| Epigenetic Regulation of Nuclear Geometry: Studies on the existence of Symmetric and Asymmetric Physical Gene Networks in the Mammalian Cell Nucleus |
1 year |
3 |
Sreenivasulu Kurukuti |
| Dynamics of interactions between chromosomes and nuclear envelop |
1 year |
3 |
CO-PI |
| Structural and functional studies of glucose 6-phosphate dehydrogenase and 6-phosphogluconate dehydrogenase to understand their role in leishmaniasis |
3 |
40.3 |
Insaf Ahmed Qureshi |
| Understanding the role of aminopeptidases in leishmaniasis through structural and functional studies |
3 |
20 |
Insaf Ahmed Qureshi |
| Elucidate the biochemical role of Protein-Protein interaction in the post-transcriptional regulations |
1 |
3.5 |
Insaf Ahmed Qureshi |
| Expression, purification and crystallographic studies of protein kinases from Plasmodium falciparum |
3 |
24.9 |
Insaf Ahmed Qureshi |
| Identification, purification and characterization of protein phosphatases PP1 from Leishmania donovani |
3 |
7.4 |
Insaf Ahmed Qureshi |
| Crystallographic study of casein kinase as structural-based target against malaria |
1 |
3 |
Insaf Ahmed Qureshi |
| Studies on epigenetic gene regulation during lactation and its impact on milk biosynthesis |
3 Years |
74.8 |
Sreenivasulu Kurukuti |
| Polymorphic dynamics of RNAPII transcriptional nanostructures in Biological system |
2 years |
10 |
Sreenivasulu Kurukuti |
| Development and application of high-resolution chromatin interaction method for characterization of long-range chromatin interactions in the Eukaryotic system |
3 Years |
25.9 |
Sreenivasulu Kurukuti |
| Spatial transcriptional dynamics of miRNA coding genes in the maintenance of regulated gene expression patterns during cellular development and differentiation |
3 Years |
90 |
Sreenivasulu Kurukuti |
| Computational prioritization and experimental validation of novel regulators required for maintenance of Hematopoietic stem cells. Total budget |
3 years |
25 |
Sreenivasulu Kurukuti |
| Epigenetic mechanisms in embryonic stem cell pluripotency and differentiation |
3 Years |
48 |
Sreenivasulu Kurukuti |
| Development and application of high-resolution genome conformation capture technology to investigate genome architecture in space and time |
2 Years |
91 |
Sreenivasulu Kurukuti |
| Chemical and genomic approaches to investigate possible link between development of antimicrobial resistance (AMR) and pharma industry effluents |
2 |
120 |
Prof. Dayananda Siddavatttam (PI), Prof. H.A.Nagarajaram (Co-PI), Prof. Ch Venkataramana (Co-PI) |
| Meiotic maturation of fish oocytes require steroidogenic shift: Interaction of hormone synthesizing enzyme and their transcriptional factors |
3 |
21.29 |
Prof. B Senthilkumaran |
| Localization of GnRHs in brain during gametogenesis, and impacts of monoamines blockers and sex steroids on GnRH release using Indian habitat fish species |
3 |
6.66 |
Prof. B Senthilkumaran |
| Molecular mechanisms of gonadal differentiation in fish tracing candidate marker genes to monitor germ cell proliferation and gametogenesis |
3 |
24.673 |
Prof. B Senthilkumaran |
| Molecular mechanisms of Estreogen induced brain and gonadal differentiation in Indian habitat fish species |
3 |
9 |
Prof. B Senthilkumaran |
| Identification of candidate genes/ susceptible to endocrine disruptors that affect reproduction: Functional genomics and proteomic approach |
3 |
37.48 |
Prof. B Senthilkumaran |
| Ontogeny of monoaminergic system in the male and female brain of catfish and its input to gonadal development |
3 |
19 |
Prof. B Senthilkumaran |
| Identification of transcription factors that play dual role to synchronize mesonephric and gonadal (urogenital) development in catfish |
