Faculty Details

Faculty Details

  • Name: Prof. Manjula Sritharan
  • Mail: mssluohyd.ernet.in
  • Contact: 9866304464
  • Area Of Research:Infection Biology: Tuberculosis and Leptospirosis


Academic qualifications and Experience

·         M.Sc Biochemistry, Faculty of Medicine (JIPMER, Pondicherry)

·         Ph.D. from University of Hull, UK

·         Postdoctoral fellow at Harvard School of Tropical Public Health, Boston, USA

·         Reader, Anna University at the Centre for Biotechnology (1992-97)

·         Reader and Professor, University of Hyderabad (2000 - till date)

Administrative Experience: University of Hyderabad

·         Chairman of MoU committee (2018-ongoing)

·         Professor-in-charge, Office of the Post Doctoral Affairs (2015 - 2018)

·         Deputy Coordinator, UGC-SAP-CAS (2009 - 2014)

·         Head, Department of Animal Sciences, School of Life Sciences (2010 - 2012)

·         Management Committee of Study in India Program (2009 - ongoing)

·         Advisory Committee, UPE-2 program of University of Hyderabad (2014 – 2017)

·         PhD Course work Coordinator (2009 – 2014)

Awards & Honours

·         Commonwealth Faculty Fellow, United Kingdom

·         Commonwealth Split-Site Fellowship for two doctoral candidates

·         Fellow of the Telangana Academy of Sciences

·         Nehru-Fulbright Doctoral & Professional Research Fellowship for doctoral candidate

·         Fellow of Association of Biomedical Scientists (FABMS)

·         K. P. Sinha & P. S. Krishnan award for best paper from Association of Clinical Biochemists of India

Member of National Level Committees

·         Working Group for revising Recombinant DNA safety guidelines,  DBT, New Delhi (2015)

·         Member of the Advisory Committee of SAP(DRSII) of Department of Biotechnology, Assam University, Silchar (2018-2023)

·         Member of the Advisory Committee of SAP(DRSII) of Department of Biochemistry, University of Madras (2016 – 2021)

·         Member of the Review Committee Final Review of UGC-SAP program in Department of Zoology, University of Bangalore (2016)

Member of External Committees

·         Member of Institutional Biosafety Committee, Indian Immunologicals Pvt. Ltd (2011 – ongoing)

·         DBT Nominee of IBSC Committee, National Institute of Animal Biotechnology (2013 – 2016)

·         Member of Institutional Ethical Committee, CCMB, Hyderabad (2010 – 2021)

·         Member of the Biosafety Committee, RCC Labs, Shameerpet, Hyderabad (2015 – 2018)

·         Member of Institutional Biosafety Committee, NIN, Hyderabad (2016 – 2019)

·         Member of Board of Studies in Biotechnology, University of Madras (2016 – 2018)

Member of Professional bodies

·         Member of the American Society of Microbiology (ASM), USA

·         Member of the International Leptospirosis Society

·         Life member, Society of Biological Chemists (SBC), India

·         Life Member of the Indian Association of Medical Microbiologists (IAMM)

·         Life Member of the Association of Bio-Medical Scientists of India

·         Life Member of the Indian Leptospirosis Society (ILS)

Academic and Research Achievements

·         Teaching: Core Courses - Molecular Biology, Genetic Engineering and Biochemistry; Elective courses - Infection Biology and Vaccinology.

·         Research: Tuberculosis and Leptospirosis

o   Understanding host-pathogen interactions with specific interest in iron acquisition by pathogenic Mycobacterium tuberculosis and pathogenic Leptospira spp.

o   First global report on the direct iron acquisition machinery by the hemin-binding protein HbpA by Leptospira interrogans serovar Lai

o   Sphingomyelinases as virulence factors in pathogenic Leptospira

o   Identification of HupB (Rv2986c) as an IdeR-dependent iron-regulated protein in M. tuberculosis

o   Characterisation of HupB as a transcriptional activator of mycobactin biosynthesis

o   Iron transporter role of HupB

o   Methylation of HupB of M. tuberculosis by host methylase

o   Diagnostic potential of HbpA and sphingomyelinase in the screening of leptospirosis

o   Clinical significance of HupB in extrapulmonary tuberculosis

o   Screening of chemically synthesized compounds for anti-tubercular activity

 

 

