmeyer N, Lind J, Backert S, Ahmed N (2014) , Helicobacter pylori cell translocating kinase (CtkA/JHP0940) is pro-apoptotic in mouse macrophages and acts as auto-phosphorylating tyrosine kinase , International Journal of Medical Microbiology, ,304,1066-76,8.|
|8||Ravindran R, Khan Nooruddin, Nakaya HI, Li S, Loebbermann J, Maddur MS, Park Y, Jones DP, Chappert P, Davoust J, Weiss DS, Virgin HW, Ron D, Pulendran B (2014) , Vaccine activation of the nutrient sensor GCN2 in dendritic cells enhances antigen presentation , Science, ,343,313-7,6168.|
|7||Li S, Park Y, Duraisingham S, Strobel FH, Khan Nooruddin, Soltow QA, Jones DP, Pulendran B (2013) , Predicting network activity from high throughput metabolomics , PLoS Comput Biol. , ,9,e1003123,7.|
|6||Nakaya HI, Wrammert J, Lee EK, Racioppi L, Marie-Kunze S, Haining WN, Means AR, Kasturi SP, Khan Nooruddin, ....,Pulendran B (2011) , Systems biology of vaccination for seasonal influenza in humans , Nature Immunology, ,12,786-95,8.|
|5||Khan Nooruddin, Alam K, Mande SC, Valluri VL, Hasnain SE, Mukhopadhyay (2008) , S. Mycobacterium tuberculosis heat shock protein 60 modulates immune response to PPD by manipulating the surface expression of TLR2 on macrophages , Cell Microbiology, ,10,1711-22,8.|
|4||Khan Nooruddin, Alam K, Nair S, Valluri VL, Murthy KJ, Mukhopadhyay S (2008) , Association of strong immune responses to PPE protein Rv1168c with active tuberculosis , Clinical Vaccine Immunology , ,15,974-80,6.|
|3||Khan Nooruddin, Ghousunnissa S, Jegadeeswaran SM, Thiagarajan D, Hasnain SE, Mukhopadhyay S (2007) , Anti-B7-1/B7-2 antibody elicits innate-effector responses in macrophages through NF-kappa B-dependent pathway , International Immunology, ,19,477-86,4.|
|2||Khan Nooruddin, Rahim SS, Boddupalli CS, Ghousunnissa S, Padma S, Pathak N, Thiagarajan D, Hasnain SE, Mukhopadhyay S (2006) , Hydrogen peroxide inhibits IL-12 p40 induction in macrophages by inhibiting c-rel translocation to the nucleus through activation of calmodulin protein , Blood, ,107,1513-20,4.|
|1||Rahim SS, Khan Nooruddin, Boddupalli CS, Hasnain SE, Mukhopadhyay S (2005) , Interleukin-10 (IL-10) mediated suppression of IL-12 production in RAW 264.7 cells also involves c-rel transcription factor , Immunology, ,114,313-2,3.|
A Sponsored Research Projects:
¨ Role of integrated stress response (ISR) pathway in the regulation of immune responses during Dengue virus infection” under “Fast Track scheme for Young Scientists” (DST, India), ( Amount: Rs 27,00,000). [Duration (2014-2017)], Role-PI
¨ Programming protective humoral responses with novel vaccine formulations against Dengue Virus (DBT, Task force) ( Amount: Rs 64,15,000. [Duration (2014-2017)], Role-PI
¨ Nano-bead based approach to identify suitable vaccine candidate for latent Tuberculosis (DST, Nano-mission) Rs 49,40,690)-Role PI
¨ Structural and Functional Characterization of GCN5-relatedAcetyl-tranferases from M. tuberculosis. (3 lakhs, UPE-2 sponsored)-Co-PI.
¨ Functional characterization of the novel virulence mechanism encoded by the genomic plasticity zone of the human gastric pathogen H. pylori (under the Infection Biology Task Force DBT, 0.97 crore).
¨ Programming immunogenicity of latency-associated antigens of Mycobacterium Tuberculosis through Toll-Like receptors (TLRs)-UGC-MRP (14.5 lakhs)-Role-PI
¨ RNA binding protein mediated protein aggregation in the regulation of inflammation (UPE-II, 3.5 lakhs)-Role-Co-PI
¨ Functional-hollow-porous-biopolymer based Nanoformulations and Interventions for Treatment of Cancer and Prevention of Tuberculosis: concept of nanomedicine with multiple drugs for multiple diseases. (Rs 50.82 lakhs)-Role Co-PI.
¨ Poly Amino acid based Nanomedicine tbr Cotreatmcnt of Cancer and Tuberculosis (UPE-II, 3.5 lakhs)
¨ 12R-Lipoxygenase as a Target for Development of Drugs against Psoriasis; Drugs and Pharmaceuticals under Department of Science and Technology (F.No.VI-D&P/560/2016-17/TDT dated 30 December, 2016, (205 lakhs) Co-PI
Ongoing sponsored projects:
¨ Development of microbial Nano vesicle based multivalent Vaccine formulation against multiple poultry disease under DBT BIRAC (50 lakhs_-PI
¨ Nanovesicle based approach to develop tetravalent vaccine against Dengue Virus by ICMR (32.5 lakhs)-PI
¨ Inter and trans disciplinary project entitled "Development of new generation vaccine formulations against human and poultry pathogens and survey of its possible socio-economic implications in healthcare.” No.UOH/IOE: RC1-20-017 “ funded by IoE, University of Hyderabad, (Duration 3 years; Rs 229 lakhs) in collaboration with School of Chemistry, School of Enginnering and Department of Anthropology, University of Hyderabad. (Project Coordinator)
Ongoing Consultancy/Industry Projects:
Development of Inactivated COVID 19 virus as antigen for the production of therapeutic immunoglobulin fragment for treatment of COVID 19 infection” funded by VINS Bio-products Ltd , (Duration 1 years and extendable; Rs 13.8 lakhs) (Role-PI)
Technology Transfer :
Technology transfer for developing antibody fragment-based immunotherapy for immediate treatment of COVID-19 pandemic to Vins Bioproducts Ltd, a well-known anti-sera manufacturing company.
¨ A novel protein as potential candidate for development of anti-tuberculosis therapeutics. (US Patent Application No: 2010/0159, 485).
¨ A novel candidate protein to diagnose patients with active tuberculosis. (US Patent Application No: 2010/0129, 809).
¨ “Heterocyclic compounds as Lipoxygenase inhibitors" Provisional Indian Patent Application no. 201941024295; PCT Filing Date: May, 2020