3 |
46.03 |
Prof. B Senthilkumaran |
| Evaluating nanotoxicity using food fish models of India |
5 |
44.59 |
Prof. B Senthilkumaran |
| Sex manipulation in common carp and its hybrid using index major carp, rohu: genetic and molecular endocrinological approaches |
3 |
55.72 |
Prof. B Senthilkumaran |
| Unravelling the role of fibroblast growth factors and signaling during gametogenesis in teleosts |
3 |
19 |
Prof. B Senthilkumaran |
| Molecular characterization of genes/factors promoting testis growth and sperm maturation using teleosts fish models |
3 |
77.89 |
Prof. B Senthilkumaran |
| Genome wide screen for tomato mutants by TILLING- Phase-II |
5 |
270 |
Prof. R. P. Sharma |
| Program Support on Genome Engineering of Tomato |
5 |
417 |
Prof. R. P. Sharma |
| Non-transgenic crop improvement of grain amaranth (A. hypochandriacus) for determinate growth, enhanced seed yield and oil by establishment of TILLING by sequencing platform |
3 |
41 |
Prof. R. P. Sharma |
| Investigation on the mechanism of action of phytochrome in regulation of enzyme activity in higher plants |
3 |
0.8 |
Prof. R. P. Sharma |
| Dissection of signal chain involved in phytochrome regulation of beta-amylase activity in mustard cotyledons |
4 |
2.3 |
Prof. R. P. Sharma |
| Phytochrome regulation of membrane properties in higher plants |
3 |
7.07 |
Prof. R. P. Sharma |
| Studies on Photoregulation and role of beta-amylase enzyme in photomorphogenesis of mustard cotyledon |
3 |
1.7 |
Prof. R. P. Sharma |
| Isolation and characterization of phytochrome from green plant tissues |
3 |
5.4 |
Prof. R. P. Sharma |
| Third World Academy of Sciences |
1 |
0.15 |
Prof. R. P. Sharma |
| Regulation and role of leaf amylases in cereals |
4 |
1.5 |
Prof. R. P. Sharma |
| Alexander von Humboldt Foundation, Bonn, Germany |
1 |
1.8 |
Prof. R. P. Sharma |
| Analysis of photoperception and signal transmission in photomorphogenic mutants of higher plants |
4 |
26.5 |
Prof. R. P. Sharma |
| Developmental gradients and photoregulation of enzymes in monocot leaves |
4 |
7 |
Prof. R. P. Sharma |
| Volkswagen Foundation, Hanover, Germany. In Collaboration with University of Freiburg, Germany, Light-induced formation of components for protection against UV-B light in plants |
3 |
40 |
Prof. R. P. Sharma |
| Molecular-genetic characterization of the cotyledon morphogenesis using tomato mutants |
4 |
11 |
Prof. R. P. Sharma |
| Genetic and physical localization of the polycotyledon1 gene (poc) in tomato |
4 |
2.71 |
Prof. R. P. Sharma |
| International Atomic Energy Agency, Vienna, Austria project entitled “Isolation and |
5 |
19 |
Prof. R. P. Sharma |
| Molecular Analysis and Characterization of Phototropic Mutants of Tomato |
4 |
24 |
Prof. R. P. Sharma |
| Functional genomics of tomato: Induced mutations as tool for manipulating fruit ripening |
4 |
20 |
Prof. R. P. Sharma |
| Developmental regulation and functional analysis of PIN proteins in polycotyledon mutant of tomato |
3 |
4.77 |
Prof. R. P. Sharma |
| International Atomic Energy Agency, Vienna, Austria project entitled Evaluation of effect of gamma radiation on targeted DNA sequence in tomato mutants. |
7 |
19 |
Prof. R. P. Sharma |
| Molecular-genetic analysis of pattern formation in polycotyledon mutant of tomato |
4 |
1.8 |
Prof. R. P. Sharma |
| Genetic manipulation of tomato for improvement in shelf life of fruits |
5 |
55 |
Prof. R. P. Sharma |
| Genome wide screen for tomato mutants by TILLING |
5 |
365 |
Prof. R. P. Sharma |
| International Atomic Energy Agency, Vienna, Austria project entitled “Search for Hypermutable Lines of Tomato by TILLING and EcoTILLING” |