No Records Available
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49 Hari Parapatla, Ramurthy Gudla, Guruprasad Varma Konduru, Elsin Raju Devadasu,. Hampapathula Adimurthy Nagarajaram, Manjula Sritharan, Rajagopal Subramanyam and Dayananda Siddavattam (2020) , Organophosphate hydrolase interacts with ferric-enterobactin and promotes iron uptake in association with TonB dependent transport system , Biochemical Journal, ,477,,2821-2840IF - 4.331.
48 Yaseen, Imtiyaz., Choudhury, Mitali., Sritharan, Manjula., Khosla, Sanjeev., (2018) , Histone methyltransferase SUV39H1 participates in host defense by methylating mycobacterial histone‐like protein HupB , The EMBO journal, John Wiley & Sons, Ltd,37,2,183-200.
47 Chaurasia, R., Thresiamma, KC., Eapen, CK., Zachariah, BJ., Paul, R., Sritharan, M., (2018) , Pathogen-specific leptospiral proteins in urine of patients with febrile illness aids in differential diagnosis of leptospirosis from dengue , European Journal of Clinical Microbiology & Infectious Diseases, Springer Berlin Heidelberg,37,3,423-433.
46 Thresiamma, KC., Bijou, A., Chaurasia, Reetika., Sritharan, Manjula., Jayaprakash, Chithra., Thomas, Sunil., Eapen, CK., (2017) , Proteinuria in early detection of human leptospirosis , Int J Res Med Sci, ,5,2,646-652.
45 Sritharan, Manjula., (2016) , Iron homeostasis in Mycobacterium tuberculosis: mechanistic insights into siderophore-mediated iron uptake , Journal of bacteriology, American Society for Microbiology Journals,198,18,2399-2409.
44 Sritharan, N., Choudhury, M., Sivakolundu, S., Chaurasia, R., Chouhan, N., Rao, PP., Sritharan, M., (2015) , Highly immunoreactive antibodies against the rHup-F2 fragment (aa 63–161) of the iron-regulated HupB protein of Mycobacterium tuberculosis and its potential for the serodiagnosis of extrapulmonary and recurrent tuberculosis , European Journal of Clinical Microbiology & Infectious Diseases, Springer Berlin Heidelberg,34,1,33-40.
43 Sarguna, P., Rao, M Raja., Sivakolundu, S., Chaurasia, R., Sritharan, M., Shankar, K., (2015) , Urban leptospirosis: A report of two cases , Indian journal of medical microbiology, Medknow Publications,33,2,321.
42 Narayanavari, Suneel A., Lourdault, Kristel., Sritharan, Manjula., Haake, David A., Matsunaga, James., (2015) , Role of sph2 gene regulation in hemolytic and sphingomyelinase activities produced by Leptospira interrogans , PLoS neglected tropical diseases, Public Library of Science,9,8,.
41 Pandey, Satya Deo., Choudhury, Mitali., Yousuf, Suhail., Wheeler, Paul R., Gordon, Stephen V., Ranjan, Akash., Sritharan, Manjula., (2014) , Iron-regulated protein HupB of Mycobacterium tuberculosis positively regulates siderophore biosynthesis and is essential for growth in macrophages , Journal of bacteriology, American Society for Microbiology Journals,196,10,1853-1865.
40 Dandawate, Prasad., Vemuri, Kiranmayi., Khan, Ejazuddin M., Sritharan, Manjula., Padhye, Subhash., (2014) , Synthesis, characterization and anti-tubercular activity of ferrocenyl hydrazones and their β-cyclodextrin conjugates , Carbohydrate polymers, Elsevier,108,,135-144.
39 Pandey, Satya Deo., Choudhury, Mitali., Sritharan, Manjula., (2014) , Transcriptional regulation of Mycobacterium tuberculosis hupB gene expression , Microbiology, Microbiology Society,160,8,1637-1647.
38 Dandawate, Prasad., Vemuri, Kiranmayi., Swamy, K Venkateswara., Khan, Ejazuddin M., Sritharan, Manjula., Padhye, Subhash., (2014) , Synthesis, characterization, molecular docking and anti-tubercular activity of Plumbagin–Isoniazid Analog and its β-cyclodextrin conjugate , Bioorganic & medicinal chemistry letters, Pergamon,24,21,5070-5075.
37 Sivakolundu, Subha., Mannela, Uma Devi., Jain, Suman., Srikantam, Aparna., Peri, Sundaresh., Pandey, Satya Deo., Sritharan, Manjula., (2013) , Serum iron profile and ELISA-based detection of antibodies against the iron-regulated protein HupB of Mycobacterium tuberculosis in TB patients and household contacts in Hyderabad (Andhra Pradesh), India , Transactions of the Royal Society of Tropical Medicine and Hygiene, Oxford University Press,107,1,43-50.
