Faculty Details

Faculty Details

  • Name: Dr. Roy Karnati
  • Mail: roykarnatigmail.com
  • Contact:
  • Area Of Research:Cellular homeostasis, Inflammation and Tumorigenesis
No Records Available

Students/Projects Trainees

Name Joined As Mail Contact
Mr. Jitesh Gupta Graduate Student --- ---
Mr. Ravi Ranjan Graduate Student --- ---
27 Karnati, Roy., Talla, Venu., Peterson, Katherine., Laurie, Gordon W., (2016) , Lacritin and other autophagy associated proteins in ocular surface health , Experimental eye research, Academic Press,144,,4-13.
26 Kumar, Naresh., Gupta, Geetika., Anilkumar, Kotha., Fatima, Naireen., Karnati, Roy., Reddy, Gorla Venkateswara., Giri, Priyanka Voori., Reddanna, Pallu., (2016) , 15-Lipoxygenase metabolites of α-linolenic acid,[13-(S)-HPOTrE and 13-(S)-HOTrE], mediate anti-inflammatory effects by inactivating NLRP3 inflammasome , Scientific reports, Nature Publishing Group,6,,31649.
25 Vantaku, Venkat Rao., Gupta, Geetika., Rapalli, Krishna Chaitanya., Karnati, Roy., (2015) , Lacritin Salvages human corneal epithelial cells from lipopolysaccharide induced cell death , Scientific reports, Nature Publishing Group,5,,18362.
24 Kumar, Naresh., Gangappa, D., Gupta, Geetika., Karnati, Roy., (2014) , Chebulagic acid from Terminalia chebula causes G1 arrest, inhibits NFκB and induces apoptosis in retinoblastoma cells , BMC complementary and alternative medicine, BioMed Central,14,1,319.
23 Yajarla, Varma NG., Nimmanapalli, Reddy P., Parikapandla, Sridevi., Gupta, Geetika., Karnati, Roy., (2014) , Anti-inflammatory and Anti-proliferative Properties of Chromolaena odorata Leaf Extracts in Normal and Skin-Cancer Cell Lines , Journal of herbs, spices & medicinal plants, Taylor & Francis,20,4,359-371.
22 Yadaiah, Madasu., Sudhamalla, Babu., Rao, P Nageswara., Roy, Karnati R., Ramakrishna, Dasari., Hussain Syed, Gulam., Ramaiah, Kolluru VA., Bhuyan, Abani K., (2013) , Arrested cell proliferation through cysteine protease activity of eukaryotic ribosomal protein S4 , The FASEB Journal, Federation of American Societies for Experimental Biology Bethesda, MD, USA,27,2,803-810.
21 Sudhamalla, Babu., Kumar, Mahesh., Roy, Karnati R., Kumar, R Sunil., Bhuyan, Abani K., (2013) , Cysteine endoprotease activity of human ribosomal protein S4 is entirely due to the C-terminal domain, and is consistent with Michaelis–Menten mechanism , Biochimica et Biophysica Acta (BBA)-General Subjects, Elsevier,1830,11,5342-5349.
20 Karnati, Roy., Laurie, Diane E., Laurie, Gordon W., (2013) , Lacritin and the tear proteome as natural replacement therapy for dry eye , Experimental eye research, Academic Press,117,,39-52.
19 Kashyap, Arun K., Reddy, Nimmanapalli P., Karnati, Roy., (2013) , Ethyl acetate extract of Hemigraphis colorata leaves shows anti-inflammatory and wound healing properties and inhibits 5-lipoxygenase and cyclooxygenase-1 and 2 enzymes , Journal of Medicinal Plants Research, Academic Journals,7,37,2783-2791.
18 Sinha, Sutapa., Roy, Sayantani., Reddy, Bathula Surendar., Pal, Krishnendu., Sudhakar, Godeshala., Iyer, Seethalakshmi., Dutta, Shamit., Wang, Enfeng., Vohra, Pawan Kumar., Roy, Karnati Rammohan., (2011) , A lipid-modified estrogen derivative that treats breast cancer independent of estrogen receptor expression through simultaneous induction of autophagy and apoptosis , Molecular cancer research, American Association for Cancer Research,9,3,364-374.