6 |
34 |
Prof. R. P. Sharma |
| Sequence-Indexed Library of Insertion Mutations in the Tomato Genome |
5 |
253 |
Prof. R. P. Sharma |
| Biofortification of tomato by targeted manipulation of the biosynthetic pathways |
8 |
1380 |
Prof. R. P. Sharma |
| Influence of phototropin genes on tomato fruit quality and shelf life |
5 |
151 |
Yellamaraju Sreelakshmi |
| Manipulation of light signaling components for improvement of tomato fruit quality |
5 |
144 |
Yellamaraju Sreelakshmi |
| Interaction between proteome and metabolome networks during tomato fruit ripening |
8 |
154 |
Yellamaraju Sreelakshmi |
| Comparative proteomics of tomato versus wild relatives during fruit colouration |
3 |
47.22 |
Yellamaraju Sreelakshmi |
| Mining for new alleles in tomato COP1 using EcoTILLING |
3 |
8.94 |
Yellamaraju Sreelakshmi |
| Reverse Genetic Selection of Mutants for Manipulation of Carotenoids Level in Tomato, International Atomic Energy Agency, Vienna, Austria |
6 |
3.35 |
Yellamaraju Sreelakshmi |
| Tomato fruit proteome analysis: a step towards understanding tomato genome |
4 |
35.24 |
Yellamaraju Sreelakshmi |
| Role of signalosome in plant development: Isolation of COP1 mutants in tomato by TILLING |
3 |
9.12 |
Yellamaraju Sreelakshmi |
| Membrane associated organophosphate (OPH) hydrolase complex in sphingobium fuliginis: determination of inter subunit interactions and elucidation of its role in acquisition of phosphate or iron. |
3 |
58.5 |
Dayananda Siddavattam |
| Comprehensive omics studies on a versatile Sphingomonad strain to establish theoretical basis for in situ bioremediation of recalcitrant environmental pollutants. |
2 |
57.9 |
Dayananda Siddavattam |
| Chemical and genomic approaches to investigate possible link between development of antimicrobial resistance (AMR) and pharma industry effluents. |
3 |
100 |
Dayananda Siddavattam |
| Role of non-coding small RNAs (sRNA) in regulation of carbon catabolic pathways In E. coli |
3 |
27.6 |
Dayananda Siddavattam |
| Discovery of gene missing components of regulatory network underlying C4 pathway/anatomy for translational research (Funding agency: DBT-ramalingaswami grant)) |
5 |
88 |
Vivek |
| Modulating the expression of topo2b to enhance the viability of CGNs through genome editing |
3 |
59.2 |
Dr. Pankaj Singh Dholaniya |
| 12R-Lipoxygenase as a Target for Development of Drugs against Psoriasis |
3 |
136 |
PI |
| Development of 12-LOX specific scoring function and Pharmacophore model: Design and biological evaluation of novel natural product derived inhibitors |
3 |
63 |
PI |
| Establishment of BioNEST incubation center |
5 |
500 |
PI |
| Basic Science Research Faculty Fellowship |
5 |
33 |
PI |
| Nucleolus in control of breast tumor heterogeneity |
3 |
94.97 |
Prof. Bramanandam Manavathi (PI); Prof. H.A.Nagarajaram (Co-PI) |
| Exploring the Volatome of NonCommunicable Diseases as a Promising Non-Invasive and Integrating Approach for its Rapid Diagnostics. The Case Study of Cancer and Neurodegenerative Diseases |
3 |
32.11 |
Prof. H.A. Nagarajaram (Co-PI) |
| Host-virus interactions-DBT |
3 |
52 |
Dr. M. Venkataramana/ Co PI- Dr. N. Prakash Prabhu, Department of Biotechnology and Bioinformatics |
| Elucidating the role of tyrosine phosphorylated proteins activated by lacritin in corneal epithelium |
2 |
10 |
Roy Karnati |
| Understand the regulation of lacritin expression during infection and characterize molecular pathways induced by lacritin in corneal epithelium |
2 |
35 |
Roy Karnati |
| Development of 5-LOX specific scoring function and application of fragment based free energy methods for the development of novel anti-cancer drug candidates |