36 Yadlapalli, Rama Krishna., Chourasia, OP., Vemuri, Kiranmayi., Sritharan, Manjula., Perali, Ramu Sridhar., (2012) , Synthesis and in vitro anticancer and antitubercular activity of diarylpyrazole ligated dihydropyrimidines possessing lipophilic carbamoyl group , Bioorganic & medicinal chemistry letters, Elsevier,22,8,2708-2711.
35 Narayanavari, Suneel A., Sritharan, Manjula., Haake, David A., Matsunaga, James., (2012) , Multiple leptospiral sphingomyelinases (or are there?) , Microbiology, Microbiology Society,158,Pt 5,1137.
34 Narayanavari, Suneel A., Kishore, Nanda M., Sritharan, M., (2012) , Structural analysis of the leptospiral sphingomyelinases: in silico and experimental evaluation of Sph2 as an Mg++-dependent sphingomyelinase , Journal of molecular microbiology and biotechnology, Karger Publishers,22,1,24-34.
33 Sivakolundu, Subha., Sivakumar, Rathinam R., Chidambaranathan, Gowri Priya., Sritharan, Manjula., (2012) , Serological diagnosis of leptospiral uveitis by HbpA IgG ELISA , Journal of medical microbiology, Microbiology Society,61,12,1681-1687.
32 Duggirala, S., Venu, K., Subhakar, K., Sritharan, M., (2012) , T-cell recognition of iron-regulated culture filtrate proteins of Mycobacterium tuberculosis in tuberculosis patients and endemic normal controls , Indian journal of medical microbiology, Medknow Publications,30,3,323.
31 Jamadar, Abeda., Duhme-Klair, Anne-K., Vemuri, Kiranmayi., Sritharan, Manjula., Dandawate, Prasad., Padhye, Subhash., (2012) , Synthesis, characterisation and antitubercular activities of a series of pyruvate-containing aroylhydrazones and their Cu-complexes , Dalton Transactions, Royal Society of Chemistry,41,30,9192-9201.
30 Narayanavari, Suneel A., Sritharan, Manjula., Haake, David A., Matsunaga, James., (2012) , Multiple leptospiral sphingomyelinases (or are there?)(vol 158, pg 1137, 2012) , MICROBIOLOGY-SGM, SOC GENERAL MICROBIOLOGY MARLBOROUGH HOUSE, BASINGSTOKE RD, SPENCERS WOODS …,158,,1931-1932.
29 Manjula Sritharan (2012) , Leptospirosis: a neglected disease , Zoonosis, InTech Publishers,,,.
28 Sivakolundu, Subha., Nagendrakumar, SB., Suneel, NA., (2011) , OJVRTM , Online Journal of Veterinary Research, ,15,6,476-484.
27 Chavadi, Sivagamisundaram., Wooff, Esen., Coldham, Nicholas G., Sritharan, Manjula., Hewinson, R Glyn., Gordon, Stephen V., Wheeler, Paul R., (2009) , Global effects of inactivation of the pyruvate kinase gene in the Mycobacterium tuberculosis complex , Journal of bacteriology, American Society for Microbiology Journals,191,24,7545-7553.
26 Velineni, Sridhar., Ramadevi, Sanam., Asuthkar, Swapna., Sritharan, Manjula., (2009) , Effect of iron deprivation on expression of sphingomyelinase in pathogenic serovar Lai , Online J Bioinform, ,10,2,241-58.
25 Velineni, Sridhar., Ramadevi, Sanam., Asuthkar, Swapna., Sritharan, Manjula., (2009) , Iron-regulated expression of sphingomyelinase and identification of a putative transporter TolC in Leptospira interrogans serovar Lai , Online Journal of Bioinformatics, ,10,2,241-258.
24 Sridhar, Velineni., Devi, Sundru Manjulata., Ahmed, Niyaz., Sritharan, Manjula., (2008) , Diagnostic potential of an iron-regulated hemin-binding protein HbpA that is widely conserved in Leptospira interrogans , Infection, Genetics and Evolution, Elsevier,8,6,772-776.
23 Asuthkar, Swapna., Velineni, Sridhar., Stadlmann, Johannes., Altmann, Friedrich., Sritharan, Manjula., (2007) , Expression and characterization of an iron-regulated hemin-binding protein, HbpA, from Leptospira interrogans serovar Lai , Infection and immunity, American Society for Microbiology Journals,75,9,4582-4591.
22 Velineni, S., Asuthkar, S., Umabala, P., Lakshmi, V., Sritharan, M., (2007) , Serological evaluation of leptospirosis in Hyderabad, Andhra Pradesh: A retrospective hospital-based study , Indian journal of medical microbiology, Medknow Publications,25,1,24.