17 Roy, Karnati R., Reddy, Gorla V., Maitreyi, Leela., Agarwal, Smita., Achari, Chandrani., Vali, Shireen., Reddanna, Pallu., (2010) , Celecoxib inhibits MDR1 expression through COX-2-dependent mechanism in human hepatocellular carcinoma (HepG2) cell line , Cancer chemotherapy and pharmacology, Springer-Verlag,65,5,903-911.
16 Nishanth, Reddy P., Ramakrishna, BS., Jyotsna, Radhika G., Roy, Karnati R., Reddy, Gorla V., Reddy, Pratap K., Reddanna, Pallu., (2010) , C-Phycocyanin inhibits MDR1 through reactive oxygen species and cyclooxygenase-2 mediated pathways in human hepatocellular carcinoma cell line , European journal of pharmacology, Elsevier,649,1-3,74-83.
15 Agarwal, Smita., Achari, Chandrani., Praveen, D., Roy, Karnati R., Reddy, Gorla Venkateswara., Reddanna, Pallu., (2009) , Inhibition of 12‐LOX and COX‐2 reduces the proliferation of human epidermoid carcinoma cells (A431) by modulating the ERK and PI3K‐Akt signalling pathways , Experimental dermatology, Blackwell Publishing Ltd Oxford, UK,18,11,939-946.
14 Kumar, Kotha Anil., Arunasree, Kalle M., Roy, Karnati R., Reddy, Nishanth P., Aparna, Ankireddy., Reddy, Gorla Venkateswara., Reddanna, Pallu., (2009) , Effects of (15S)‐hydroperoxyeicosatetraenoic acid and (15S)‐hydroxyeicosatetraenoic acid on the acute‐lymphoblastic‐leukaemia cell line Jurkat: activation of the Fas‐mediated death pathway , Biotechnology and applied biochemistry, Blackwell Publishing Ltd Oxford, UK,52,2,121-133.
13 Kanwar, Shailender Singh., Roy, Karnati R., Nehru, Bimla., Reddanna, Pallu., Sanyal, Sankar Nath., (2009) , Na+-Stimulated Na+/H+ Exchange and an Unfavorable Ca2+ Homeostasis Initiate the Cycloxygenase-2 Inhibitors-Induced Apoptotic Signals in Colonic Epithelial Cells During the Early Stage of Colon Carcinogenesis , Oncology Research Featuring Preclinical and Clinical Cancer Therapeutics, Cognizant Communication Corporation,18,5-6,243-257.
12 McKown, Robert L., Wang, Ningning., Raab, Ronald W., Karnati, Roy., Zhang, Yinghui., Williams, Patricia B., Laurie, Gordon W., (2009) , Lacritin and other new proteins of the lacrimal functional unit , Experimental eye research, Academic Press,88,5,848-858.
11 Arunasree, Kalle M., Roy, Karnati R., Anilkumar, Kotha., Aparna, A., Reddy, Gorla Venkateswara., Reddanna, Pallu., (2008) , Imatinib-resistant K562 cells are more sensitive to celecoxib, a selective COX-2 inhibitor: role of COX-2 and MDR-1 , Leukemia research, Pergamon,32,6,855-864.
10 Aparna, Rachamallu., Subhashini, Jagu., Roy, Karnati R., Reddy, G Satyanarayana., Robinson, Matthew., Uskokovic, Milan R., Venkateswara Reddy, Gorla., Reddanna, Pallu., (2008) , Selective inhibition of cyclooxygenase‐2 (COX‐2) by 1α, 25‐dihydroxy‐16‐ene‐23‐yne‐vitamin D3, a less calcemic vitamin D analog , Journal of cellular biochemistry, Wiley Online Library,104,5,1832-1842.
9 Roy, Karnati R., Nishanth, Reddy P., Sreekanth, Devalraju., Reddy, Gorla Venkateswara., Reddanna, Pallu., (2008) , C‐Phycocyanin ameliorates 2‐acetylaminofluorene induced oxidative stress and MDR1 expression in the liver of albino mice , Hepatology Research, Blackwell Publishing Asia Melbourne, Australia,38,5,511-520.