3 |
75 |
Roy Karnati |
| Characterization of corneal cell death during infection; Regulation and cytoprotective role of lacritin, an eye specific protein |
3 |
30 |
Roy Karnati |
| Study of regulation of bacterial efflux pumps by cyclooxygenase-2 inhibitor, celecoxib. |
3 |
41 |
PI |
| Identification and characterization of posttranslational modifications of HDAC4 |
3 |
30 |
PI |
| celecoxib in combination with antibiotics on clinically isolated bacterial strains and in Mouse model of Sepsis |
3 |
61 |
PI |
| Study of regulation of ABC transporters by cyclooxygenase-2 (COX-2) and use of COX-2 inhibitors in reversal of drug resistance by ABC transporters |
3 |
23 |
PI |
| Exploration of antibacterial, immunomodulatory and anti-inflammatory activity of certain polyphenolic compounds and role of NSAIDs on activity of antibiotics |
3 |
23 |
PI |
| Molecular Dynamics Studies of the HDAC8 isoform, Virtual Screening of Potential HDAC8 Inhibitors using Structure and Ligand Based Studies – Synthesis and Biological Screening of Novel HDAC8 inhibitors |
3 |
21 |
PI |
| Role of Histone deacetylases (HDACs) in Maintenance of Inactive X chromosome (Xi) |
3 |
54.4 |
PI |
| Identification of candidate leptospiral antigens and host-specific biomarkers for the diagnosis and management of leptospirosis |
3 |
51 |
Prof. Manjula Sritharan |
| Understanding the role of HupB as an adhesion molecule:implications in extrapulmonary tuberculosis |
3 |
35 |
Prof. Manjula Sritharan |
| Epigenomic pathways orchestrating cell development and function |
1 |
3.5 |
Prof. Manjula Sritharan |
| Interaction of the iron-regulated protein HupB of Mycobacterium tuberculosis with Fe3 - high affinity siderophores and synthesis of mycobactin T and analogues |
2 |
4.4 |
Prof. Manjula Sritharan |
| Development of multiplex PCR and Real Time PCR assay systems for the identification of Methicillin Resistant Staphylococcus aureus (MRSA) |
3 |
25 |
Prof. Manjula Sritharan |
| Sero-diagnosis of leptospirosis: development and validation of immunoassays for the detection of anti-leptospiral antibodies in serum samples |
3 |
31.7 |
Prof. Manjula Sritharan |
| Virtual Centre of Excellence on multi-disciplinary approaches aimed at interventions against Mycobacterium tuberculosis |
5 |
44.7 |
Prof. Manjula Sritharan |
| DNA microarray analysis for the identification of molecular markers in Mycobacterium tuberculosis expressed during iron limitation and latency Multi-departmental project of UoH |
4 |
15 |
Prof. Manjula Sritharan |
| Anti-tubercular compounds targeting the iron-acquisition machinery of M. tuberculosis (Joint project with Prof. SubhashPadhye (SP), Univ.of Pune) |
4 |
31.9 |
Prof. Manjula Sritharan |
| Virulence factors of Leptospira |
4 |
28.82 |
Prof. Manjula Sritharan |
| HbpA, a novel hemin-binding protein as a serodiagnostic agent for leptospirosis |
1 |
4.98 |
Prof. Manjula Sritharan |
| Studies on plasma iron levels in patients with tuberculosis and in vivo expression of iron-regulated proteins in Mycobacterium tuberculosis |
3 |
10.6 |
Prof. Manjula Sritharan |
| Biochemical evaluation of iron deprivation in Mycobacterium tuberculosis with specific reference to iron-regulated envelope proteins and to action of anti-mycobacterial drugs |
3 |
14.67 |
Prof. Manjula Sritharan |
| Iron, catalase and INH activation in M. tuberculosis |
3 |
11.96 |
Prof. Manjula Sritharan |
| Diagnostic potential of the culture filtrate antigens of M. tuberculosis |
1 |
2.7 |
Prof. Manjula Sritharan |
| Iron deprivation in pathogenic Leptospira spp.: identification and characterization of iron-regulated membrane proteins |