21 Sritharan, M., (2006) , Iron and bacterial virulence , Indian journal of medical microbiology, Medknow,24,3,163.
20 Yeruva, Veena C., Duggirala, Sridevi., Lakshmi, V., Kolarich, Daniel., Altmann, Friedrich., Sritharan, Manjula., (2006) , Identification and characterization of a major cell wall-associated iron-regulated envelope protein (Irep-28) in Mycobacterium tuberculosis , Clin. Vaccine Immunol., American Society for Microbiology,13,10,1137-1142.
19 Sritharan, Manjula., Yeruva, Veena C., Sivasailappan, Sivagamisundaram C., Duggirala, Sridevi., (2006) , Iron enhances the susceptibility of pathogenic mycobacteria to isoniazid, an antitubercular drug , World Journal of Microbiology and Biotechnology, Kluwer Academic Publishers,22,12,1357.
18 Sritharan, M., Asuthkar, S., Sridhar, V., (2006) , Understanding iron acquisition by pathogenic leptospires: a review , Indian journal of medical microbiology, Medknow Publications,24,4,311.
17 Velineni, S., Asuthkar, S., Sritharan, M., (2006) , Iron limitation and expression of immunoreactive outer membrane proteins in Leptospira interrogans serovar icterohaemorrhagiae strain lai , Indian journal of medical microbiology, Medknow Publications,24,4,339.
16 Sritharan, M., Ramadevi, S., Pasupala, N., Tajne, S., Asuthkar, S., (2005) , In silico identification and modelling of a putative iron-regulated TonB-dependant outer membrane receptor protein from the genome of Leptospira interrogans serovar Lai , Online Journal of Bioinformatics, ,6,,74-90.
15 Sritharan, M., Sritharan, V., (2004) , Emerging problems in the management of infectious diseases: the biofilms , Indian journal of medical microbiology, Medknow Publications,22,3,140.
14 Sritharan, M., Asuthkar, S., (2004) , Iron-regulated proteins (IRPS) of leptospira biflexa serovar Patoc strain Patoc I , Indian journal of medical microbiology, Medknow Publications,22,2,92.
13 Sritharan, Manjula., (2000) , Iron as a candidate in virulence and pathogenesis in mycobacteria and other microorganisms , World Journal of Microbiology and Biotechnology, Kluwer Academic Publishers,16,8-9,769-780.
12 Sritharan, Manjula., Sritharan, Venkataraman., (2000) , Polymerase chain reaction in the diagnosis of tuberculosis , Indian Journal of Clinical Biochemistry, Springer India,15,1,200-216.
11 Kamatchiammal, Senthilkumar., Saravanakumar, Dhashinamoorthy., Kumarasamy, Nagalingeswaran., Solomon, Sunithi., Sritharan, Manjula., Sritharan, Venkataraman., (2000) , Direct diagnosis ofMycobacterium tuberculosis in blood samples of HIV infected patients by polymerase chain reaction , Indian Journal of Clinical Biochemistry, Springer India,15,2,76-82.
10 Saravanakumar, D., Elangeswaran, N., Senthilkumar, S., Vanaja, G., Kamakshiammal, S., Chandrasekar, C., Deivanayagam, CN., Sritharan, Manjula., Sritharan, V., (2000) , Isolation, PCR based identification, and sensitivity pattern of environmental mycobacteria from leprosy and tuberculosis patients , Indian Journal of Clinical Biochemistry, Springer,15,2,94-103.
9 Rao, Vivek K., Sritharan, Manjula., (1999) , Identification of a LDL-receptor in the lymphatic filarial parasiteWuchereria bancrofti , Indian Journal of Clinical Biochemistry, Springer India,14,2,213-219.
8 Sritharan, Manjula., Piessens, WF., (1997) , Actin of Brugia malayi microfilariae contains a developmentally regulated antigenic epitope. , Molecular and biochemical parasitology, ,90,1,327.
7 Kamatchiammal, Senthilkumar., Saravanakumar, Dhashinamoorthy., Kumarasamy, Nagalingeswaran., Solomon, Sunithi., Sritharan, Manjula., Sritharan, Venkataraman., (1997) , A simple method for inhibition free PCR amplification of target DNA directly from clinical specimens , Indian Journal of Clinical Biochemistry, Springer,12,1,78.
6 Kunthala Jayaraman, Manjula Sritharan (1996) , Gene Technology , Concepts in Biotechnology, University Press, Orient Longman Ltd,,,.