8 Sreekanth, Devalraju., Arunasree, MK., Roy, Karnati R., Reddy, T Chandramohan., Reddy, Gorla V., Reddanna, Pallu., (2007) , Betanin a betacyanin pigment purified from fruits of Opuntia ficus-indica induces apoptosis in human chronic myeloid leukemia Cell line-K562 , Phytomedicine, Elsevier,14,11,739-746.
7 Roy, Karnati R., Arunasree, Kalle M., Reddy, Nishant P., Dheeraj, Bhavanasi., Reddy, Gorla Venkateswara., Reddanna, Pallu., (2007) , Alteration of mitochondrial membrane potential by Spirulina platensis C‐phycocyanin induces apoptosis in the doxorubicinresistant human hepatocellular‐carcinoma cell line HepG2 , Biotechnology and applied biochemistry, Blackwell Publishing Ltd Oxford, UK,47,3,159-167.
6 Mahipal, Suraneni VK., Subhashini, Jagu., Reddy, Madhava C., Reddy, Metukuri M., Anilkumar, Kotha., Roy, Karnati R., Reddy, Gorla V., Reddanna, Pallu., (2007) , Effect of 15-lipoxygenase metabolites, 15-(S)-HPETE and 15-(S)-HETE on chronic myelogenous leukemia cell line K-562: reactive oxygen species (ROS) mediate caspase-dependent apoptosis , Biochemical pharmacology, Elsevier,74,2,202-214.
5 Sathyasaikumar, KV., Swapna, I., Reddy, PVB., Murthy, Ch RK., Roy, KR., Gupta, A Dutta., Senthilkumaran, B., Reddanna, P., (2007) , Co-administration of C-Phycocyanin ameliorates thioacetamide-induced hepatic encephalopathy in Wistar rats , Journal of the neurological sciences, Elsevier,252,1,67-75.
4 Roy, Karnati R., Arunasree, Kalle M., Dhoot, Amit., Aparna, Rachamallu., Reddy, Gorla Venkateswara., Vali, Shireen., Reddanna, Pallu., (2007) , C-Phycocyanin inhibits 2-acetylaminofluorene-induced expression of MDR1 in mouse macrophage cells: ROS mediated pathway determined via combination of experimental and In silico analysis , Archives of biochemistry and biophysics, Elsevier,459,2,169-177.
3 Rao, P Nageswara., Yadaiah, Madasu., Roy, Karnati R., Potu, Harish., Bhuyan, Abani K., (2007) , Cloning, E. coli expression, refolding, and ATP-binding properties of a WD40-deleted Apaf-1 isoform , Protein expression and purification, Academic Press,56,2,220-228.
2 Reddy, Mallikarjuna M., Mahipal, Suraneni VK., Subhashini, Jagu., Reddy, Madhava C., Roy, Karnati R., Reddy, Gorla V., Reddy, Pingili RK., Reddanna, Pallu., (2006) , Bacterial lipopolysaccharide-induced oxidative stress in the impairment of steroidogenesis and spermatogenesis in rats , Reproductive Toxicology, Pergamon,22,3,493-500.
1 Reddy, GV., Babu, P Ravindra., Komaraiah, P., Roy, KRRM., Kothari, IL., (2003) , Utilization of banana waste for the production of lignolytic and cellulolytic enzymes by solid substrate fermentation using two Pleurotus species (P. ostreatus and P. sajor-caju) , Process Biochemistry, Elsevier,38,10,1457-1462.
Title Year Duration Amount(In Lakhs) PI/I
Development of 5-LOX specific scoring function and application of fragment based free energy methods for the development of novel anti-cancer drug candidates 2018 3 75 Roy Karnati
Elucidating the role of tyrosine phosphorylated proteins activated by lacritin in corneal epithelium 2018 2 10 Roy Karnati
Understand the regulation of lacritin expression during infection and characterize molecular pathways induced by lacritin in corneal epithelium 2018 2 35 Roy Karnati
Characterization of corneal cell death during infection; Regulation and cytoprotective role of lacritin, an eye specific protein 2012 3 30 Roy Karnati