2 |
22 |
Prof. Manjula Sritharan |
| Iron deprivation in pathogenic Leptospira spp.: identification and characterization of iron-regulated membrane proteins |
3 |
8.28 |
Prof. Manjula Sritharan |
| Antibodies against the iron-regulated envelope proteins in M. bovis BCG |
2 |
0.2 |
Prof. Manjula Sritharan |
| Diagnosis and development of vaccines against cattle diseases caused by Mycobacterium bovis and leptospires |
3 |
64.93 |
Prof. Manjula Sritharan |
| Host-virus interactions - SERB |
3 |
55 |
Dr. M. Venkataramana/ Co PI - Dr. Kota Arun Kumar, Department of Animal Biology |
| Host-virus interactions - MHRD-IISC STARS |
3 |
99 |
Dr. M. Venkataramana/ Co PI- Prof. Naresh Babu V. Sepuri, Department of Biochemistry |
| Hypoxia Alters Calcium Influx in the Glomerular Podocytes: Implications in Cytoskeletal Derangement and Proteinuria |
3 |
60 |
P Anil Kumar |
| Assessment of antimicrobial and plant growth promoting potential of indigenous endophytic bacterial strains of Manipur” under DBT’s Twinning Programme for NER (No. BT/PR25395/NER/95/1177/2017) |
3 years |
15.3 |
Prof. Sharmistha Banerjee |
| Identification and Characterization of mycobacterial factors supporting HIV propagation during HIV-mycobacteria co-infection (BT/HRD/NWBA/38/09/2018) |
5 years |
25 |
Prof. Sharmistha Banerjee |
| Design and Development of novel antitubercular agents targeting Shikimate kinase protein” under DBT (No. BT/PR23619/MED/29/1199/2017, dated 09.01.2018) |
3 years |
21.6 |
Prof. Sharmistha Banerjee |
| Centre of Excellence in Biomolecular structure and function on Host-Pathogen interaction (BT/PR15450/COE/34/46/2016) |
5 years |
76.11 |
Prof. Sharmistha Banerjee |
| Environmental stress responses in protein structure and metabolism of plant and algal chloroplasts |
3 |
173 |
S Rajagopal |
| Genetic manipulation of ripening-associated ERFs for the regulation of ripening in tomato |
5 |
35 |
PI |
| Investigations on the carotenoids level in tomato genotypes with altered ethylene signalling |
1 |
3.5 |
PI |
| Creation of a genetic resource of ........fruit ripening and phosphate starvation response |
3 |
20 |
PI |
| Engineering of ................ traits in tomato |
3 |
40.83 |
PI |
| Understanding genetic diversity ..... to low phosphate in tomato |
3 |
35 |
PI |
| Exploring the natural .. for phosphate starvation responses |
2 |
11.82 |
PI |
| Redox constraints regulate photorespiration |
3.5 |
93.82 |
Prof. A. S. Raghavendra |
| Engineering Photosynthesis in Mulberry for Resilience to Climate Change: A C4 Approach |
4 |
23.37 |
Prof. A. S. Raghavendra |
| Modulation of Photorespiration by Oxidative Stress: Role of Oxygen and Reactive Nitrogen Species |
3 |
36.48 |
Prof. A. S. Raghavendra |
| Identification of novel alleles of wild rice derived bacterial blight resistance genes and their functional analysis |
3 Years |
29.59 |
PI |
| Transcriptome dynamics during drought stress in foxtail millet |
5 |
35 |
M Muthamilarasan |
| Reducing antinutritional traits in millets using next-gen genomics approaches |
3 |
33 |
M Muthamilarasan |
| Role of Topoisomerase VI in the biology of malaria parasite |
3 |
72.28 |
Sunanda Bhattacharyya (PI) |
| Role of Hsp90 in Rad51 mediated DNA repair |
3 |
15.5 |
Sunanda Bhattacharyya (PI) |
| Structure function relationship of Hsp90 in yeast telomere |
3 |
40 |
Sunanda Bhattacharyya (PI) |
| Cloning and characterization of Plasmodium falciparum Topoisomerase VI |
3 |
30 |
Sunanda Bhattacharyya (PI) |
| Understanding the role of homologous recombination in genomic rearrangements leading to antigenic diversification in malaria parasites |
3 |
49.3 |
Sunanda Bhattacharyya (Co-PI) |