5 Sritharan, Manjula., Ratledge, Colin., (1990) , Iron-regulated envelope proteins of mycobacteria grown in vitro and their occurrence inMycobacterium avium andMycobacterium leprae grown in vivo , Biology of metals, Springer-Verlag,2,4,203-208.
4 Manjula Sritharan (1990) , Studies on the tissue distribution of liposome associated Clofazimine, an antileprosy drug , Experimental and Clinical Pharmacologymacol, ,15,,107-111.
3 Sritharan, Manjula., Ratledge, Colin., (1989) , Co-ordinated expression of the components of iron transport (mycobactin, exochelin and envelope proteins) in Mycobacterium neoaurum , FEMS microbiology letters, Blackwell Publishing Ltd Oxford, UK,60,2,183-185.
2 HALL, RICHARD M., SRITHARAN, MANJULA., MESSENGER, ANN JM., RATLEDGE, COLIN., (1987) , Iron transport in Mycobacterium smegmatis: occurrence of iron-regulated envelope proteins as potential receptors for iron uptake , Microbiology, Microbiology Society,133,8,2107-2114.
1 Sritharan V, Sritharan M, Sharma AK, Murthy PS (1986) , Studies on the membranes of Mycobacterium vaccae. Chemical and antigenic analysis , Proc. Indo-UK symposium on leprosy, ,,,163-173.
Title Year Duration Amount(In Lakhs) PI/I
Understanding the role of HupB as an adhesion molecule:implications in extrapulmonary tuberculosis 2017 3 35 Prof. Manjula Sritharan
Identification of candidate leptospiral antigens and host-specific biomarkers for the diagnosis and management of leptospirosis 2017 3 51 Prof. Manjula Sritharan
Epigenomic pathways orchestrating cell development and function 2016 1 3.5 Prof. Manjula Sritharan
Development of multiplex PCR and Real Time PCR assay systems for the identification of Methicillin Resistant Staphylococcus aureus (MRSA) 2015 3 25 Prof. Manjula Sritharan
Interaction of the iron-regulated protein HupB of Mycobacterium tuberculosis with Fe3 - high affinity siderophores and synthesis of mycobactin T and analogues 2014 2 4.4 Prof. Manjula Sritharan
Sero-diagnosis of leptospirosis: development and validation of immunoassays for the detection of anti-leptospiral antibodies in serum samples 2012 3 31.7 Prof. Manjula Sritharan
Virtual Centre of Excellence on multi-disciplinary approaches aimed at interventions against Mycobacterium tuberculosis 2008 5 44.7 Prof. Manjula Sritharan
DNA microarray analysis for the identification of molecular markers in Mycobacterium tuberculosis expressed during iron limitation and latency Multi-departmental project of UoH 2008 4 15 Prof. Manjula Sritharan
Anti-tubercular compounds targeting the iron-acquisition machinery of M. tuberculosis (Joint project with Prof. SubhashPadhye (SP), Univ.of Pune) 2008 4 31.9 Prof. Manjula Sritharan
Virulence factors of Leptospira 2008 4 28.82 Prof. Manjula Sritharan
HbpA, a novel hemin-binding protein as a serodiagnostic agent for leptospirosis 2008 1 4.98 Prof. Manjula Sritharan
Studies on plasma iron levels in patients with tuberculosis and in vivo expression of iron-regulated proteins in Mycobacterium tuberculosis 2007 3 10.6 Prof. Manjula Sritharan
Biochemical evaluation of iron deprivation in Mycobacterium tuberculosis with specific reference to iron-regulated envelope proteins and to action of anti-mycobacterial drugs 2007 3 14.67 Prof. Manjula Sritharan
Iron, catalase and INH activation in M. tuberculosis 2007 3 11.96 Prof. Manjula Sritharan
Diagnostic potential of the culture filtrate antigens of M. tuberculosis 2005 1 2.7 Prof. Manjula Sritharan
Iron deprivation in pathogenic Leptospira spp.: identification and characterization of iron-regulated membrane proteins 2003 2 22 Prof. Manjula Sritharan
Iron deprivation in pathogenic Leptospira spp.: identification and characterization of iron-regulated membrane proteins 2002 3 8.28 Prof. Manjula Sritharan
Antibodies against the iron-regulated envelope proteins in M. bovis BCG 2000 2 0.2 Prof. Manjula Sritharan
Diagnosis and development of vaccines against cattle diseases caused by Mycobacterium bovis and leptospires 2000 3 64.93 Prof. Manjula Sritharan