| To study the role of Hsp90 in DNA double strand break repair pathway |
1 |
3 |
Sunanda Bhattacharyya (PI) |
| Role of proteins and protein aggregates in cellular physiology and disease progression |
1 |
3 |
Sunanda Bhattacharyya (Co-PI) |
| Long non-coding RNA Regulation: Role in megakaryocyte development |
3 |
18 |
PI |
| From small to big: microRNAs as new players in developmental megakaryocytopoiesis |
3 |
46.6 |
PI |
| Toll-like Receptor Signalling: Significance in Megakaryocyte Development and Platelet Production |
3 |
46.2 |
PI |
| SETDB1 in hematopoiesis and hematopoietic tumors: Target genes and their regulation |
3 |
30 |
Mentor |
| Molecular regulation of the differences between neonatal and adult megakaryocytopoiesis leading to bleeding disorders |
3 |
25 |
PI |
| Potential signaling pathways in molecular regulation of different developmental stages of human megakaryocytes |
3 |
52.9 |
PI |
| Identification and characterization of novel microRNA of clinical importance from neonatal and adult derived megakaryocytes |
3 |
9.6 |
PI |
| miR-9/Runx1 mediates developmental regulation of distinct megakaryocytopoiesis |
3 |
33.25 |
PI |
| Role of Toll-like Receptor Signaling Mediated Disease Resistance in Indian Poultry |
3 |
27.25 |
PI |
| Potential role of miR-9 regulation in CXCR-4 expression at different developmental stages of human megakaryocytes |
4 |
41.81 |
PI |
| Centre of Excellence in Biomolecular Structure and Function on Host Pathogen Interactions |
5 |
69.8 |
Krishnaveni Mishra |
| Role of SUMOylation in virulence of Candida glabrata |
3 |
48.028 |
Krishnaveni Mishra |
| Identification of the SUMOylation target in yeast heterochromatin |
3 |
20 |
Krishnaveni Mishra |
| Enzyme cascade biocatalysis in the stereoselective synthesis of chiral intermediates |
3 |
20 |
Santosh Kumar Padhi |
| Quantitative proteomics of Protein Body components (lectins and glycosidases), from the Trichosanthes anguina seeds: elucidation of protein-protein interactions in the protein body biogenesis |
2 Years |
10 |
Prof. N. Siva Kumar |
| Biochemical investigation of endosomal targeting proteins and functional analysis of lysosomal enzymes and their receptors in Hydra |
3 Years |
58 |
Prof. N. Siva Kumar |
| Growth hormone mediates glomerular podocyte hypertrophy: Implications in diabetic nephropathy |
3 |
18 |
P. Anil Kumar |
| Hypoxia-mediated epithelial-mesenchymal transition |
3 |
38 |
P. Anil Kumar |
| Prevention of epithelial-mesenchymal transition of podocytes by inhibition of natural antisense transcript for ZEB2: Implications for prevention of diabetic nephropathy |
3 |
51 |
P. Anil Kumar |
| Novel Non-Canonical Role of Growth hormone on Glomerular Podocytes |
5 |
68 |
P. Anil Kumar |
| Role of Growth hormone on Mammary Epithelial Carcinoma |
3 |
18 |
P. Anil Kumar |
| Growth hormone induces IL-17 in glomerular podocytes: Implications in the pathogenesis of diabetic nephropathy |
3 |
30 |
P. Anil Kumar |
| Silica-induced Nephrotoxicity: Implications in Uddanam Kidney Disease of Unknown Origin |
3 |
50 |
P. Anil Kumar |
| The role of WT1 in Obesity-related glomerulonephropathy |
3 |
80 |
P. Anil Kumar |
| Identification of gender-specific prognostic genes in 27 human cancers. |
2 |
7.94 |
Dr. Manjari Kiran |
| A novel computational approach to generate genome based barcode intended to catalog Indian microbial species. |
5 |
68.6 |
Dr. Manjari Kiran, Dr. Pankaj S Dholaniya |
| 1. Regulatory functions of microRNAs during early lymphoid lineage differentiation |
3 |
57 |
Jagan Pongubala |
| 2. Cis-regulatory configuration controlling B-lineage gene expression |
3 |
70 |
Jagan Pongubala |
